Hdac5 - histone deacetylase 5 Gene

Mus musculus

Also known as HD5; Hdac4; mHDA1; mKIAA0600

Gene ID: 15184 | Gene type: protein coding

About Hdac5

Chromosome 11: 102,085,258-102,120,992 reverse strand.GRCm39:CM001004.3

This gene has 20 transcripts (splice variants), 194 orthologues, 10 paralogues and is associated with 1 phenotype. Ubiquitous expression in lung adult (RPKM 2.5), adrenal adult (RPKM 19.) and 28 other tissues.

Summary

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; transcription corepressor activity; and transcription corepressor binding activity. Involved in several processes, including cellular response to fluid shear stress; positive regulation of cell population proliferation; and regulation of myotube differentiation. Acts upstream of or within several processes, including negative regulation of macromolecule metabolic process; negative regulation of osteoblast differentiation; and osteoblast development. Located in several cellular components, including axonal growth cone; chromatin; and nuclear body. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including central nervous system; early embryo; head bone; sensory organ; and upper arm. Orthologous to human HDAC5 (histone deacetylase 5). [provided by Alliance of Genome Resources, Apr 2022]

Hdac5 Products(18)

mRNA	Protein	Name
NM_010412.4	NP_034542.3	histone deacetylase 5 isoform 2
NM_001284250.2	NP_001271179.1	histone deacetylase 5 isoform 5
NM_001405239.1	NP_001392168.1	histone deacetylase 5 isoform 11
NM_001405237.1	NP_001392166.1	histone deacetylase 5 isoform 10
NM_001405234.1	NP_001392163.1	histone deacetylase 5 isoform 8
NM_001284248.2	NP_001271177.1	histone deacetylase 5 isoform 3
NM_001405241.1	NP_001392170.1	histone deacetylase 5 isoform 13
NM_001405233.1	NP_001392162.1	histone deacetylase 5 isoform 7
NM_001405242.1	NP_001392171.1	histone deacetylase 5 isoform 13
NM_001405232.1	NP_001392161.1	histone deacetylase 5 isoform 6
NM_001405238.1	NP_001392167.1	histone deacetylase 5 isoform 11
NM_001361596.2	NP_001348525.1	histone deacetylase 5 isoform 4
NM_001405235.1	NP_001392164.1	histone deacetylase 5 isoform 9
NM_001405236.1	NP_001392165.1	histone deacetylase 5 isoform 9
NM_001284249.2	NP_001271178.1	histone deacetylase 5 isoform 4
NM_001405240.1	NP_001392169.1	histone deacetylase 5 isoform 12
NM_001405244.1	NP_001392173.1	histone deacetylase 5 isoform 14
NM_001077696.2	NP_001071164.1	histone deacetylase 5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	10748098	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	20181743	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20181743	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	20123967	MGI
enables histone deacetylase activity	IDA IDA: Inferred from direct assay	10640276	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10640276	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	17468767	MGI
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	10640276	MGI
enables transcription corepressor activity	IGI IGI: Inferred from genetic interaction	15990875	MGI
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	12007404	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to fluid shear stress	IDA IDA: Inferred from direct assay	20181743	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	15367668	MGI
acts upstream of or within multicellular organismal response to stress	IMP IMP: Inferred from mutant phenotype	17988634	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16260608	MGI
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23926128	MGI
acts upstream of or within negative regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	15990875	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10640276	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15601857	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20181743	MGI
acts upstream of or within osteoblast development	IMP IMP: Inferred from mutant phenotype	15990875	MGI
acts upstream of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	15990875	MGI
involved in positive regulation of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	20123967	MGI
involved in positive regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	20123967	MGI
involved in regulation of myotube differentiation	IDA IDA: Inferred from direct assay	17468767	MGI
acts upstream of or within regulation of skeletal muscle fiber development	IGI IGI: Inferred from genetic interaction	17786239	MGI
acts upstream of or within regulation of skeletal muscle fiber differentiation	IGI IGI: Inferred from genetic interaction	17786239	MGI
involved in renal tubule morphogenesis	IMP IMP: Inferred from mutant phenotype	20181743	MGI
acts upstream of or within response to cocaine	IDA IDA: Inferred from direct assay	17988634	MGI
acts upstream of or within response to cocaine	IMP IMP: Inferred from mutant phenotype	17988634	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription repressor complex	IDA IDA: Inferred from direct assay	12007404	MGI
located in axonal growth cone	IDA IDA: Inferred from direct assay	26157139	MGI
located in chromatin	IDA IDA: Inferred from direct assay	12007404	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	11081517	MGI
located in cytosol	IDA IDA: Inferred from direct assay	18198354	MGI
located in nuclear body	IDA IDA: Inferred from direct assay	11641275	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	10640276	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11081517	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hdac5 Protein Structure

