Egf - epidermal growth factor Gene

Mus musculus

Gene ID: 13645 | Gene type: protein coding

About Egf

Summary

This gene encodes epidermal growth factor (EGF), the founding member of the EGF family of growth factors that are implicated in cell proliferation and differentiation. The encoded protein can localize to the membrane and function in juxtacrine signaling or undergo proteolytic processing to generate a soluble form of the hormone. Mice lacking the encoded protein do not exhibit an abnormal phenotype but transgenic mice overexpressing the encoded protein exhibit hypospermatogenesis. [provided by RefSeq, Jul 2016]

Egf Products(3)

mRNA	Protein	Name
NM_001310737.1	NP_001297666.1	pro-epidermal growth factor isoform 2
NM_001329594.1	NP_001316523.1	pro-epidermal growth factor isoform 3
NM_010113.4	NP_034243.2	pro-epidermal growth factor isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables epidermal growth factor receptor binding	IDA IDA: Inferred from direct assay	6315706	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17626015	MGI
enables receptor ligand activity	IDA IDA: Inferred from direct assay	6248866	MGI
enables transmembrane receptor protein tyrosine kinase activator activity	IDA IDA: Inferred from direct assay	6248866	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERBB2-EGFR signaling pathway	IDA IDA: Inferred from direct assay	22822073	MGI
acts upstream of or within branching morphogenesis of an epithelial tube	IDA IDA: Inferred from direct assay	15831470	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	15509736	MGI
acts upstream of cerebellar granule cell precursor proliferation	IDA IDA: Inferred from direct assay	10027293	MGI
acts upstream of or within epidermal growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	6315706	MGI
involved in epidermal growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	6248866	MGI
acts upstream of or within epidermal growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	7641815	MGI
acts upstream of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	15509736	MGI
acts upstream of or within mammary gland alveolus development	IGI IGI: Inferred from genetic interaction	10331984	MGI
involved in negative regulation of cholesterol efflux	IDA IDA: Inferred from direct assay	20037141	MGI
acts upstream of or within peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	14561752	MGI
involved in positive regulation of DNA binding	IDA IDA: Inferred from direct assay	15156153	MGI
acts upstream of or within positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	9030684	MGI
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	8702723	MGI
acts upstream of or within positive regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	7641815	MGI
acts upstream of or within positive regulation of cerebellar granule cell precursor proliferation	IDA IDA: Inferred from direct assay	10027293	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	15509736	MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	21186272	MGI
acts upstream of or within positive regulation of protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	7678348	MGI
involved in positive regulation of ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	20208556	MGI
acts upstream of or within regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	11940581	MGI
involved in regulation of receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	15156153	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in extracellular space	IDA IDA: Inferred from direct assay	6248866	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	7641815	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17626015	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pro-epidermal growth factor

Pro-epidermal growth factor precursor (EGF)

Recombinant Egf Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7067	EGF Protein, Mouse	P01132 (N977-R1029)	≥95%
HY-P70590	EGF Protein, Mouse (His)	P01132 (N977-R1029)	≥95%
HY-P72983	EGF Protein, Mouse (HEK293)	P01132 (N977-R1029)	≥95%
HY-P72984	EGF Protein, Mouse (P.pastoris)	P01132 (N977-R1029)	≥95%
HY-P72985	EGF Protein, Mouse (HEK293, Fc)	P01132 (N977-R1029)	≥95%
HY-P70590AF	Animal-Free EGF Protein, Mouse (His)	P01132 (N977-R1029)	≥95%

Related Agents

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-50895	Gefitinib		99.95%	Yes
HY-50895A	Gefitinib hydrochloride	Inhibitor	99.85%	Yes
HY-50895R	Gefitinib (Standard)		/	Unkown
HY-50895B	Gefitinib dihydrochloride		/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99041	Panitumumab	Inhibitor	98.80%	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12872	Nazartinib	Inhibitor	99.03%	Phase 2
HY-N6674	Diazepinomicin		98.04%	Phase 2
HY-12872A	Nazartinib mesylate	Inhibitor	/	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99155	Zalutumumab		98.34%	Phase 3

