CYP2C8 - cytochrome P450 family 2 subfamily C member 8 Gene

Homo sapiens

Also known as CPC8; CYPIIC8; CYP2C8DM; MP-12/MP-20

Gene ID: 1558 | Gene type: protein coding

About CYP2C8

Cytogenetic location: 10q23.33 Genomic coordinates (GRCh38): 10:95,036,772-95,069,497 (from NCBI)

This gene has 12 transcripts (splice variants), 30 orthologues, 15 paralogues and is associated with 59 phenotypes. Restricted expression toward liver (RPKM 350.3).

Summary

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The Enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of Cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

CYP2C8 Products(4)

mRNA	Protein	Name
NM_000770.3	NP_000761.3	cytochrome P450 2C8 isoform a precursor
NM_001198853.1	NP_001185782.1	cytochrome P450 2C8 isoform b
NM_001198854.1	NP_001185783.1	cytochrome P450 2C8 isoform c
NM_001198855.1	NP_001185784.1	cytochrome P450 2C8 isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables arachidonate epoxygenase activity	IDA IDA: Inferred from direct assay	7574697	GOA
enables caffeine oxidase activity	IDA IDA: Inferred from direct assay	18619574	GOA
enables estrogen 16-alpha-hydroxylase activity	IDA IDA: Inferred from direct assay	14559847	GOA
enables monooxygenase activity	IDA IDA: Inferred from direct assay	15766564	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA
enables retinoic acid 4-hydroxylase activity	IDA IDA: Inferred from direct assay	11093772	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in epoxygenase P450 pathway	IDA IDA: Inferred from direct assay	7574697	GOA
involved in estrogen metabolic process	IDA IDA: Inferred from direct assay	12865317	GOA
involved in icosanoid biosynthetic process	IDA IDA: Inferred from direct assay	15766564	GOA
involved in lipid hydroxylation	IDA IDA: Inferred from direct assay	14559847	GOA
involved in organic acid metabolic process	IDA IDA: Inferred from direct assay	19651758	GOA
involved in oxidative demethylation	IDA IDA: Inferred from direct assay	18619574	GOA
involved in retinoic acid metabolic process	IDA IDA: Inferred from direct assay	11093772	GOA
involved in steroid metabolic process	IDA IDA: Inferred from direct assay	14559847	GOA
involved in xenobiotic catabolic process	IDA IDA: Inferred from direct assay	18619574	GOA
involved in xenobiotic metabolic process	IDA IDA: Inferred from direct assay	19651758	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYP2C8 Protein Structure

p450

0
100
200
300
400
490 a.a.

Protein Preferred Names

Protein Names

cytochrome P450 2C8

P450 form 1

Related Diseases

Diseases

Alias

Drug Metabolism, Altered, Cyp2c8-Related

{Drug Metabolism, Altered, Cyp2c8-Related}

Osteonecrosis Of The Jaw

Sulfamethoxazole Allergy

Smx Allergy	Smz Allergy
Sulphamethoxazole Allergy

Gout

Gouty Arthritis	Articular Gout
Gouty Arthropathy	Arthritis, Gouty
Arthritis Gouty	Idiopathic Gout
Idiopathic Gout, Unspecified Site	Gouty Bursitis
Uratic Arthritis	Gout Nos
Gouty	Gouty Diathesis

Osteonecrosis

Bone Necrosis	Avascular Necrosis Of Bone
Aseptic Necrosis	Necrosis Of Bone Nos
Aseptic Osteonecrosis	Aseptic Necrosis Of Bone, Site Unspecified
Aseptic Or Avascular Bone Necrosis	Aseptic Necrosis Of Bone
Necrotic Bone	Necrotizing Bone
Spontaneous Osteonecrosis	Osteoradionecrosis

Hypertrophy Of Tongue Papillae

Tongue Papillary Hypertrophy

Hypertrophy Of Foliate Papillae

Smallpox

Variola	Ordinary Smallpox
Alastrim	Amaas

Coumarin Resistance

Warfarin Resistance	Warfarin Sensitivity
Coumadin Sensitivity	Warfarin Response
Poor Metabolism Of Coumarin	Coumarin, Poor Metabolism Of
CMRES

