2. Gene
  3. VKORC1L1 - vitamin K epoxide reductase complex subunit 1 like 1 Gene

VKORC1L1 - vitamin K epoxide reductase complex subunit 1 like 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 154807 | Gene type: protein coding

About VKORC1L1

Cytogenetic location: 7q11.21 Genomic coordinates (GRCh38): 7:65,865,772-65,959,558 (from NCBI)

This gene has 4 transcripts (splice variants), 205 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 25.2), lung (RPKM 7.7) and 23 other tissues.

Summary

This gene encodes an Enzyme important in the vitamin K cycle, which is involved in the carboxylation of glutamate residues present in vitamin K-dependent proteins. The encoded Enzyme catalyzes the de-epoxidation of vitamin K 2,3-epoxide. Oxidative stress may upregulate expression of this gene and the encoded protein may protect cells and membrane proteins form oxidative damage. This gene and a related gene (Gene ID: 79001) may have arisen by gene duplication of an ancestral gene. [provided by RefSeq, Oct 2016]

VKORC1L1 Products(2)

mRNA Protein Name
NM_001284342.3 NP_001271271.1 vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 2
NM_173517.6 NP_775788.2 vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 1

VKORC1L1 Protein Structure

VKOR

VKOR: Vitamin K epoxide reductase family (16 - 159)

  • 0
  • 100
  • 176 a.a.
Protein Preferred Names Protein Names

vitamin K epoxide reductase complex subunit 1-like protein 1

VKORC1-like protein 1

Related Diseases

Diseases Alias
Coumarin Resistance

Warfarin Resistance

Warfarin Sensitivity

Coumadin Sensitivity

Warfarin Response

Poor Metabolism Of Coumarin

Coumarin, Poor Metabolism Of

CMRES
Hereditary Combined Deficiency Of Vitamin K-Dependent Clotting Factors

Hereditary Combined Deficiency Of Factors Ii, Vii, Ix And X

Vkcfd
Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, 2

VKCFD2

Combined Deficiency Of Vitamin K-Dependent Clotting Factors 2

Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15660 VKORC1L1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus VKORC1L1 MGD MGI:1916818
Canis familiaris VKORC1L1 VGNC VGNC:82304
Rattus norvegicus VKORC1L1 RGD RGD:1303249
Bos taurus VKORC1L1 VGNC VGNC:58426
Macaca mulatta VKORC1L1 VGNC VGNC:79322