2. Gene
  3. SYT17 - synaptotagmin 17 Gene

SYT17 - synaptotagmin 17 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Syt-17; sytXVII

Gene ID: 51760 | Gene type: protein coding

About SYT17

This gene has 9 transcripts (splice variants), 160 orthologues and 31 paralogues. Broad expression in brain (RPKM 8.9), prostate (RPKM 3.0) and 15 other tissues.

Summary

Predicted to enable several functions, including calcium ion binding activity; phospholipid binding activity; and syntaxin binding activity. Involved in positive regulation of dendrite extension. Predicted to be located in trans-Golgi network. Predicted to be active in exocytic vesicle and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SYT17 Products(4)

mRNA Protein Name
NM_001308157.2 NP_001295086.1 synaptotagmin-17 isoform 2
NM_001330509.2 NP_001317438.1 synaptotagmin-17 isoform 3
NM_001410903.1 NP_001397832.1 synaptotagmin-17 isoform 4
NM_016524.4 NP_057608.2 synaptotagmin-17 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of dendrite extension IDA
IDA: Inferred from direct assay
23999003 GOA
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: Inferred from direct assay
31387992 GOA
involved in regulation of postsynaptic neurotransmitter receptor internalization IMP
IMP: Inferred from mutant phenotype
31387992 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
31387992 GOA
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
31387992 GOA
is active in postsynapse IDA
IDA: Inferred from direct assay
31387992 GOA
is active in postsynapse IMP
IMP: Inferred from mutant phenotype
31387992 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYT17 Protein Structure

C2

C2: C2 domain (201 - 293)

C2

C2: C2 domain (338 - 425)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 474 a.a.
Protein Preferred Names Protein Names

