SYT17 - synaptotagmin 17 Gene

Homo sapiens

Also known as Syt-17; sytXVII

Gene ID: 51760 | Gene type: protein coding

About SYT17

This gene has 9 transcripts (splice variants), 160 orthologues and 31 paralogues. Broad expression in brain (RPKM 8.9), prostate (RPKM 3.0) and 15 other tissues.

Summary

Predicted to enable several functions, including calcium ion binding activity; phospholipid binding activity; and syntaxin binding activity. Involved in positive regulation of dendrite extension. Predicted to be located in trans-Golgi network. Predicted to be active in exocytic vesicle and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SYT17 Products(4)

mRNA	Protein	Name
NM_001308157.2	NP_001295086.1	synaptotagmin-17 isoform 2
NM_001330509.2	NP_001317438.1	synaptotagmin-17 isoform 3
NM_001410903.1	NP_001397832.1	synaptotagmin-17 isoform 4
NM_016524.4	NP_057608.2	synaptotagmin-17 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of dendrite extension	IDA IDA: Inferred from direct assay	23999003	GOA
involved in regulation of postsynaptic neurotransmitter receptor internalization	IDA IDA: Inferred from direct assay	31387992	GOA
involved in regulation of postsynaptic neurotransmitter receptor internalization	IMP IMP: Inferred from mutant phenotype	31387992	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	31387992	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	31387992	GOA
is active in postsynapse	IDA IDA: Inferred from direct assay	31387992	GOA
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	31387992	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYT17 Protein Structure

0
100
200
300
400
474 a.a.

