Eed - embryonic ectoderm development Gene

Mus musculus

Also known as lusk; l7Rn5; l(7)5Rn

Gene ID: 13626 | Gene type: protein coding

About Eed

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of adaxial/abaxial pattern formation; and regulation of gene expression. Located in pronucleus and sex chromatin. Part of ESC/E(Z) complex and chromatin silencing complex. Is expressed in several structures, including branchial arch; early embryo; extraembryonic component; genitourinary system; and nervous system. Orthologous to human EED (embryonic ectoderm development). [provided by Alliance of Genome Resources, Apr 2022]

Eed Products(1)

mRNA	Protein	Name
NM_021876.3	NP_068676.1	polycomb protein EED

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	16687444	MGI
enables enzyme activator activity	IMP IMP: Inferred from mutant phenotype	15916951	MGI
enables methylated histone binding	IDA IDA: Inferred from direct assay	17107999	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9584197	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
involved in facultative heterochromatin formation	IDA IDA: Inferred from direct assay	20064375	MGI
acts upstream of or within genomic imprinting	IMP IMP: Inferred from mutant phenotype	12627233	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17107999	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24105743	MGI
acts upstream of or within oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	28041882	MGI
acts upstream of or within regulation of adaxial/abaxial pattern formation	IGI IGI: Inferred from genetic interaction	17107999	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of ESC/E(Z) complex	IDA IDA: Inferred from direct assay	20064375	MGI
part of chromatin silencing complex	IDA IDA: Inferred from direct assay	26658965	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9584197	MGI
located in pronucleus	IDA IDA: Inferred from direct assay	12900441	MGI
located in sex chromatin	IDA IDA: Inferred from direct assay	15525528	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

polycomb protein EED

lethal, Chr 7, Rinchik 5

Eed Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Eed	Q921E6	Ezh2	Mus musculus	Q61188-1	X-Ray Diffraction	17937919
Intra	Eed	Q921E6	Ezh2	Mus musculus	Q61188-1	GMS	17937919
Intra	Eed	Q921E6	Jarid2	Mus musculus	Q62315	Density Sedimentation	20064375
Intra	Eed	Q921E6	Jarid2	Mus musculus	Q62315	Anti Tag CoIP	20064376
Intra	Eed	Q921E6	Jarid2	Mus musculus	Q62315	GMS	20075857
Intra	Eed	Q921E6	Jarid2	Mus musculus	Q62315	Anti Tag CoIP	20064375
Intra	Eed	Q921E6	Ezh2	Mus musculus	Q61188	CoIP	9742080
Intra	Eed	Q921E6	Ezh2	Mus musculus	Q61188	Density Sedimentation	20064375
Intra	Eed	Q921E6	Ezh2	Mus musculus	Q61188	Anti Tag CoIP	20064376
Intra	Eed	Q921E6	Ezh2	Mus musculus	Q61188	IF	12900441
Intra	Eed	Q921E6	Ezh2	Mus musculus	Q61188	Anti Tag CoIP	20064375

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-103663	MAK683	Inhibitor	99.18%	Phase 2
HY-158102	ORIC-944	Inhibitor	99.90%	Phase 1
HY-139400	Pociredir	Inhibitor	99.97%	Phase 1
HY-139400A	Pociredir hydrochloride	Inhibitor	99.89%	Phase 1
HY-158102A	ORIC-944 TFA		/	Phase 1

Pre-clinical Phase

Bioactive Molecules (30)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101117	EED226	Inhibitor	99.56%	Unkown
HY-101512	A-395	Inhibitor	99.12%	Unkown
HY-130708	UNC6852	Inhibitor	99.09%	Unkown
HY-W014099	Boc-NH-C4-acid		99.85%	Unkown
HY-136977	EEDi-5285	Inhibitor	99.98%	Unkown
HY-130815A	MAK683-CH2CH2COOH hydrochloride	Inhibitor	98.03%	Unkown
HY-130614	PROTAC EED degrader-1	Inhibitor	98.27%	Unkown
HY-130615	PROTAC EED degrader-2	Inhibitor	99.90%	Unkown
HY-132922	EEDi-5273	Inhibitor	99.09%	Unkown
HY-130979	EED226-COOH		98.53%	Unkown
HY-157164	PROTAC EZH2 Degrader-2	Degrader	99.78%	Unkown
HY-W004697	Boc-GABA-OH		≥98.0%	Unkown
HY-158239	MS181	Inhibitor	98.36%	Unkown
HY-132970	EED ligand 1	Inhibitor	99.93%	Unkown
HY-114176B	(S,R,S)-AHPC-C4-NH2 dihydrochloride		/	Unkown
HY-130815	MAK683-CH2CH2COOH	Inhibitor	/	Unkown
HY-130816	(S,R,S)-AHPC-O-Ph-PEG1-NH2		96.97%	Unkown
HY-114176	(S,R,S)-AHPC-C4-NH2 hydrochloride		≥97.0%	Unkown
HY-P2266	SAH-EZH2	Inhibitor	99.50%	Unkown
HY-135045	(S,R,S)-AHPC-C4-COOH		≥95.0%	Unkown
HY-103663A	MAK683 hydrochloride	Inhibitor	/	Unkown
HY-130711A	(S,R,S)-AHPC-C3-NH2 TFA		/	Unkown
HY-114176A	(S,R,S)-AHPC-C4-NH2		/	Unkown
HY-130638	(S,R,S)-AHPC-O-Ph-PEG1-NH-Boc		/	Unkown
HY-130711	(S,R,S)-AHPC-C3-NH2		/	Unkown
HY-130637	Boc-NH-PEG1-Ph-O-CH2COOH		/	Unkown
HY-130711C	(S,R,S)-AHPC-C3-NH2 dihydrochloride		/	Unkown
HY-160924	MS147	Inhibitor	/	Unkown
HY-RS04173	EED Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-124660A	A-395N		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eed	NCBI	NCBI:8726

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