Gilbert Syndrome

Gilbert Disease	Gilbert'S Disease
Gilbert'S Syndrome	Cholemia, Familial
Familial Nonhemolytic Jaundice	Meulengracht Syndrome
Gilbert Syndrome, Susceptibility To	Hyperbilirubinemia, Gilbert Type
Hblrg	Hyperbilirubinemia, Arias Type
Hyperbilirubinemia I	Constitutional Hyperbilirubinemia
Gilbert-Meulengracht Syndrome	Hereditary Nonhemolytic Jaundice
Hyperbilirubinemia Arias Type	Hyperbilirubinemia Type 1
Constitutional Liver Dysfunction	Gilbert-Lereboullet Syndrome
Hyperbilirubinemia 1	Unconjugated Benign Bilirubinemia
GILBS	Gilberts Syndrome
Familial Nonhaemolytic Jaundice	Constitutional Hyperbilirubinaemia
Hereditary Nonhaemolytic Bilirubinaemia	Familial Nonhaemolytic Bilirubinaemia
Idiopathic Hyperbilirubinaemia	Icterus Intermittens Juvenilis
Chronic Intermittent Juvenile Jaundice	Low-Grade Chronic Hyperbilirubinaemia Syndrome
Benign Unconjugated Bilirubinaemia Syndrome	Hereditary Nonhaemolytic Jaundice
Idiopathic Unconjugated Hyperbilirubinaemia	Gilbert--Lereboullet Syndrome
Constitutional Hepatic Dysfunction	Meulengracht Icterus
Cholaemia Familiaris Simplex	Familial Cholaemia
Congenital Familial Cholaemia	Physiologic Cholaemia
Hyperbilirubinaemia Type 1	Gilbert Cholaemia

Bilirubin Metabolic Disorder

Hyperbilirubinemia	Hereditary Hyperbilirubinemia
Hyperbilirubinemia, Hereditary	Hyperbilirubinaemia

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17356	Fenofibrate		99.93%	Yes

Pre-clinical Phase

Bioactive Molecules (35)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-129993	Gemfibrozil 1-O-β-glucuronide	Inhibitor	99.88%	Unkown
HY-N0319	Salvianolic acid C	Inhibitor	99.94%	Unkown
HY-148352	BAY-4931	Antagonist	98.83%	Unkown
HY-135331	N-Desmethyl-Apalutamide		99.68%	Unkown
HY-100641S	4-Hydroxytolbutamide-d9		99.29%	Unkown
HY-114759	MS-PPOH	Inhibitor	99.27%	Unkown
HY-70002AS	N-desmethyl Enzalutamide-d6	Antagonist	97.95%	Unkown
HY-135335S	3'-Hydroxy Repaglinide-d5		99.46%	Unkown
HY-17356R	Fenofibrate (Standard)		99.91%	Unkown
HY-135334	ACP-5862	Inhibitor	98.41%	Unkown
HY-135335	3'-Hydroxy Repaglinide		98.09%	Unkown
HY-135810A	Cletoquine oxalate	Inhibitor	99.76%	Unkown
HY-100641	4-Hydroxytolbutamide		99.69%	Unkown
HY-116862	Dibenzylfluorescein		99.54%	Unkown
HY-163438	BKIDC-1553	Inhibitor	99.65%	Unkown
HY-W754151	N-Desmethyl apalutamide-d4		99.63%	Unkown
HY-135331S	N-Desmethyl-Apalutamide-15N,d4		/	Unkown
HY-135334S	ACP-5862-d4	Inhibitor	/	Unkown
HY-135810	Cletoquine	Inhibitor	/	Unkown
HY-135810S	Cletoquine-d4	Inhibitor	/	Unkown
HY-135810S1	Cletoquine-d4-1	Inhibitor	/	Unkown
HY-155376	mTOR inhibitor-14	Inhibitor	/	Unkown
HY-17356G	Fenofibrate (GMP)		/	Unkown
HY-17356S	Fenofibrate-d6		99.70%	Unkown
HY-17356S1	Fenofibrate-d4		/	Unkown
HY-E70471	Human CYP2C8,High-Reductase		/	Unkown
HY-E70492	Human CYP2C8,Low-Reductase		/	Unkown
HY-E70494	Human CYP2C8,High-Reductase+b5		/	Unkown
HY-E70495	Human CYP2C8,Low-Reductase+b5		/	Unkown
HY-RS03459	CYP2C8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-117160	4-trans-Hydroxy-glibenclamide	Inhibitor	/	Unkown
HY-119311	Ketopioglitazone	Agonist	/	Unkown
HY-124542	5-Hydroxydiclofenac	Inducer	/	Unkown
HY-17356S2	Fenofibrate-13C6		/	Unkown
HY-W587878	Thujopsene		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CYP2C8	RGD	RGD:1308166

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