LRRC25 - leucine rich repeat containing 25 Gene

Homo sapiens

Also known as MAPA

Gene ID: 126364 | Gene type: protein coding

About LRRC25

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:18,391,137-18,397,622 (from NCBI)

This gene has 2 transcripts (splice variants) and 82 orthologues. Broad expression in spleen (RPKM 16.6), bone marrow (RPKM 11.9) and 16 other tissues.

Summary

Predicted to be located in cytoplasm. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

LRRC25 Products(1)

mRNA	Protein	Name
NM_145256.3	NP_660299.2	leucine-rich repeat-containing protein 25 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRRC25 Protein Structure

LRR_4

0
100
200
305 a.a.

Protein Preferred Names

Protein Names

leucine-rich repeat-containing protein 25

monocyte and plasmacytoid activated molecule

LRRC25 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LRRC25	Q8N386	CLEC1A	Homo sapiens	Q8NC01	Validated Y2H	32296183
Intra	LRRC25	Q8N386	CNIH3	Homo sapiens	Q8TBE1	Validated Y2H	32296183
Intra	LRRC25	Q8N386	CLDN19	Homo sapiens	Q8N6F1-2	Validated Y2H	32296183
Intra	LRRC25	Q8N386	PKMYT1	Homo sapiens	Q99640-2	Validated Y2H	32296183
Intra	LRRC25	Q8N386	GPRC5D	Homo sapiens	Q9NZD1	Validated Y2H	32296183
Intra	LRRC25	Q8N386	AGPAT4	Homo sapiens	Q9NRZ5	Validated Y2H	32296183
Intra	LRRC25	Q8N386	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	LRRC25	Q8N386	FAM3C	Homo sapiens	Q92520	Validated Y2H	32296183
Intra	LRRC25	Q8N386	CLN6	Homo sapiens	Q9NWW5	Validated Y2H	32296183
Intra	LRRC25	Q8N386	ACD	Homo sapiens	Q96AP0	Pull Down	21044950
Intra	LRRC25	Q8N386	ACD	Homo sapiens	Q96AP0	BiFC	21044950
Intra	LRRC25	Q8N386	TMEM120A	Homo sapiens	Q9BXJ8	Validated Y2H	32296183
Intra	LRRC25	Q8N386	FATE1	Homo sapiens	Q969F0	Validated Y2H	32296183
Intra	LRRC25	Q8N386	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183
Intra	LRRC25	Q8N386	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183
Intra	LRRC25	Q8N386	YIPF6	Homo sapiens	Q96EC8	Validated Y2H	32296183
Intra	LRRC25	Q8N386	TRAF3IP3	Homo sapiens	Q9Y228	Validated Y2H	32296183
Intra	LRRC25	Q8N386	DNAJC30	Homo sapiens	Q96LL9	Validated Y2H	32296183
Intra	LRRC25	Q8N386	SMCO4	Homo sapiens	Q9NRQ5	Validated Y2H	32296183
Intra	LRRC25	Q8N386	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LRRC25 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70876	LRRC25 Protein, Human (HEK293, His)	Q8N386 (L21-T165)	≥95%

Related Diseases

Diseases

Alias

Campylobacteriosis

Campylobacter Infections	Campylobacter Infection
Enteric Campylobacteriosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07812	LRRC25 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LRRC25	VGNC	VGNC:74401
Bos taurus	LRRC25	VGNC	VGNC:31006
Canis familiaris	LRRC25	VGNC	VGNC:42791
Rattus norvegicus	LRRC25	RGD	RGD:1564818
Felis catus	LRRC25	VGNC	VGNC:63292
Mus musculus	LRRC25	MGD	MGI:2445284
Others	LRRC25	NCBI

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