2. Gene
  3. EGF - Egf epidermal growth factor Gene

EGF - Egf epidermal growth factor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 25313 | Gene type: protein coding

About EGF

Summary

Enables epidermal growth factor receptor binding activity. Involved in several processes, including positive regulation of DNA biosynthetic process; positive regulation of ERK1 and ERK2 cascade; and positive regulation of fibroblast proliferation. Acts upstream of or within regulation of protein transport. Located in extracellular space. Used to study perinatal necrotizing enterocolitis. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system Cancer (multiple); high grade glioma (multiple); lung non-small cell carcinoma (multiple); and primary hypomagnesemia (multiple). Orthologous to human EGF (epidermal growth factor). [provided by Alliance of Genome Resources, Apr 2022]

EGF Products(1)

mRNA Protein Name
NM_012842.2 NP_036974.2 pro-epidermal growth factor precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables epidermal growth factor receptor binding IDA
IDA: Inferred from direct assay
2260661 RGD
Biological Process GO Annotation Evidence Reference Source
involved in epidermal growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
2260661 RGD
involved in kidney development IEP
IEP: Inferred from expression pattern
1570198 RGD
involved in positive regulation of DNA biosynthetic process IDA
IDA: Inferred from direct assay
3093142 RGD
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
17310240 RGD
involved in positive regulation of fibroblast proliferation IDA
IDA: Inferred from direct assay
3093142 RGD
acts upstream of or within regulation of protein transport IDA
IDA: Inferred from direct assay
19723622 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
3257897 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pro-epidermal growth factor

Recombinant EGF Proteins

Cat. No. Product Name Accession Purity
HY-P7092 EGF Protein, Rat P07522/NP_036974.1 (N974-R1026) ≥95%
HY-P7092A EGF Protein, Rat (CHO) P07522 (N974-R1026) ≥95%
HY-P7092Y EGF Protein, Rat (Tag Free, Solution) P07522 (N974-R1026) ≥95%

Related Agents

Approval
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50895 Gefitinib 99.94% Yes
HY-50895A Gefitinib hydrochloride Inhibitor 99.85% Yes
HY-50895R Gefitinib (Standard) / Unkown
HY-50895B Gefitinib dihydrochloride / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99041 Panitumumab Inhibitor 98.80% Unkown
Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-12872 Nazartinib Inhibitor 99.03% Phase 2
HY-N6674 Diazepinomicin 98.04% Phase 2
HY-12872A Nazartinib mesylate Inhibitor / Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99155 Zalutumumab 98.26% Phase 3
Pre-clinical Phase
Bioactive Molecules (48)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18723 Yoda 1 99.98% Unkown
HY-13595 Chrysophanol Inhibitor 99.77% Unkown
HY-145967 FT709 Inhibitor 99.81% Unkown
HY-104064 1A-116 99.79% Unkown
HY-19713 LJI308 Inhibitor 99.07% Unkown
HY-101957 AG 1295 Inhibitor 99.90% Unkown
HY-13896 PD168393 98.58% Unkown
HY-16160 Cysmethynil 99.87% Unkown
HY-101219 VEGFR-IN-1 Inhibitor 98.42% Unkown
HY-103440 EGFR/ErbB-2/ErbB-4 inhibitor-3 Inhibitor 98.19% Unkown
HY-P0320 EGF Receptor Substrate 2 (Phospho-Tyr5) 99.90% Unkown
HY-101042 AG-494 Inhibitor 99.31% Unkown
HY-124674A CCT365623 hydrochloride 98.07% Unkown
HY-101429 RG13022 Inhibitor 96.74% Unkown
HY-101960A Tyrphostin A51 Inhibitor ≥99.0% Unkown
HY-112345 PD-089828 Inhibitor 98.07% Unkown
HY-132126 SPHINX Inhibitor 99.87% Unkown
HY-100923 H-9 Dihydrochloride Inhibitor 98.98% Unkown
HY-116111 AG 370 Inhibitor ≥97.0% Unkown
HY-12872B Nazartinib S-enantiomer 98.66% Unkown
HY-E70229 Cyclooxygenase 1, sheep / Unkown
HY-P0320B EGF Receptor Substrate 2 (Phospho-Tyr5) (acetate) 99.00% Unkown
HY-P1985A Notch 1 TFA 95.03% Unkown
HY-P2673 Lys-Arg-Thr-Leu-Arg-Arg / Unkown
HY-101756 SDZ281-977 98.00% Unkown
HY-100663 Gefitinib impurity 2 99.56% Unkown
HY-101960 (Z)-Tyrphostin A51 Inhibitor / Unkown
HY-108931 AG 1406 Inhibitor 99.03% Unkown
HY-118175 RG 14921 / Unkown
HY-122564 Pyrimidyn 7 Inhibitor / Unkown
HY-124152 3,4-Dephostatin Inhibitor / Unkown
HY-129510 4-Methyl erlotinib Inhibitor / Unkown
HY-131257 Gefitinib impurity 1 99.59% Unkown
HY-133779 Gefitinib impurity 5 97.43% Unkown
HY-13595R Chrysophanol (Standard) Inhibitor / Unkown
HY-147279 Milpocitide / Unkown
HY-149352 DG1 Inhibitor / Unkown
HY-149517 EGFR/BRAFV600E-IN-2 Inhibitor / Unkown
HY-150687 ZINC12409120 Inhibitor / Unkown
HY-N3634 Corylifol C / Unkown
HY-P0320A EGF Receptor Substrate 2 (Phospho-Tyr5) (TFA) / Unkown
HY-P10301 CXCL9(74-103) / Unkown
HY-P10697 VH4127 Modulator / Unkown
HY-P3918 EGF-R (661-681) T669 Peptide / Unkown
HY-RS04204 EGF Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-114667 Lavendustin C6 Inhibitor / Unkown
HY-117523 (Z)-RG-13022 Inhibitor / Unkown
HY-120857 BPIQ-II hydrochloride / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens EGF NCBI NCBI:1950
Canis familiaris EGF NCBI NCBI:403657
Macaca fascicularis EGF NCBI NCBI:102123415
Mus musculus EGF NCBI NCBI:13645
Susscrofa domestica EGF NCBI
Leporidae EGF NCBI
Macaca mulatta EGF NCBI NCBI:698619