CNIH3 - cornichon family AMPA receptor auxiliary protein 3 Gene

Homo sapiens

Also known as CNIH-3

Gene ID: 149111 | Gene type: protein coding

About CNIH3

This gene has 14 transcripts (splice variants), 194 orthologues and 4 paralogues. Biased expression in brain (RPKM 4.8), testis (RPKM 1.6) and 10 other tissues.

Summary

Predicted to enable channel regulator activity. Involved in regulation of AMPA Receptor activity. Predicted to be located in dendritic shaft and postsynaptic membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in dendrite and glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2022]

CNIH3 Products(5)

mRNA	Protein	Name
NM_001322302.2	NP_001309231.1	protein cornichon homolog 3 isoform 2
NM_001322303.2	NP_001309232.1	protein cornichon homolog 3 isoform 3
NM_001322304.2	NP_001309233.1	protein cornichon homolog 3 isoform 4
NM_001322305.2	NP_001309234.1	protein cornichon homolog 3 isoform 5
NM_152495.2	NP_689708.1	protein cornichon homolog 3 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of AMPA receptor activity	IDA IDA: Inferred from direct assay	20805473	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNIH3 Protein Structure

Cornichon

0
100
160 a.a.

Protein Preferred Names

Protein Names

protein cornichon homolog 3

cornichon homolog 3

CNIH3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CNIH3	Q8TBE1	SORT1	Homo sapiens	Q99523	Validated Y2H	32296183
Intra	CNIH3	Q8TBE1	SORT1	Homo sapiens	Q99523	Y2H Array	32296183
Intra	CNIH3	Q8TBE1	SORT1	Homo sapiens	Q99523	Y2H Prey Pooling	32296183
Intra	CNIH3	Q8TBE1	NEMP1	Homo sapiens	O14524-2	Y2H Array	32296183
Intra	CNIH3	Q8TBE1	NEMP1	Homo sapiens	O14524-2	Y2H Prey Pooling	32296183
Intra	CNIH3	Q8TBE1	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	CNIH3	Q8TBE1	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	CNIH3	Q8TBE1	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	CNIH3	Q8TBE1	LRRC25	Homo sapiens	Q8N386	Y2H Array	32296183
Intra	CNIH3	Q8TBE1	LRRC25	Homo sapiens	Q8N386	Y2H Prey Pooling	32296183
Intra	CNIH3	Q8TBE1	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	CNIH3	Q8TBE1	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	CNIH3	Q8TBE1	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	CNIH3	Q8TBE1	TMEM80	Homo sapiens	Q96HE8	Y2H Prey Pooling	32296183
Intra	CNIH3	Q8TBE1	TMEM80	Homo sapiens	Q96HE8	Validated Y2H	32296183
Intra	CNIH3	Q8TBE1	TMEM80	Homo sapiens	Q96HE8	Y2H Array	32296183
Intra	CNIH3	Q8TBE1	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	CNIH3	Q8TBE1	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	CNIH3	Q8TBE1	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	CNIH3	Q8TBE1	FNDC9	Homo sapiens	Q8TBE3	Validated Y2H	32296183
Intra	CNIH3	Q8TBE1	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	CNIH3	Q8TBE1	TMPRSS2	Homo sapiens	O15393-2	Y2H Array	32296183
Intra	CNIH3	Q8TBE1	TMPRSS2	Homo sapiens	O15393-2	Y2H Prey Pooling	32296183
Intra	CNIH3	Q8TBE1	ODF4	Homo sapiens	Q2M2E3	Y2H Array	32296183
Intra	CNIH3	Q8TBE1	ODF4	Homo sapiens	Q2M2E3	Y2H Prey Pooling	32296183
