Igf1r - insulin-like growth factor I receptor Gene

Mus musculus

Also known as hyft; CD221; IGF-1R; D930020L01; A330103N21Rik

Gene ID: 16001 | Gene type: protein coding

About Igf1r

Chromosome 7: 67,602,575-67,883,416 forward strand.GRCm39:CM001000.3

This gene has 6 transcripts (splice variants), 276 orthologues, 53 paralogues and is associated with 37 phenotypes. Ubiquitous expression in limb E14.5 (RPKM 1.6), kidney adult (RPKM 1.1) and 27 other tissues.

Summary

Enables insulin-like growth factor binding activity. Involved in several processes, including adrenal gland development; positive regulation of cold-induced thermogenesis; and positive regulation of meiotic cell cycle. Acts upstream of or within several processes, including gland development; peptidyl-tyrosine autophosphorylation; and regulation of intracellular signal transduction. Located in T-tubule. Is integral component of membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and lung. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); kidney Cancer (multiple); liver disease (multiple); nervous system Cancer (multiple); and neurodegenerative disease (multiple). Orthologous to human IGF1R (Insulin like growth factor 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Igf1r Products(1)

mRNA	Protein	Name
NM_010513.3	NP_034643.2	insulin-like growth factor 1 receptor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables insulin-like growth factor binding	IPI IPI: Inferred from physical interaction	14566968	MGI
enables insulin-like growth factor receptor activity	IDA IDA: Inferred from direct assay	19302825	MGI
enables insulin-like growth factor receptor activity	IGI IGI: Inferred from genetic interaction	33567274	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12771153	MGI
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	7799946	MGI
enables protein tyrosine kinase activity	IGI IGI: Inferred from genetic interaction	9024787	MGI
enables protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	12483226	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of MAPK cascade	IMP IMP: Inferred from mutant phenotype	18451178	MGI
involved in adrenal gland development	IGI IGI: Inferred from genetic interaction	23300479	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	12101187	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	12904469	MGI
acts upstream of or within cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	21677284	MGI
acts upstream of or within cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	21677284	MGI
acts upstream of or within epidermis development	IMP IMP: Inferred from mutant phenotype	23906066	MGI
acts upstream of or within exocrine pancreas development	IMP IMP: Inferred from mutant phenotype	12101187	MGI
involved in insulin-like growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	29348399	MGI
involved in insulin-like growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	8402901	MGI
involved in insulin-like growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12483226	MGI
acts upstream of or within male sex determination	IMP IMP: Inferred from mutant phenotype	14628051	MGI
acts upstream of or within mammary gland development	IMP IMP: Inferred from mutant phenotype	17662267	MGI
acts upstream of mitotic nuclear division	IMP IMP: Inferred from mutant phenotype	23906066	MGI
acts upstream of or within negative regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	23906066	MGI
acts upstream of or within negative regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	18451178	MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	18451178	MGI
acts upstream of or within peptidyl-tyrosine autophosphorylation	IDA IDA: Inferred from direct assay	10100151	MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	18451178	MGI
involved in positive regulation of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	23300479	MGI
acts upstream of or within positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	18451178	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	26910308	MGI
involved in positive regulation of developmental growth	IMP IMP: Inferred from mutant phenotype	23300479	MGI
involved in positive regulation of meiotic cell cycle	IGI IGI: Inferred from genetic interaction	23300479	MGI
acts upstream of or within positive regulation of mitotic nuclear division	IMP IMP: Inferred from mutant phenotype	23906066	MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	18451178	MGI
involved in postsynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	28683263	MGI
involved in postsynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	28683263	MGI
acts upstream of or within prostate gland epithelium morphogenesis	IMP IMP: Inferred from mutant phenotype	18451178	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	18216249	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in T-tubule	IDA IDA: Inferred from direct assay	23695157	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	28683263	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	28683263	MGI
located in membrane	IDA IDA: Inferred from direct assay	7931420	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	18451178	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Igf1r Protein Structure

Recep_L_domain

Furin-like

Recep_L_domain

FN3

PTKc_InsR_like

0
300
600
900
1200
1369 a.a.

