Igf1r - insulin-like growth factor 1 receptor Gene

Rattus norvegicus

Also known as Igfr1; JTK13; IGFIRC; IGF-1 receptor

Gene ID: 25718 | Gene type: protein coding

About Igf1r

Primary_assembly 1: 121,550,743-121,831,777 forward strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 276 orthologues, 54 paralogues and is associated with 88 phenotypes. Biased expression in Adrenal (RPKM 154.5), Kidney (RPKM 119.) and 9 other tissues.

Summary

Enables G-protein alpha-subunit binding activity; Insulin Receptor substrate binding activity; and insulin-like growth factor-activated receptor activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of apoptotic process; and nervous system development. Located in several cellular components, including T-tubule; caveola; and neuronal cell body. Used to study Alzheimer's disease; Parkinson's disease; and prostate adenocarcinoma. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); cryptorchidism; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney Cancer (multiple); liver disease (multiple); and nervous system Cancer (multiple). Orthologous to human IGF1R (Insulin like growth factor 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Igf1r Products(2)

mRNA	Protein	Name
NM_001414181.1	NP_001401110.1	insulin-like growth factor 1 receptor isoform 1 precursor
NM_052807.3	NP_434694.1	insulin-like growth factor 1 receptor isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G-protein alpha-subunit binding	IPI IPI: Inferred from physical interaction	19764351	RGD
enables insulin receptor substrate binding	IPI IPI: Inferred from physical interaction	15272025	RGD
enables insulin-like growth factor receptor activity	IDA IDA: Inferred from direct assay	16909201	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11423532	RGD
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	16909201	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	15272025	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in axonogenesis	IMP IMP: Inferred from mutant phenotype	16845384	RGD
involved in cardiac atrium development	IEP IEP: Inferred from expression pattern	15486038	RGD
involved in cellular response to aldosterone	IEP IEP: Inferred from expression pattern	22173225	RGD
involved in cellular response to angiotensin	IEP IEP: Inferred from expression pattern	8579617	RGD
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	19853640	RGD
involved in cellular response to estradiol stimulus	IEP IEP: Inferred from expression pattern	10650946	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	20633551	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	20013160	RGD
involved in cellular response to insulin-like growth factor stimulus	IEP IEP: Inferred from expression pattern	23349896	RGD
involved in cellular response to insulin-like growth factor stimulus	IPI IPI: Inferred from physical interaction	12837295	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	21854769	RGD
involved in cellular response to progesterone stimulus	IEP IEP: Inferred from expression pattern	19853640	RGD
involved in cellular response to testosterone stimulus	IEP IEP: Inferred from expression pattern	10650946	RGD
involved in cellular response to transforming growth factor beta stimulus	IPI IPI: Inferred from physical interaction	12837295	RGD
involved in cellular response to zinc ion starvation	IEP IEP: Inferred from expression pattern	21893222	RGD
involved in cellular senescence	IEP IEP: Inferred from expression pattern	19862643	RGD
involved in cerebellum development	IEP IEP: Inferred from expression pattern	23397157	RGD
involved in cerebellum development	IMP IMP: Inferred from mutant phenotype	21443795	RGD
involved in dendritic spine maintenance	IGI IGI: Inferred from genetic interaction	19406747	RGD
involved in establishment of cell polarity	IMP IMP: Inferred from mutant phenotype	16845384	RGD
involved in estrous cycle	IMP IMP: Inferred from mutant phenotype	17567960	RGD
involved in hippocampus development	IEP IEP: Inferred from expression pattern	22042446	RGD
involved in insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19406747	RGD
involved in negative regulation of cholangiocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	17531559	RGD
involved in negative regulation of hepatocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	17531559	RGD
involved in negative regulation of muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	19507001	RGD
involved in neuron projection development	IDA IDA: Inferred from direct assay	15567343	RGD
involved in positive regulation of DNA metabolic process	IMP IMP: Inferred from mutant phenotype	19507001	RGD
involved in positive regulation of axon regeneration	IMP IMP: Inferred from mutant phenotype	23349896	RGD
involved in positive regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	19507001	RGD
involved in positive regulation of osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	15110779	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	25186839	RGD
involved in positive regulation of protein-containing complex disassembly	IGI IGI: Inferred from genetic interaction	19406747	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	21854769	RGD
involved in positive regulation of steroid hormone biosynthetic process	IMP IMP: Inferred from mutant phenotype	17023532	RGD
involved in response to L-glutamate	IDA IDA: Inferred from direct assay	18981172	RGD
involved in response to alkaloid	IEP IEP: Inferred from expression pattern	30240970	RGD
involved in response to ethanol	IDA IDA: Inferred from direct assay	17645580	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	24239160	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	30240970	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	19008912	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	22265867	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	21266509	RGD
involved in response to vitamin E	IEP IEP: Inferred from expression pattern	17447016	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in T-tubule	IDA IDA: Inferred from direct assay	23118311	RGD
located in axon	IDA IDA: Inferred from direct assay	23349896	RGD
located in caveola	IDA IDA: Inferred from direct assay	18022157	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	19862643	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Igf1r Protein Structure