Intra	CNIH3	Q8TBE1	CEACAM3	Homo sapiens	P40198	Y2H Prey Pooling	32296183
Intra	CNIH3	Q8TBE1	CEACAM3	Homo sapiens	P40198	Y2H Array	32296183
Intra	CNIH3	Q8TBE1	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	CNIH3	Q8TBE1	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	CNIH3	Q8TBE1	LEUTX	Homo sapiens	A8MZ59	Y2H Prey Pooling	32296183
Intra	CNIH3	Q8TBE1	LEUTX	Homo sapiens	A8MZ59	Y2H Array	32296183
Intra	CNIH3	Q8TBE1	TMEM52B	Homo sapiens	Q4KMG9	Y2H Prey Pooling	32296183
Intra	CNIH3	Q8TBE1	TMEM52B	Homo sapiens	Q4KMG9	Y2H Array	32296183
Intra	CNIH3	Q8TBE1	SUSD3	Homo sapiens	Q96L08	Validated Y2H	32296183
Intra	CNIH3	Q8TBE1	SUSD3	Homo sapiens	Q96L08	Y2H Array	32296183
Intra	CNIH3	Q8TBE1	SUSD3	Homo sapiens	Q96L08	Y2H Prey Pooling	32296183
Intra	CNIH3	Q8TBE1	FAM210B	Homo sapiens	Q96KR6	Y2H Prey Pooling	32296183
Intra	CNIH3	Q8TBE1	FAM210B	Homo sapiens	Q96KR6	Validated Y2H	32296183
Intra	CNIH3	Q8TBE1	FAM210B	Homo sapiens	Q96KR6	Y2H Array	32296183
Intra	CNIH3	Q8TBE1	CLDN20	Homo sapiens	P56880	Y2H Prey Pooling	32296183
Intra	CNIH3	Q8TBE1	CLDN20	Homo sapiens	P56880	Y2H Array	32296183
Intra	CNIH3	Q8TBE1	PLD3	Homo sapiens	Q8IV08	Y2H Prey Pooling	32296183
Intra	CNIH3	Q8TBE1	PLD3	Homo sapiens	Q8IV08	Y2H Array	32296183
Intra	CNIH3	Q8TBE1	KCNN4	Homo sapiens	O15554	Y2H Prey Pooling	32296183
Intra	CNIH3	Q8TBE1	KCNN4	Homo sapiens	O15554	Y2H Array	32296183
Intra	CNIH3	Q8TBE1	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	CNIH3	Q8TBE1	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	CNIH3	Q8TBE1	SMIM3	Homo sapiens	Q9BZL3	Y2H Prey Pooling	32296183
Intra	CNIH3	Q8TBE1	SMIM3	Homo sapiens	Q9BZL3	Validated Y2H	32296183
Intra	CNIH3	Q8TBE1	SMIM3	Homo sapiens	Q9BZL3	Y2H Array	32296183
Intra	CNIH3	Q8TBE1	VSIR	Homo sapiens	Q9H7M9	Y2H Prey Pooling	32296183
Intra	CNIH3	Q8TBE1	VSIR	Homo sapiens	Q9H7M9	Validated Y2H	32296183
Intra	CNIH3	Q8TBE1	VSIR	Homo sapiens	Q9H7M9	Y2H Array	32296183
Intra	CNIH3	Q8TBE1	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	CNIH3	Q8TBE1	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	CNIH3	Q8TBE1	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	CNIH3	Q8TBE1	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	CNIH3	Q8TBE1	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	CNIH3	Q8TBE1	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	CNIH3	Q8TBE1	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	CNIH3	Q8TBE1	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	CNIH3	Q8TBE1	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	CNIH3	Q8TBE1	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	CNIH3	Q8TBE1	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Splenic Artery Aneurysm

Aneurysm Of Splenic Artery

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02886	CNIH3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CNIH3	VGNC	VGNC:39401
Macaca mulatta	CNIH3	VGNC	VGNC:71359
Felis catus	CNIH3	VGNC	VGNC:107860
Rattus norvegicus	CNIH3	RGD	RGD:1582859
Mus musculus	CNIH3	MGD	MGI:1920228
Bos taurus	CNIH3	VGNC	VGNC:27503

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