RBM39 - RNA binding motif protein 39 Gene

Homo sapiens

Also known as HCC1; CAPER; RNPC2; FSAP59; CAPERalpha

Gene ID: 9584 | Gene type: protein coding

About RBM39

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:35,701,347-35,742,260 (from NCBI)

This gene has 47 transcripts (splice variants), 279 orthologues and 36 paralogues. Ubiquitous expression in bone marrow (RPKM 103.4), lymph node (RPKM 47.1) and 25 other tissues.

Summary

This gene encodes a member of the U2AF65 family of proteins. The encoded protein is found in the nucleus, where it co-localizes with core spliceosomal proteins. It has been shown to play a role in both steroid hormone receptor-mediated transcription and alternative splicing, and it is also a transcriptional coregulator of the viral oncoprotein v-Rel. Multiple transcript variants have been observed for this gene. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Aug 2011]

RBM39 Products(7)

mRNA	Protein	Name
NM_001242599.2	NP_001229528.1	RNA-binding protein 39 isoform c
NM_001242600.2	NP_001229529.1	RNA-binding protein 39 isoform d
NM_001323422.2	NP_001310351.1	RNA-binding protein 39 isoform e
NM_001323423.2	NP_001310352.1	RNA-binding protein 39 isoform f
NM_001323424.2	NP_001310353.1	RNA-binding protein 39 isoform g
NM_004902.4	NP_004893.1	RNA-binding protein 39 isoform b
NM_184234.3	NP_909122.1	RNA-binding protein 39 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15798186	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	15694343	GOA
involved in regulation of mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	28302793	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear speck	IMP IMP: Inferred from mutant phenotype	28437394	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	28437394	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM39 Protein Structure

RRM_1

RBM39linker

RRM_5

0
100
200
300
400
500
530 a.a.

