Mif - macrophage migration inhibitory factor (glycosylation-inhibiting factor) Gene

Mus musculus

Also known as GIF; DER6; Glif

Gene ID: 17319 | Gene type: protein coding

About Mif

Summary

Enables cytokine activity; phenylpyruvate tautomerase activity; and protease binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within DNA damage response, signal transduction by p53 class mediator; cell aging; and regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in allergic disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Orthologous to human MIF (macrophage migration inhibitory factor). [provided by Alliance of Genome Resources, Apr 2022]

Mif Products(1)

mRNA	Protein	Name
NM_010798.3	NP_034928.1	macrophage migration inhibitory factor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	10364264	MGI
enables phenylpyruvate tautomerase activity	IMP IMP: Inferred from mutant phenotype	16285950	MGI
enables protease binding	IPI IPI: Inferred from physical interaction	21817065	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA damage response, signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	12878730	MGI
acts upstream of or within cellular senescence	IMP IMP: Inferred from mutant phenotype	12878730	MGI
involved in negative regulation of DNA damage response, signal transduction by p53 class mediator	IDA IDA: Inferred from direct assay	17045821	MGI
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	17045821	MGI
involved in negative regulation of mature B cell apoptotic process	IDA IDA: Inferred from direct assay	18056708	MGI
involved in negative regulation of myeloid cell apoptotic process	IMP IMP: Inferred from mutant phenotype	11756671	MGI
involved in negative regulation of protein metabolic process	IDA IDA: Inferred from direct assay	11756671	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	10364264	MGI
involved in positive regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	10364264	MGI
involved in positive regulation of arachidonate secretion	IDA IDA: Inferred from direct assay	10364264	MGI
involved in positive regulation of chemokine (C-X-C motif) ligand 2 production	IDA IDA: Inferred from direct assay	18056708	MGI
involved in positive regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	10364264	MGI
involved in positive regulation of lipopolysaccharide-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	11756671	MGI
involved in positive regulation of myeloid leukocyte cytokine production involved in immune response	IMP IMP: Inferred from mutant phenotype	11756671	MGI
involved in positive regulation of prostaglandin secretion involved in immune response	IMP IMP: Inferred from mutant phenotype	11756671	MGI
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	10364264	MGI
acts upstream of or within regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12878730	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	11756671	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

macrophage migration inhibitory factor

L-dopachrome isomerase	L-dopachrome tautomerase
delayed early response protein 6	phenylpyruvate tautomerase

Recombinant Mif Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7388	MIF Protein, Mouse	P34884 (M1-A115)	≥95%
HY-P70341	MIF Protein, Mouse (His)	P34884 (P2-A115)	≥95%
HY-P70341AF	Animal-Free MIF Protein, Mouse (His)	P34884 (M1-A115)	≥95%
HY-P700517	MIF Protein, Mouse (P. pastoris, His)	P34884 (P2-A115)	≥95%

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17009	Iguratimod	Inhibitor	99.93%	Yes

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16692	ISO-1	Inhibitor	99.94%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99262	Imalumab	Inhibitor	98.37%	Phase 2

Pre-clinical Phase

Bioactive Molecules (27)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110063	4-IPP	Inhibitor	99.46%	Unkown
HY-110095	(±)-CPSI-1306	Antagonist	98.90%	Unkown
HY-147390	MIF098	Inhibitor	99.88%	Unkown
HY-105077A	Nemifitide diTFA		98.01%	Unkown
HY-115887	R110	Inhibitor	99.90%	Unkown
HY-123814	4-CPPC	Inhibitor	99.64%	Unkown
HY-107663A	MIF-1 TFA	Modulator	99.25%	Unkown
HY-110084	BTZO-1		99.69%	Unkown
HY-N10096	Epoxyazadiradione		99.21%	Unkown
HY-W019710	(E,E)-RGFP966	Inhibitor	99.31%	Unkown
HY-W164560	RDR 03785	Inhibitor	96.24%	Unkown
HY-130332	Mitomycin A	Inhibitor	97.3%	Unkown
HY-148117	MD13	Inhibitor	/	Unkown
HY-D0039	3-Cyanoumbelliferone		≥98.0%	Unkown
HY-149308	MKA031	Inhibitor	/	Unkown
HY-107663	MIF-1	Modulator	/	Unkown
HY-115888	MIF2-IN-1	Inhibitor	/	Unkown
HY-144190	MIF-IN-1	Inhibitor	/	Unkown
HY-144194	MIF-IN-2	Inhibitor	/	Unkown
HY-144195	MIF-IN-3	Inhibitor	/	Unkown
HY-144196	MIF-IN-4 hydrochloride	Inhibitor	/	Unkown
HY-146318	MIF-IN-5	Inhibitor	/	Unkown
HY-146319	MIF-IN-6	Inhibitor	/	Unkown
HY-155466	Boc-MIF-1-Am	Activator	/	Unkown
HY-P3087	Tyr-W-MIF-1	Modulator	/	Unkown
HY-RS08445	MIF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-U00271	Pareptide monohydrochloride		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mif	NCBI	NCBI:4282

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