EED - embryonic ectoderm development Gene

Homo sapiens

Also known as HEED; COGIS; WAIT1

Gene ID: 8726 | Gene type: protein coding

About EED

Cytogenetic location: 11q14.2 Genomic coordinates (GRCh38): 11:86,244,753-86,287,615 (from NCBI)

This gene has 13 transcripts (splice variants), 208 orthologues and is associated with 68 phenotypes. Ubiquitous expression in lymph node (RPKM 3.3), appendix (RPKM 2.2) and 25 other tissues.

Summary

This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of Integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of Integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

EED Products(3)

mRNA	Protein	Name
NM_001308007.2	NP_001294936.1	polycomb protein EED isoform c
NM_001330334.2	NP_001317263.1	polycomb protein EED isoform d
NM_003797.5	NP_003788.2	polycomb protein EED isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme activator activity	IDA IDA: Inferred from direct assay	15385962	GOA
enables enzyme activator activity	IMP IMP: Inferred from mutant phenotype	28229514	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	11124122	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16357870	GOA
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	29628311	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of ESC/E(Z) complex	IDA IDA: Inferred from direct assay	15385962	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EED Protein Structure

WD40

0
100
200
300
400
441 a.a.

Protein Preferred Names

Protein Names

polycomb protein EED

WD protein associating with integrin cytoplasmic tails 1

EED Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EED	O75530	SUZ12	Homo sapiens	Q15022	Anti Tag CoIP	26496610
Intra	EED	O75530	SUZ12	Homo sapiens	Q15022	Anti Bait CoIP	22439931
Intra	EED	O75530	SUZ12	Homo sapiens	Q15022	TAP	27705803
Intra	EED	O75530	SUZ12	Homo sapiens	Q15022	Anti Tag CoIP	21078963
Intra	EED	O75530	ASXL1	Homo sapiens	Q8IXJ9	Anti Bait CoIP	22897849
Intra	EED	O75530	RACK1	Homo sapiens	P63244	Y2H	20080539
Intra	EED	O75530	DDB1	Homo sapiens	Q16531	Anti Bait CoIP	17041588
Intra	EED	O75530	CCT3	Homo sapiens	P49368	Crosslink	30021884
Intra	EED	O75530	CCT3	Homo sapiens	P49368	TAP	27705803
Intra	EED	O75530	EZH2	Homo sapiens	Q15910	Anti Bait CoIP	22439931
Intra	EED	O75530	EZH2	Homo sapiens	Q15910	Anti Tag CoIP	26496610
Intra	EED	O75530	EZH2	Homo sapiens	Q15910	Anti Bait CoIP	22897849
Intra	EED	O75530	EZH2	Homo sapiens	Q15910	TAP	27705803
Intra	EED	O75530	DNMT1	Homo sapiens	P26358	Anti Bait CoIP	16357870
Intra	EED	O75530	DNMT3B	Homo sapiens	Q9UBC3	Anti Bait CoIP	16357870
Intra	EED	O75530	DNMT3B	Homo sapiens	Q9UBC3	Pull Down	16357870
Intra	EED	O75530	EZH1	Homo sapiens	Q92800	TAP	27705803
Intra	EED	O75530	DNMT3A	Homo sapiens	Q9Y6K1	Anti Bait CoIP	16357870
Cross	EED	O75530	Smpd3	Mus musculus	Q9JJY3	Anti Tag CoIP	20080539

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EED Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74179	EED Protein, Human (sf9, His-GST)	O75530 (M1-R441)	≥95%

Related Diseases

Diseases

Alias

Cohen-Gibson Syndrome

COGIS

Weaver Syndrome

Wss	Weaver-Smith Syndrome
WVS	Weaver-Like Syndrome
Weaver-Williams Syndrome	Camptodactyly-Overgrowth-Unusual Facies Syndrome
Camptodactyly - Overgrowth - Unusual Facies	Ezh2 Related Overgrowth
Overgrowth Syndrome With Accelerated Skeletal Maturation, Unusual Facies, And Camptodactyly	Weaver Smith Syndrome
Weaver Like Syndrome	Weaver Williams Syndrome
Camptodactyly-Overgrowth-Unusual Facies	Weaver Syndrome 1
Weaver Syndrome 2	Wvs1
Wvs2