synaptotagmin-17

B/K protein

SYT17 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra SYT17 Q9BSW7 CCDC102B Homo sapiens Q68D86
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 CCDC102B Homo sapiens Q68D86
Y2H Array
32296183
Intra SYT17 Q9BSW7 FLJ13057 Homo sapiens Q53SE7
Validated Y2H
25416956
Intra SYT17 Q9BSW7 MID2 Homo sapiens Q9UJV3-2
Anti Tag CoIP
28514442
Intra SYT17 Q9BSW7 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra SYT17 Q9BSW7 MID2 Homo sapiens Q9UJV3-2
Y2H Array
25416956
Intra SYT17 Q9BSW7 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
Intra SYT17 Q9BSW7 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
25416956
Intra SYT17 Q9BSW7 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 FAM9B Homo sapiens Q8IZU0
Y2H Array
31515488
Intra SYT17 Q9BSW7 FAM9B Homo sapiens Q8IZU0
Validated Y2H
25416956
Intra SYT17 Q9BSW7 FAM9B Homo sapiens Q8IZU0
Y2H Prey Pooling
25416956
Intra SYT17 Q9BSW7 HOOK2 Homo sapiens Q96ED9-2
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 HOOK2 Homo sapiens Q96ED9-2
Y2H Array
32296183
Intra SYT17 Q9BSW7 GOLGA6A Homo sapiens Q9NYA3
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 GOLGA6A Homo sapiens Q9NYA3
Validated Y2H
32296183
Intra SYT17 Q9BSW7 GOLGA6A Homo sapiens Q9NYA3
Y2H Array
32296183
Intra SYT17 Q9BSW7 CBY2 Homo sapiens Q8NA61-2
Y2H Array
32296183
Intra SYT17 Q9BSW7 CBY2 Homo sapiens Q8NA61-2
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 ZNF438 Homo sapiens Q7Z4V0
Y2H Array
32296183
Intra SYT17 Q9BSW7 ZNF438 Homo sapiens Q7Z4V0
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 POF1B Homo sapiens Q8WVV4-1
Y2H Array
32296183
Intra SYT17 Q9BSW7 POF1B Homo sapiens Q8WVV4-1
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 LZTS1 Homo sapiens Q9Y250
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 LZTS1 Homo sapiens Q9Y250
Validated Y2H
32296183
Intra SYT17 Q9BSW7 LZTS1 Homo sapiens Q9Y250
Y2H Array
32296183
Intra SYT17 Q9BSW7 CHMP4A Homo sapiens Q9BY43-2
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 CHMP4A Homo sapiens Q9BY43-2
Validated Y2H
32296183
Intra SYT17 Q9BSW7 CHMP4A Homo sapiens Q9BY43-2
Y2H Array
32296183
Intra SYT17 Q9BSW7 DEPDC5 Homo sapiens O75140-2
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 DEPDC5 Homo sapiens O75140-2
Y2H Array
32296183
Intra SYT17 Q9BSW7 SNRNP35 Homo sapiens Q16560-2
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 SNRNP35 Homo sapiens Q16560-2
Y2H Array
32296183
Intra SYT17 Q9BSW7 FRMD6 Homo sapiens Q96NE9-2
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 FRMD6 Homo sapiens Q96NE9-2
Y2H Array
32296183
Intra SYT17 Q9BSW7 PIBF1 Homo sapiens Q4G0R1
Y2H Array
32296183
Intra SYT17 Q9BSW7 PIBF1 Homo sapiens Q4G0R1
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra SYT17 Q9BSW7 MAJIN Homo sapiens Q3KP22-3
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 MAJIN Homo sapiens Q3KP22-3
Y2H Array
32296183
Intra SYT17 Q9BSW7 TSNAX Homo sapiens Q99598
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 TSNAX Homo sapiens Q99598
Y2H Array
32296183
Intra SYT17 Q9BSW7 SSX2IP Homo sapiens Q9Y2D8
Validated Y2H
25416956
Intra SYT17 Q9BSW7 SSX2IP Homo sapiens Q9Y2D8
Y2H Prey Pooling
25416956
Intra SYT17 Q9BSW7 SSX2IP Homo sapiens Q9Y2D8
Y2H Array
25416956
Intra SYT17 Q9BSW7 BLZF1 Homo sapiens Q9H2G9
Y2H Array
32296183
Intra SYT17 Q9BSW7 BLZF1 Homo sapiens Q9H2G9
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 BLZF1 Homo sapiens Q9H2G9
Validated Y2H
32296183
Intra SYT17 Q9BSW7 MEOX1 Homo sapiens P50221
Y2H Array
25416956
Intra SYT17 Q9BSW7 MCC Homo sapiens P23508
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 MCC Homo sapiens P23508
Y2H Array
32296183
Intra SYT17 Q9BSW7 LSM7 Homo sapiens Q9UK45
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 LSM7 Homo sapiens Q9UK45
Validated Y2H
32296183
Intra SYT17 Q9BSW7 LSM7 Homo sapiens Q9UK45
Y2H Array
32296183
Intra SYT17 Q9BSW7 TRAF2 Homo sapiens Q12933
Validated Y2H
25416956
Intra SYT17 Q9BSW7 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra SYT17 Q9BSW7 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 COG6 Homo sapiens Q9Y2V7
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 COG6 Homo sapiens Q9Y2V7
Validated Y2H
32296183
Intra SYT17 Q9BSW7 COG6 Homo sapiens Q9Y2V7
Y2H Array
32296183
Intra SYT17 Q9BSW7 HIP1 Homo sapiens O00291
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 HIP1 Homo sapiens O00291
Y2H Array
32296183
Intra SYT17 Q9BSW7 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra SYT17 Q9BSW7 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
Intra SYT17 Q9BSW7 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra SYT17 Q9BSW7 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra SYT17 Q9BSW7 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 CEP70 Homo sapiens Q8NHQ1
Y2H Array
25416956
Intra SYT17 Q9BSW7 NIF3L1 Homo sapiens Q9GZT8
Y2H Array
25416956
Intra SYT17 Q9BSW7 LZTS2 Homo sapiens Q9BRK4
Y2H Array
32296183
Intra SYT17 Q9BSW7 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 CEP63 Homo sapiens Q96MT8
Validated Y2H
25416956
Intra SYT17 Q9BSW7 CEP63 Homo sapiens Q96MT8
Y2H Prey Pooling
25416956
Intra SYT17 Q9BSW7 SDCBP2 Homo sapiens Q9H190
Validated Y2H
32296183
Intra SYT17 Q9BSW7 SDCBP2 Homo sapiens Q9H190
Y2H Array
32296183
Intra SYT17 Q9BSW7 SDCBP2 Homo sapiens Q9H190
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 MAD1L1 Homo sapiens Q9Y6D9
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 MAD1L1 Homo sapiens Q9Y6D9
Validated Y2H
32296183
Intra SYT17 Q9BSW7 MAD1L1 Homo sapiens Q9Y6D9
Y2H Array
32296183
Intra SYT17 Q9BSW7 CCNB1IP1 Homo sapiens Q9NPC3
Validated Y2H
32296183
Intra SYT17 Q9BSW7 CCNB1IP1 Homo sapiens Q9NPC3
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 CCNB1IP1 Homo sapiens Q9NPC3
Y2H Array
32296183
Intra SYT17 Q9BSW7 IKZF1 Homo sapiens Q13422
Validated Y2H
25416956
Intra SYT17 Q9BSW7 RUNDC3A Homo sapiens Q59EK9
Y2H Prey Pooling
25416956
Intra SYT17 Q9BSW7 CHMP4A Homo sapiens Q9BY43
Y2H
16730941
Intra SYT17 Q9BSW7 CHMP4A Homo sapiens Q9BY43
Y2H Array
31515488
Intra SYT17 Q9BSW7 CHMP4A Homo sapiens Q9BY43
Validated Y2H
25416956
Intra SYT17 Q9BSW7 CHMP4A Homo sapiens Q9BY43
Y2H Prey Pooling
25416956
Intra SYT17 Q9BSW7 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
Intra SYT17 Q9BSW7 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra SYT17 Q9BSW7 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra SYT17 Q9BSW7 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 AK8 Homo sapiens Q96MA6
Y2H Array
32296183
Intra SYT17 Q9BSW7 AK8 Homo sapiens Q96MA6
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 VPS9D1 Homo sapiens Q9Y2B5
Validated Y2H
32296183
Intra SYT17 Q9BSW7 VPS9D1 Homo sapiens Q9Y2B5
Y2H Array
32296183
Intra SYT17 Q9BSW7 VPS9D1 Homo sapiens Q9Y2B5
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 ZNF597 Homo sapiens Q96LX8
Y2H Prey Pooling
32296183
Intra SYT17 Q9BSW7 ZNF597 Homo sapiens Q96LX8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2b

Lgmd2b

Lgmd3

Limb-Girdle Muscular Dystrophy Due To Dysferlin Deficiency

Limb-Girdle Muscular Dystrophy Type 3

Muscular Dystrophy, Limb-Girdle, Type 2b
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14113 SYT17 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SYT17 VGNC VGNC:78200
Mus musculus SYT17 MGD MGI:104966
Rattus norvegicus SYT17 RGD RGD:708576
Bos taurus SYT17 VGNC VGNC:35540
Felis catus SYT17 VGNC VGNC:65897