Protein Preferred Names

Protein Names

RNA-binding protein 39

CAPER alpha

RBM39 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RBM39	Q14498	KRTAP12-2	Homo sapiens	P59991	Y2H Prey Pooling	25416956
Intra	RBM39	Q14498	KRTAP12-2	Homo sapiens	P59991	Y2H Array	25416956
Intra	RBM39	Q14498	KRTAP12-2	Homo sapiens	P59991	Validated Y2H	25416956
Intra	RBM39	Q14498	NKAPD1	Homo sapiens	Q6ZUT1-2	Y2H Prey Pooling	25416956
Intra	RBM39	Q14498	ARL6IP4	Homo sapiens	Q66PJ3-3	Validated Y2H	25416956
Intra	RBM39	Q14498	ARL6IP4	Homo sapiens	Q66PJ3-3	Y2H Array	25416956
Intra	RBM39	Q14498	SREK1IP1	Homo sapiens	Q8N9Q2	Validated Y2H	25416956
Intra	RBM39	Q14498	SAP18	Homo sapiens	O00422	Validated Y2H	25416956
Intra	RBM39	Q14498	SAP18	Homo sapiens	O00422	Y2H Prey Pooling	32296183
Intra	RBM39	Q14498	SAP18	Homo sapiens	O00422	Y2H Array	32296183
Intra	RBM39	Q14498	SAP18	Homo sapiens	O00422	Anti Tag CoIP	35271311
Intra	RBM39	Q14498	SREK1	Homo sapiens	Q8WXA9	Validated Y2H	32296183
Intra	RBM39	Q14498	SREK1	Homo sapiens	Q8WXA9	Y2H Array	32296183
Intra	RBM39	Q14498	SREK1	Homo sapiens	Q8WXA9	Y2H Prey Pooling	32296183
Intra	RBM39	Q14498	SRSF11	Homo sapiens	Q05519	Validated Y2H	25416956
Intra	RBM39	Q14498	SRSF11	Homo sapiens	Q05519	Y2H Prey Pooling	25416956
Intra	RBM39	Q14498	SRSF11	Homo sapiens	Q05519-2	Y2H Array	32296183
Intra	RBM39	Q14498	SRSF11	Homo sapiens	Q05519-2	Y2H Prey Pooling	32296183
Intra	RBM39	Q14498	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	RBM39	Q14498	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	RBM39	Q14498	CSNK2A1	Homo sapiens	P68400	Y2H Prey Pooling	32296183
Intra	RBM39	Q14498	CSNK2A1	Homo sapiens	P68400	Y2H Array	32296183
Intra	RBM39	Q14498	CSNK2B	Homo sapiens	P67870	Y2H Prey Pooling	32296183
Intra	RBM39	Q14498	CSNK2B	Homo sapiens	P67870	Y2H Array	32296183
Intra	RBM39	Q14498	CSNK2B	Homo sapiens	P67870	Anti Tag CoIP	35271311
Intra	RBM39	Q14498	SF3B4	Homo sapiens	Q15427	Anti Tag CoIP	35271311
Intra	RBM39	Q14498	SRRM4	Homo sapiens	A7MD48	Y2H Prey Pooling	32296183
Intra	RBM39	Q14498	SRRM4	Homo sapiens	A7MD48	Y2H Array	32296183
Intra	RBM39	Q14498	NKAPD1	Homo sapiens	Q6ZUT1	Y2H Prey Pooling	25416956
Intra	RBM39	Q14498	NKAPD1	Homo sapiens	Q6ZUT1	Validated Y2H	25416956
Intra	RBM39	Q14498	NKAPD1	Homo sapiens	Q6ZUT1	Y2H Prey Pooling	32296183
Intra	RBM39	Q14498	NKAPD1	Homo sapiens	Q6ZUT1	Validated Y2H	32296183
Intra	RBM39	Q14498	NKAPD1	Homo sapiens	Q6ZUT1	Y2H Array	32296183
Intra	RBM39	Q14498	PPIG	Homo sapiens	Q13427	Y2H Prey Pooling	25416956
Intra	RBM39	Q14498	PPIG	Homo sapiens	Q13427	Anti Tag CoIP	35271311
Intra	RBM39	Q14498	PPIG	Homo sapiens	Q13427	Y2H Array	25416956
Intra	RBM39	Q14498	PRPF40A	Homo sapiens	O75400-2	Y2H Prey Pooling	25416956
Intra	RBM39	Q14498	SRPK1	Homo sapiens	Q96SB4	Protein Kinase Assay	23602568
Intra	RBM39	Q14498	SRPK1	Homo sapiens	Q96SB4	Anti Tag CoIP	35271311
Intra	RBM39	Q14498	SRPK2	Homo sapiens	P78362	BiFC	23602568
Intra	RBM39	Q14498	SRPK2	Homo sapiens	P78362	Y2H	22365833
Intra	RBM39	Q14498	SRPK2	Homo sapiens	P78362	Y2H Prey Pooling	25416956
Intra	RBM39	Q14498	SRPK2	Homo sapiens	P78362	Y2H Array	25416956
Intra	RBM39	Q14498	SRPK2	Homo sapiens	P78362	Anti Tag CoIP	35271311
Intra	RBM39	Q14498	ZCCHC10	Homo sapiens	Q8TBK6	Validated Y2H	25416956
Intra	RBM39	Q14498	ZCCHC10	Homo sapiens	Q8TBK6	Y2H	22365833
Intra	RBM39	Q14498	ZCCHC10	Homo sapiens	Q8TBK6	Y2H Prey Pooling	25416956
Intra	RBM39	Q14498	PHC2	Homo sapiens	Q8IXK0	Y2H Array	25416956
Intra	RBM39	Q14498	INO80B	Homo sapiens	Q9C086	Validated Y2H	32296183
Intra	RBM39	Q14498	SDCBP	Homo sapiens	O00560	Y2H Array	25416956
Intra	RBM39	Q14498	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
Intra	RBM39	Q14498	DVL3	Homo sapiens	Q92997	Y2H Array	32296183
Intra	RBM39	Q14498	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	32296183
Intra	RBM39	Q14498	DVL3	Homo sapiens	Q92997	Validated Y2H	32296183
Intra	RBM39	Q14498	THAP1	Homo sapiens	Q9NVV9	Y2H Prey Pooling	25416956
Intra	RBM39	Q14498	THAP1	Homo sapiens	Q9NVV9	Y2H Prey Pooling	32296183
Intra	RBM39	Q14498	THAP1	Homo sapiens	Q9NVV9	Validated Y2H	25416956
Intra	RBM39	Q14498	THAP1	Homo sapiens	Q9NVV9	Validated Y2H	32296183
Intra	RBM39	Q14498	THAP1	Homo sapiens	Q9NVV9	Y2H Array	32296183
Intra	RBM39	Q14498	CLK2	Homo sapiens	P49760	Y2H Prey Pooling	25416956
Intra	RBM39	Q14498	CLK2	Homo sapiens	P49760	Validated Y2H	25416956
Intra	RBM39	Q14498	CLK2	Homo sapiens	P49760	Y2H Prey Pooling	32296183
Intra	RBM39	Q14498	CLK2	Homo sapiens	P49760	Y2H Array	25416956
Intra	RBM39	Q14498	CLK2	Homo sapiens	P49760	Y2H Array	32296183
Intra	RBM39	Q14498	KHDC4	Homo sapiens	Q7Z7F0	Validated Y2H	25416956
Intra	RBM39	Q14498	KHDC4	Homo sapiens	Q7Z7F0	Y2H Prey Pooling	25416956
Intra	RBM39	Q14498	KHDC4	Homo sapiens	Q7Z7F0	Y2H Array	25416956
Intra	RBM39	Q14498	AK8	Homo sapiens	Q96MA6	Validated Y2H	25416956
Intra	RBM39	Q14498	PCBP1	Homo sapiens	Q15365	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13650	Indisulam	Inhibitor	99.80%	Phase 2

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W133627	dCeMM1		99.53%	Unkown
HY-RS11751	RBM39 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RBM39	RGD	RGD:1310071
Mus musculus	RBM39	MGD	MGI:2157953
Canis familiaris	RBM39	VGNC	VGNC:45420
Macaca mulatta	RBM39	VGNC	VGNC:98434
Felis catus	RBM39	VGNC	VGNC:64529
Bos taurus	RBM39	VGNC	VGNC:33799

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