Atypical Neurofibroma

Diffuse Large B-Cell Lymphoma

Dlbcl	Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Large B-Cell Diffuse Lymphoma	Lymphoma, Large B-Cell, Diffuse
Dlbcl - [Diffuse Large B-Cell Lymphoma]	Diffuse Large Beta Cell Lymphoma

Fallopian Tube Endometriosis

Endometriosis Of Fallopian Tube

Adenomyosis Of Fallopian Tube

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-103663	MAK683	Inhibitor	99.18%	Phase 2
HY-139400	Pociredir	Inhibitor	99.97%	Phase 1
HY-158102	ORIC-944	Inhibitor	99.90%	Phase 1
HY-139400A	Pociredir hydrochloride	Inhibitor	99.89%	Phase 1

Pre-clinical Phase

Bioactive Molecules (31)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101117	EED226	Inhibitor	99.65%	Unkown
HY-101512	A-395	Inhibitor	99.12%	Unkown
HY-130708	UNC6852	Inhibitor	99.09%	Unkown
HY-130979	EED226-COOH		98.53%	Unkown
HY-130815A	MAK683-CH2CH2COOH hydrochloride	Inhibitor	98.03%	Unkown
HY-W014099	Boc-NH-C4-acid		99.85%	Unkown
HY-130615	PROTAC EED degrader-2	Inhibitor	99.90%	Unkown
HY-136977	EEDi-5285	Inhibitor	99.98%	Unkown
HY-130614	PROTAC EED degrader-1	Inhibitor	98.27%	Unkown
HY-W004697	Boc-GABA-OH		≥98.0%	Unkown
HY-132922	EEDi-5273	Inhibitor	99.09%	Unkown
HY-157164	PROTAC EZH2 Degrader-2	Degrader	99.78%	Unkown
HY-158102A	ORIC-944 TFA	Inhibitor	/	Unkown
HY-158239	MS181	Inhibitor	98.36%	Unkown
HY-114176B	(S,R,S)-AHPC-C4-NH2 dihydrochloride		/	Unkown
HY-132970	EED ligand 1	Inhibitor	99.93%	Unkown
HY-130815	MAK683-CH2CH2COOH	Inhibitor	/	Unkown
HY-130816	(S,R,S)-AHPC-O-Ph-PEG1-NH2		96.97%	Unkown
HY-114176	(S,R,S)-AHPC-C4-NH2 hydrochloride		≥97.0%	Unkown
HY-103663A	MAK683 hydrochloride	Inhibitor	/	Unkown
HY-130711A	(S,R,S)-AHPC-C3-NH2 TFA		/	Unkown
HY-114176A	(S,R,S)-AHPC-C4-NH2		/	Unkown
HY-130638	(S,R,S)-AHPC-O-Ph-PEG1-NH-Boc		/	Unkown
HY-130711	(S,R,S)-AHPC-C3-NH2		/	Unkown
HY-130637	Boc-NH-PEG1-Ph-O-CH2COOH		/	Unkown
HY-130711C	(S,R,S)-AHPC-C3-NH2 dihydrochloride		/	Unkown
HY-160924	MS147	Inhibitor	/	Unkown
HY-P2266	SAH-EZH2	Inhibitor	/	Unkown
HY-RS04173	EED Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-124660A	A-395N		/	Unkown
HY-135045	(S,R,S)-AHPC-C4-COOH		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	EED	VGNC	VGNC:28332
Mus musculus	EED	MGD	MGI:95286
Felis catus	EED	VGNC	VGNC:61731
Macaca mulatta	EED	VGNC	VGNC:72162
Rattus norvegicus	EED	RGD	RGD:1309782
Canis familiaris	EED	VGNC	VGNC:40206
Others	EED	NCBI

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