Protein Preferred Names

Protein Names

insulin-like growth factor 1 receptor

IGF-I receptor

line 186

Recombinant Igf1r Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78723	IGF-I R Protein, Mouse (HEK293, His)	Q60751-1 (E31-H936)	≥95%

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15656	Ceritinib	Inhibitor	99.98%	Yes
HY-15656A	Ceritinib dihydrochloride	Inhibitor	99.57%	Yes
HY-B0025	Voglibose	Inhibitor	≥98.0%	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99165	Teprotumumab	Inhibitor	99.46%	Unkown

Clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15494	Picropodophyllin		99.85%	Phase 2
HY-10200	BMS-754807	Inhibitor	99.41%	Phase 2
HY-15749	XL228	Inhibitor	99.64%	Phase 1
HY-B0794B	AZ7550 Mesylate	Inhibitor	99.24%	Phase 1
HY-13326	ASP3026		99.88%	Phase 1
HY-B0794	AZ7550	Inhibitor	/	Phase 1
HY-B0794A	AZ7550 hydrochloride	Inhibitor	98.66%	Phase 1

Inhibitory Antibodies (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99294	Ganitumab	Inhibitor	96.00%	Phase 3
HY-P99197	Figitumumab	Inhibitor	96.89%	Phase 3
HY-P99284	Dalotuzumab		97.43%	Phase 2
HY-P99218	Robatumumab	Inhibitor	/	Phase 2
HY-P99712	Lonigutamab	Inhibitor	95.00%	Phase 2
HY-P99672	Istiratumab	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (30)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-116624	MAZ51		99.96%	Unkown
HY-10262	BMS-536924		99.83%	Unkown
HY-50866	NVP-AEW541		99.92%	Unkown
HY-15609	AZD-3463		99.58%	Unkown
HY-10252	NVP-ADW742		99.54%	Unkown
HY-N0908	Ginsenoside Rg5		99.87%	Unkown
HY-10524	GSK1904529A		99.66%	Unkown
HY-10253	AG1024		99.82%	Unkown
HY-13203	NVP-TAE 226		99.77%	Unkown
HY-100349	SU4312	Inhibitor	99.76%	Unkown
HY-18785	Indirubin Derivative E804	Inhibitor	98.54%	Unkown
HY-135680	I-OMe-Tyrphostin AG 538	Inhibitor	98.03%	Unkown
HY-145110	IGF-1R inhibitor-2	Inhibitor	98.36%	Unkown
HY-125102	AZ12253801	Inhibitor	/	Unkown
HY-50866B	NVP-AEW541 dihydrochloride		/	Unkown
HY-108230	ALK-IN-12	Inhibitor	/	Unkown
HY-15494S1	Picropodophyllin-d6		/	Unkown
HY-156914	IGF-1R/SRC-IN-1	Inhibitor	99.86%	Unkown
HY-162506	IGF-1R inhibitor-3	Inhibitor	/	Unkown
HY-167854	KW-2450 free base		/	Unkown
HY-402309	IGF-1R modulator 1	Modulator	/	Unkown
HY-B0794S	AZ7550-d5	Inhibitor	/	Unkown
HY-RS06615	IGF1R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06616	Igf1r Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06617	Igf1r Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-100349A	cis-SU4312	Inhibitor	/	Unkown
HY-14357	BMS 695735	Inhibitor	/	Unkown
HY-168616	CL-A3-7	Inhibitor	/	Unkown
HY-21291	SU-4313	Modulator	/	Unkown
HY-N6611	Chimaphilin	Inhibitor	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990084	Veligrotug	Inhibitor	99.25%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Igf1r	NCBI	NCBI:3480
Macaca fascicularis	Igf1r	NCBI	NCBI:102130142
Rattus norvegicus	Igf1r	NCBI	NCBI:25718

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