ClassIIa_HDAC_Gln-rich-N

HDAC5

0
200
400
600
800
1000
1114 a.a.

Protein Preferred Names

Protein Names

histone deacetylase 5

histone deacetylase 4

histone deacetylase mHDA1

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14842	Givinostat	Inhibitor	98.16%	Yes
HY-13322	Pracinostat	Inhibitor	99.82%	Yes

Clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14842B	Givinostat hydrochloride monohydrate	Inhibitor	≥98.0%	Phase 3
HY-14842A	Givinostat hydrochloride	Inhibitor	98.06%	Phase 3
HY-16026	Ricolinostat	Inhibitor	99.83%	Phase 2
HY-15433	Quisinostat	Inhibitor	98.02%	Phase 2
HY-13522	Fimepinostat	Inhibitor	99.95%	Phase 2
HY-15433A	Quisinostat dihydrochloride	Inhibitor	99.05%	Phase 2
HY-16012A	Domatinostat	Inhibitor	99.43%	Phase 2
HY-16012	Domatinostat tosylate	Inhibitor	99.66%	Phase 2
HY-10223	CUDC-101	Inhibitor	99.05%	Phase 1

Pre-clinical Phase

Bioactive Molecules (31)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18361	TMP195	Inhibitor	99.68%	Unkown
HY-18998	LMK-235	Inhibitor	99.61%	Unkown
HY-13428	Tubacin	Inhibitor	99.54%	Unkown
HY-18360	TMP269	Inhibitor	98.05%	Unkown
HY-16699	Nexturastat A	Inhibitor	98.28%	Unkown
HY-119939	CHDI-390576	Inhibitor	98.07%	Unkown
HY-115475	SW-100	Inhibitor	99.93%	Unkown
HY-112719	BRD 4354	Inhibitor	99.66%	Unkown
HY-143248	KR-39038	Inhibitor	99.48%	Unkown
HY-126330	SS-208	Inhibitor	99.00%	Unkown
HY-149285	NT160	Inhibitor	99.58%	Unkown
HY-112719B	BRD 4354 ditrifluoroacetate	Inhibitor	98.06%	Unkown
HY-117554	BRD9757	Inhibitor	99.75%	Unkown
HY-146678	HDAC6-IN-5	Inhibitor	/	Unkown
HY-150109	Purinostat mesylate	Inhibitor	99.45%	Unkown
HY-146679	HDAC6-IN-6	Inhibitor	/	Unkown
HY-161778	ZG-126	Inhibitor	/	Unkown
HY-15144B	(S)-Trichostatin A	Inhibitor	/	Unkown
HY-149208	HDAC-IN-53	Inhibitor	/	Unkown
HY-152226	MC2590	Inhibitor	/	Unkown
HY-150595	HDAC6-IN-10	Inhibitor	/	Unkown
HY-163803	CM-444	Inhibitor	/	Unkown
HY-147934	HDAC8-IN-3	Inhibitor	/	Unkown
HY-146684	HDAC-IN-36	Inhibitor	/	Unkown
HY-124946	C1A	Inhibitor	/	Unkown
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	Unkown
HY-157740	XSJ-10	Inhibitor	/	Unkown
HY-146351	HDAC-IN-38	Inhibitor	/	Unkown
HY-152225	MC2625	Inhibitor	/	Unkown
HY-148624	CHDI-00484077	Inhibitor	/	Unkown
HY-135714	Bavarostat	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hdac5	NCBI	NCBI:10014

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