Pre-clinical Phase

Bioactive Molecules (54)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18723	Yoda 1		99.98%	Unkown
HY-13595	Chrysophanol	Inhibitor	99.77%	Unkown
HY-145967	FT709	Inhibitor	99.81%	Unkown
HY-104064	1A-116		99.72%	Unkown
HY-19713	LJI308	Inhibitor	99.07%	Unkown
HY-101957	AG 1295	Inhibitor	99.90%	Unkown
HY-13896	PD168393		98.58%	Unkown
HY-16160	Cysmethynil		99.87%	Unkown
HY-101219	VEGFR-IN-1	Inhibitor	98.42%	Unkown
HY-P0320	EGF Receptor Substrate 2 (Phospho-Tyr5)		99.90%	Unkown
HY-103440	EGFR/ErbB-2/ErbB-4 inhibitor-3	Inhibitor	98.19%	Unkown
HY-124674A	CCT365623 hydrochloride		98.07%	Unkown
HY-101960A	Tyrphostin A51	Inhibitor	≥99.0%	Unkown
HY-112345	PD-089828	Inhibitor	98.07%	Unkown
HY-101042	AG-494	Inhibitor	99.31%	Unkown
HY-132126	SPHINX	Inhibitor	99.87%	Unkown
HY-100923	H-9 Dihydrochloride	Inhibitor	98.98%	Unkown
HY-101429	RG13022	Inhibitor	96.74%	Unkown
HY-116111	AG 370	Inhibitor	≥97.0%	Unkown
HY-12872B	Nazartinib S-enantiomer		98.66%	Unkown
HY-133779	Gefitinib impurity 5		99.46%	Unkown
HY-50895S1	Gefitinib-d6		≥98.0%	Unkown
HY-E70229	Cyclooxygenase 1, sheep		/	Unkown
HY-P0320B	EGF Receptor Substrate 2 (Phospho-Tyr5) (acetate)		99.00%	Unkown
HY-P1985A	Notch 1 TFA		95.03%	Unkown
HY-P2673	Lys-Arg-Thr-Leu-Arg-Arg		/	Unkown
HY-P2673A	Lys-Arg-Thr-Leu-Arg-Arg acetate		/	Unkown
HY-W013852	PKC-IN-6	Inhibitor	99.63%	Unkown
HY-101756	SDZ281-977		98.00%	Unkown
HY-100663	Gefitinib impurity 2		99.56%	Unkown
HY-101960	(Z)-Tyrphostin A51	Inhibitor	/	Unkown
HY-108931	AG 1406	Inhibitor	99.03%	Unkown
HY-118175	RG 14921	Inhibitor	/	Unkown
HY-120857	BPIQ-II hydrochloride	Inhibitor	/	Unkown
HY-122564	Pyrimidyn 7	Inhibitor	/	Unkown
HY-124152	3,4-Dephostatin	Inhibitor	/	Unkown
HY-129510	4-Methyl erlotinib	Inhibitor	/	Unkown
HY-131257	Gefitinib impurity 1		99.59%	Unkown
HY-13595R	Chrysophanol (Standard)	Inhibitor	/	Unkown
HY-147279	Milpocitide		/	Unkown
HY-149352	DG1	Inhibitor	/	Unkown
HY-149517	EGFR/BRAFV600E-IN-2	Inhibitor	/	Unkown
HY-150687	ZINC12409120	Inhibitor	/	Unkown
HY-N3634	Corylifol C		/	Unkown
HY-P0320A	EGF Receptor Substrate 2 (Phospho-Tyr5) (TFA)		/	Unkown
HY-P10301	CXCL9(74-103)		/	Unkown
HY-P10697	VH4127	Modulator	/	Unkown
HY-P3918	EGF-R (661-681) T669 Peptide		/	Unkown
HY-RS04204	EGF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-114667	Lavendustin C6	Inhibitor	/	Unkown
HY-117523	(Z)-RG-13022	Inhibitor	/	Unkown
HY-50895S2	Gefitinib-d3		/	Unkown
HY-N14910	Actiketal	Inhibitor	/	Unkown
HY-RS22928	Egf Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Egf	NCBI	NCBI:1950
Canis familiaris	Egf	NCBI	NCBI:403657
Macaca fascicularis	Egf	NCBI	NCBI:102123415
Susscrofa domestica	Egf	NCBI
Leporidae	Egf	NCBI
Rattus norvegicus	Egf	NCBI	NCBI:25313
Macaca mulatta	Egf	NCBI	NCBI:698619

Name
Email *

	Sorry, but the email address you supplied was invalid.