Protein Preferred Names

Protein Names

synaptotagmin-17

B/K protein

SYT17 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SYT17	Q9BSW7	CCDC102B	Homo sapiens	Q68D86	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	CCDC102B	Homo sapiens	Q68D86	Y2H Array	32296183
Intra	SYT17	Q9BSW7	FLJ13057	Homo sapiens	Q53SE7	Validated Y2H	25416956
Intra	SYT17	Q9BSW7	MID2	Homo sapiens	Q9UJV3-2	Anti Tag CoIP	28514442
Intra	SYT17	Q9BSW7	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
Intra	SYT17	Q9BSW7	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	25416956
Intra	SYT17	Q9BSW7	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	32296183
Intra	SYT17	Q9BSW7	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	25416956
Intra	SYT17	Q9BSW7	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	31515488
Intra	SYT17	Q9BSW7	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
Intra	SYT17	Q9BSW7	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
Intra	SYT17	Q9BSW7	HOOK2	Homo sapiens	Q96ED9-2	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	HOOK2	Homo sapiens	Q96ED9-2	Y2H Array	32296183
Intra	SYT17	Q9BSW7	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	GOLGA6A	Homo sapiens	Q9NYA3	Validated Y2H	32296183
Intra	SYT17	Q9BSW7	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Array	32296183
Intra	SYT17	Q9BSW7	CBY2	Homo sapiens	Q8NA61-2	Y2H Array	32296183
Intra	SYT17	Q9BSW7	CBY2	Homo sapiens	Q8NA61-2	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	ZNF438	Homo sapiens	Q7Z4V0	Y2H Array	32296183
Intra	SYT17	Q9BSW7	ZNF438	Homo sapiens	Q7Z4V0	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	POF1B	Homo sapiens	Q8WVV4-1	Y2H Array	32296183
Intra	SYT17	Q9BSW7	POF1B	Homo sapiens	Q8WVV4-1	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	LZTS1	Homo sapiens	Q9Y250	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	LZTS1	Homo sapiens	Q9Y250	Validated Y2H	32296183
Intra	SYT17	Q9BSW7	LZTS1	Homo sapiens	Q9Y250	Y2H Array	32296183
Intra	SYT17	Q9BSW7	CHMP4A	Homo sapiens	Q9BY43-2	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	CHMP4A	Homo sapiens	Q9BY43-2	Validated Y2H	32296183
Intra	SYT17	Q9BSW7	CHMP4A	Homo sapiens	Q9BY43-2	Y2H Array	32296183
Intra	SYT17	Q9BSW7	DEPDC5	Homo sapiens	O75140-2	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	DEPDC5	Homo sapiens	O75140-2	Y2H Array	32296183
Intra	SYT17	Q9BSW7	SNRNP35	Homo sapiens	Q16560-2	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	SNRNP35	Homo sapiens	Q16560-2	Y2H Array	32296183
Intra	SYT17	Q9BSW7	FRMD6	Homo sapiens	Q96NE9-2	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	FRMD6	Homo sapiens	Q96NE9-2	Y2H Array	32296183
Intra	SYT17	Q9BSW7	PIBF1	Homo sapiens	Q4G0R1	Y2H Array	32296183
Intra	SYT17	Q9BSW7	PIBF1	Homo sapiens	Q4G0R1	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	SYT17	Q9BSW7	MAJIN	Homo sapiens	Q3KP22-3	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	MAJIN	Homo sapiens	Q3KP22-3	Y2H Array	32296183
Intra	SYT17	Q9BSW7	TSNAX	Homo sapiens	Q99598	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	TSNAX	Homo sapiens	Q99598	Y2H Array	32296183
Intra	SYT17	Q9BSW7	SSX2IP	Homo sapiens	Q9Y2D8	Validated Y2H	25416956
Intra	SYT17	Q9BSW7	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Prey Pooling	25416956
Intra	SYT17	Q9BSW7	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Array	25416956
Intra	SYT17	Q9BSW7	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	32296183
Intra	SYT17	Q9BSW7	BLZF1	Homo sapiens	Q9H2G9	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	BLZF1	Homo sapiens	Q9H2G9	Validated Y2H	32296183
Intra	SYT17	Q9BSW7	MEOX1	Homo sapiens	P50221	Y2H Array	25416956
Intra	SYT17	Q9BSW7	MCC	Homo sapiens	P23508	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	MCC	Homo sapiens	P23508	Y2H Array	32296183
Intra	SYT17	Q9BSW7	LSM7	Homo sapiens	Q9UK45	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	LSM7	Homo sapiens	Q9UK45	Validated Y2H	32296183
Intra	SYT17	Q9BSW7	LSM7	Homo sapiens	Q9UK45	Y2H Array	32296183
Intra	SYT17	Q9BSW7	TRAF2	Homo sapiens	Q12933	Validated Y2H	25416956
Intra	SYT17	Q9BSW7	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	SYT17	Q9BSW7	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	COG6	Homo sapiens	Q9Y2V7	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	COG6	Homo sapiens	Q9Y2V7	Validated Y2H	32296183
Intra	SYT17	Q9BSW7	COG6	Homo sapiens	Q9Y2V7	Y2H Array	32296183
Intra	SYT17	Q9BSW7	HIP1	Homo sapiens	O00291	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	HIP1	Homo sapiens	O00291	Y2H Array	32296183
Intra	SYT17	Q9BSW7	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	SYT17	Q9BSW7	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	SYT17	Q9BSW7	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	SYT17	Q9BSW7	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	SYT17	Q9BSW7	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	25416956
Intra	SYT17	Q9BSW7	NIF3L1	Homo sapiens	Q9GZT8	Y2H Array	25416956
Intra	SYT17	Q9BSW7	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	32296183
Intra	SYT17	Q9BSW7	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	CEP63	Homo sapiens	Q96MT8	Validated Y2H	25416956
Intra	SYT17	Q9BSW7	CEP63	Homo sapiens	Q96MT8	Y2H Prey Pooling	25416956
Intra	SYT17	Q9BSW7	SDCBP2	Homo sapiens	Q9H190	Validated Y2H	32296183
Intra	SYT17	Q9BSW7	SDCBP2	Homo sapiens	Q9H190	Y2H Array	32296183
Intra	SYT17	Q9BSW7	SDCBP2	Homo sapiens	Q9H190	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	MAD1L1	Homo sapiens	Q9Y6D9	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	MAD1L1	Homo sapiens	Q9Y6D9	Validated Y2H	32296183
Intra	SYT17	Q9BSW7	MAD1L1	Homo sapiens	Q9Y6D9	Y2H Array	32296183
Intra	SYT17	Q9BSW7	CCNB1IP1	Homo sapiens	Q9NPC3	Validated Y2H	32296183
Intra	SYT17	Q9BSW7	CCNB1IP1	Homo sapiens	Q9NPC3	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	CCNB1IP1	Homo sapiens	Q9NPC3	Y2H Array	32296183
Intra	SYT17	Q9BSW7	IKZF1	Homo sapiens	Q13422	Validated Y2H	25416956
Intra	SYT17	Q9BSW7	RUNDC3A	Homo sapiens	Q59EK9	Y2H Prey Pooling	25416956
Intra	SYT17	Q9BSW7	CHMP4A	Homo sapiens	Q9BY43	Y2H	16730941
Intra	SYT17	Q9BSW7	CHMP4A	Homo sapiens	Q9BY43	Y2H Array	31515488
Intra	SYT17	Q9BSW7	CHMP4A	Homo sapiens	Q9BY43	Validated Y2H	25416956
Intra	SYT17	Q9BSW7	CHMP4A	Homo sapiens	Q9BY43	Y2H Prey Pooling	25416956
Intra	SYT17	Q9BSW7	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	SYT17	Q9BSW7	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	SYT17	Q9BSW7	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	SYT17	Q9BSW7	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	AK8	Homo sapiens	Q96MA6	Y2H Array	32296183
Intra	SYT17	Q9BSW7	AK8	Homo sapiens	Q96MA6	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	VPS9D1	Homo sapiens	Q9Y2B5	Validated Y2H	32296183
Intra	SYT17	Q9BSW7	VPS9D1	Homo sapiens	Q9Y2B5	Y2H Array	32296183
Intra	SYT17	Q9BSW7	VPS9D1	Homo sapiens	Q9Y2B5	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	ZNF597	Homo sapiens	Q96LX8	Y2H Prey Pooling	32296183
Intra	SYT17	Q9BSW7	ZNF597	Homo sapiens	Q96LX8	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2b

Lgmd2b	Lgmd3
Limb-Girdle Muscular Dystrophy Due To Dysferlin Deficiency	Limb-Girdle Muscular Dystrophy Type 3
Muscular Dystrophy, Limb-Girdle, Type 2b

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14113	SYT17 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SYT17	VGNC	VGNC:78200
Mus musculus	SYT17	MGD	MGI:104966
Rattus norvegicus	SYT17	RGD	RGD:708576
Bos taurus	SYT17	VGNC	VGNC:35540
Felis catus	SYT17	VGNC	VGNC:65897

Name
Email *

	Sorry, but the email address you supplied was invalid.