Recep_L_domain

Furin-like

Recep_L_domain

FN3

PTKc_InsR_like

0
300
600
900
1200
1372 a.a.

Protein Preferred Names

Protein Names

insulin-like growth factor 1 receptor

IGF-I receptor	insulin-like growth factor I receptor
type-I IGF receptor

Recombinant Igf1r Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78724	IGF-I R Protein, Rat (HEK293, His)	P24062 (E31-H936)	≥95%

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15656	Ceritinib	Inhibitor	99.98%	Yes
HY-15656A	Ceritinib dihydrochloride	Inhibitor	99.57%	Yes
HY-B0025	Voglibose	Inhibitor	≥98.0%	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99165	Teprotumumab	Inhibitor	99.46%	Unkown

Clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15494	Picropodophyllin		99.85%	Phase 2
HY-10200	BMS-754807	Inhibitor	99.41%	Phase 2
HY-15749	XL228	Inhibitor	99.64%	Phase 1
HY-B0794B	AZ7550 Mesylate	Inhibitor	99.24%	Phase 1
HY-13326	ASP3026		99.88%	Phase 1
HY-B0794	AZ7550	Inhibitor	/	Phase 1
HY-B0794A	AZ7550 hydrochloride	Inhibitor	98.66%	Phase 1

Inhibitory Antibodies (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99294	Ganitumab	Inhibitor	96.00%	Phase 3
HY-P99197	Figitumumab	Inhibitor	96.89%	Phase 3
HY-P99284	Dalotuzumab		97.43%	Phase 2
HY-P99218	Robatumumab	Inhibitor	/	Phase 2
HY-P99712	Lonigutamab	Inhibitor	95.00%	Phase 2
HY-P99672	Istiratumab	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (30)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-116624	MAZ51		99.96%	Unkown
HY-10262	BMS-536924		99.83%	Unkown
HY-50866	NVP-AEW541		99.92%	Unkown
HY-15609	AZD-3463		99.58%	Unkown
HY-10252	NVP-ADW742		99.54%	Unkown
HY-N0908	Ginsenoside Rg5		99.87%	Unkown
HY-10524	GSK1904529A		99.66%	Unkown
HY-10253	AG1024		99.82%	Unkown
HY-13203	NVP-TAE 226		99.77%	Unkown
HY-100349	SU4312	Inhibitor	99.76%	Unkown
HY-18785	Indirubin Derivative E804	Inhibitor	98.54%	Unkown
HY-135680	I-OMe-Tyrphostin AG 538	Inhibitor	98.03%	Unkown
HY-145110	IGF-1R inhibitor-2	Inhibitor	98.36%	Unkown
HY-125102	AZ12253801	Inhibitor	/	Unkown
HY-50866B	NVP-AEW541 dihydrochloride		/	Unkown
HY-108230	ALK-IN-12	Inhibitor	/	Unkown
HY-15494S1	Picropodophyllin-d6		/	Unkown
HY-156914	IGF-1R/SRC-IN-1	Inhibitor	99.86%	Unkown
HY-162506	IGF-1R inhibitor-3	Inhibitor	/	Unkown
HY-167854	KW-2450 free base		/	Unkown
HY-402309	IGF-1R modulator 1	Modulator	/	Unkown
HY-B0794S	AZ7550-d5	Inhibitor	/	Unkown
HY-RS06615	IGF1R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06616	Igf1r Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06617	Igf1r Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-100349A	cis-SU4312	Inhibitor	/	Unkown
HY-14357	BMS 695735	Inhibitor	/	Unkown
HY-168616	CL-A3-7	Inhibitor	/	Unkown
HY-21291	SU-4313	Modulator	/	Unkown
HY-N6611	Chimaphilin	Inhibitor	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990084	Veligrotug	Inhibitor	99.25%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Igf1r	NCBI	NCBI:3480
Macaca fascicularis	Igf1r	NCBI	NCBI:102130142
Mus musculus	Igf1r	NCBI	NCBI:16001

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