Dyrk1a - dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a Gene

Mus musculus

Also known as mmb; Dyrk; Mnbh; Mp86; Gm10783; D16Ertd272e; D16Ertd493e; 2310043O08Rik

Gene ID: 13548 | Gene type: protein coding

About Dyrk1a

Chromosome 16: 94,370,869-94,496,376 forward strand.GRCm39:CM001009.3

This gene has 6 transcripts (splice variants), 236 orthologues, 12 paralogues and is associated with 26 phenotypes. Ubiquitous expression in thymus adult (RPKM 12.2), whole brain E14.5 (RPKM 1.) and 28 other tissues.

Summary

Enables several functions, including identical protein binding activity; protein self-association; and Tau Protein binding activity. Involved in several processes, including negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of microtubule polymerization; and protein phosphorylation. Acts upstream of or within negative regulation of mRNA splicing, via spliceosome and peptidyl-tyrosine phosphorylation. Located in several cellular components, including axon; cytoskeleton; and dendrite. Part of ribonucleoprotein complex. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Used to study Down syndrome. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant non-syndromic intellectual disability 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A). [provided by Alliance of Genome Resources, Apr 2022]

Dyrk1a Products(6)

mRNA	Protein	Name
NM_001402792.1	NP_001389721.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 3
NM_001402793.1	NP_001389722.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 4
NM_001402791.1	NP_001389720.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1
NM_007890.2	NP_031916.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1
NM_001113389.1	NP_001106860.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1
NM_001347731.2	NP_001334660.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	9070862	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15199138	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	20123978	MGI
enables protein serine/threonine kinase activity	IGI IGI: Inferred from genetic interaction	17906291	MGI
enables tau protein binding	IPI IPI: Inferred from physical interaction	17906291	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in circadian rhythm	IMP IMP: Inferred from mutant phenotype	20123978	MGI
involved in negative regulation of DNA damage response, signal transduction by p53 class mediator	IDA IDA: Inferred from direct assay	20736167	MGI
acts upstream of or within negative regulation of mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	21470964	MGI
involved in negative regulation of microtubule polymerization	IDA IDA: Inferred from direct assay	17906291	MGI
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	20123978	MGI
involved in peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	20736167	MGI
involved in peptidyl-tyrosine autophosphorylation	IDA IDA: Inferred from direct assay	24327345	MGI
acts upstream of or within peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	21470964	MGI
involved in positive regulation of protein deacetylation	IDA IDA: Inferred from direct assay	20736167	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	21878370	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	21878370	MGI
located in cytoskeleton	IDA IDA: Inferred from direct assay	24327345	MGI
located in dendrite	IDA IDA: Inferred from direct assay	21878370	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9070862	MGI
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	21709260	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Dyrk1a Protein Structure

PKc_DYRK1

0
200
400
600
763 a.a.

Protein Preferred Names

Protein Names

dual specificity tyrosine-phosphorylation-regulated kinase 1A

dual specificity YAK1-related kinase

protein kinase minibrain homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (62)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115470	CLK-IN-T3	Inhibitor	98.63%	Unkown
HY-105309	GSK-626616	Inhibitor	99.77%	Unkown
HY-112296	T025		98.84%	Unkown
HY-132308	DYRK1-IN-1	Inhibitor	99.71%	Unkown
HY-111380	EHT 1610	Inhibitor	98.16%	Unkown
HY-101298	Paprotrain	Inhibitor	99.87%	Unkown
HY-142295	GNF2133	Inhibitor	98.49%	Unkown
HY-15951	ML167	Inhibitor	98.62%	Unkown
HY-146221	Dyrk1A-IN-5	Inhibitor	98.56%	Unkown
HY-108476	INDY	Inhibitor	99.51%	Unkown
HY-12838	RO5454948	Inhibitor	99.53%	Unkown
HY-15569	NU6102	Inhibitor	99.23%	Unkown
HY-101029	MBM-55		99.94%	Unkown
HY-135906	CK2/ERK8-IN-1		≥99.0%	Unkown
HY-111379	EHT 5372	Inhibitor	98.12%	Unkown
HY-129492	GNF4877	Inhibitor	99.41%	Unkown
HY-117049	Leucettine L41	Inhibitor	98.70%	Unkown
HY-147066	Dyrk1A-IN-4	Inhibitor	99.90%	Unkown
HY-144290	ARN25068	Inhibitor	99.66%	Unkown
HY-147060	Dyrk1A-IN-3	Inhibitor	99.96%	Unkown
HY-110052	TBCA	Inhibitor	99.45%	Unkown
HY-149262	CLK1-IN-3		98.03%	Unkown
HY-156816	ON 108600	Inhibitor	99.73%	Unkown
HY-12828A	KH-CB20	Inhibitor	99.80%	Unkown
HY-128758A	DYRKs-IN-1 hydrochloride	Inhibitor	99.71%	Unkown
HY-N12625	(R)-(+)-O-Demethylbuchenavianine	Inhibitor	98.67%	Unkown
HY-34222	7-Deazaguanine	Inhibitor	≥99.0%	Unkown
HY-RS04095	Dyrk1a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-128758	DYRKs-IN-1	Inhibitor	/	Unkown
HY-101029A	MBM-55S		/	Unkown
HY-128759	DYRKs-IN-2	Inhibitor	/	Unkown
HY-129449	AnnH31	Inhibitor	99.91%	Unkown
HY-139830	Dyrk1A-IN-1	Inhibitor	/	Unkown
HY-142295A	GNF2133 hydrochloride	Inhibitor	/	Unkown
HY-144614	JH-XVII-10		/	Unkown
HY-144617	JH-XIV-68-3	Inhibitor	/	Unkown
HY-144695	Dyrk1A/α-synuclein-IN-1	Inhibitor	/	Unkown
HY-144696	Dyrk1A/α-synuclein-IN-2	Inhibitor	/	Unkown
HY-144826	ZDWX-25	Inhibitor	/	Unkown
HY-146337	Dyrk1A/B-IN-1	Inhibitor	/	Unkown
HY-146586	Haspin-IN-1	Inhibitor	/	Unkown
HY-146587	Haspin-IN-2	Inhibitor	/	Unkown
HY-147760	Dyrk1A-IN-2	Inhibitor	/	Unkown
HY-150537	AChE/GSK-3β-IN-1	Inhibitor	/	Unkown
HY-152183	FINDY	Inhibitor	/	Unkown
HY-155723	Leucettinib-92	Inhibitor	/	Unkown
HY-157995	Dyrk1A-IN-7	Inhibitor	/	Unkown
HY-158212	Dyrk1A-IN-8	Inhibitor	/	Unkown
HY-159496	Dyrk1A-IN-10	Inhibitor	/	Unkown
HY-163514	hAChE-IN-8	Inhibitor	/	Unkown
HY-168195	DYR530		/	Unkown
HY-77324S	4-(Trifluoromethyl)aniline-d4	Inhibitor	99.23%	Unkown
HY-N2892	Aristolactam A IIIa	Inhibitor	/	Unkown
HY-RS04094	DYRK1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04096	Dyrk1a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-108475	ProINDY	Inhibitor	/	Unkown
HY-122989	Aristolactam BIII	Inhibitor	/	Unkown
HY-162107	Dyrk1A-IN-6	Inhibitor	/	Unkown
HY-162597	Dyrk1A-IN-9	Inhibitor	/	Unkown
HY-168194	DYR684	Degrader	/	Unkown
HY-168196	DYR684m		/	Unkown
HY-168265	Dyrk1A-IN-11	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dyrk1a	NCBI	NCBI:1859

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