Comt - catechol-O-methyltransferase Gene

Rattus norvegicus

Gene ID: 24267 | Gene type: protein coding

About Comt

Primary_assembly 11: 82,568,025-82,587,642 forward strand.mRatBN7.2:CM026984.1

This gene has 3 transcripts (splice variants), 276 orthologues, 2 paralogues and is associated with 68 phenotypes. Biased expression in Liver (RPKM 255.1), Kidney (RPKM 1227.4) and 5 other tissues.

Summary

Enables catechol O-methyltransferase activity. Involved in several processes, including learning or memory; negative regulation of smooth muscle cell proliferation; and regulation of cellular amine metabolic process. Located in several cellular components, including cell body; dendritic spine; and postsynaptic membrane. Used to study Parkinsonism and hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autoimmune disease of skin and connective tissue (multiple); bulimia nervosa; cognitive disorder (multiple); and reproductive organ Cancer (multiple). Orthologous to human COMT (catechol-O-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Comt Products(1)

mRNA	Protein	Name
NM_012531.2	NP_036663.1	catechol O-methyltransferase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables catechol O-methyltransferase activity	IDA IDA: Inferred from direct assay	12584150	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in estrogen metabolic process	IMP IMP: Inferred from mutant phenotype	11071850	RGD
involved in female pregnancy	IMP IMP: Inferred from mutant phenotype	18042640	RGD
involved in learning	IMP IMP: Inferred from mutant phenotype	15190105	RGD
involved in negative regulation of dopamine metabolic process	IMP IMP: Inferred from mutant phenotype	15190105	RGD
involved in negative regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	11071850	RGD
involved in positive regulation of homocysteine metabolic process	IMP IMP: Inferred from mutant phenotype	15779086	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	22100850	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	17573159	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	15964593	RGD
involved in response to pain	IMP IMP: Inferred from mutant phenotype	17084978	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	17868501	RGD
involved in short-term memory	IMP IMP: Inferred from mutant phenotype	22815336	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	21846718	RGD
located in cell body	IDA IDA: Inferred from direct assay	21846718	RGD
located in dendrite	IDA IDA: Inferred from direct assay	21846718	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	7617303	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	7617303	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	7617303	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	7617303	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Comt Protein Structure

YrrM

0
100
200
265 a.a.

Protein Preferred Names

Protein Names

catechol O-methyltransferase

catecholamine-O-methyltransferase

Related Agents

Approval

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1473	Serotonin hydrochloride	Inhibitor	99.97%	Unkown
HY-B1473A	Serotonin	Inhibitor	99.86%	Unkown
HY-17406	Tolcapone	Inhibitor	99.91%	Yes
HY-14280	Entacapone	Inhibitor	99.97%	Yes
HY-14896	Opicapone	Inhibitor	99.06%	Yes
HY-100562	Flopropione	Inhibitor	98.57%	Unkown
HY-14280R	Entacapone (Standard)	Inhibitor	/	Unkown
HY-17406R	Tolcapone (Standard)	Inhibitor	/	Unkown
HY-14280A	Entacapone sodium salt	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N0529	Rosmarinic acid	Inhibitor	99.73%	Phase 4
HY-106405	Nebicapone	Inhibitor	99.89%	Phase 2
HY-106842	Nitecapone	Inhibitor	99.53%	Phase 2
HY-19061	CGP 28014	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (26)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0522	(-)-Gallocatechin gallate	Inhibitor	99.97%	Unkown
HY-B1473AS	Serotonin-d4	Inhibitor	99.60%	Unkown
HY-B1473S	Serotonin-d4 hydrochloride	Inhibitor	/	Unkown
HY-151388	hMAO-B/MB-COMT-IN-1	Inhibitor	98.04%	Unkown
HY-133068	5-Hydroxyferulic acid		99.80%	Unkown
HY-128410	4-Phenyl-7,8-dihydroxycoumarin	Inhibitor	99.35%	Unkown
HY-100959	3,5-Dinitrocatechol	Inhibitor	99.72%	Unkown
HY-125339	Ro 41-0960	Inhibitor	≥98.0%	Unkown
HY-17406S1	Tolcapone-d4	Inhibitor	99.13%	Unkown
HY-14280S	Entacapone-d10	Inhibitor	≥98.0%	Unkown
HY-121949	U-0521	Inhibitor	98.67%	Unkown
HY-W012264	3-O-Methyldopa monohydrate		98.87%	Unkown
HY-157719	S-Adenosylhomocysteine sulfoxide	Inhibitor	≥95.0%	Unkown
HY-100642S	3-O-Methyltolcapone-d7	Inhibitor	≥99.0%	Unkown
HY-17406S	Tolcapone-d7	Inhibitor	/	Unkown
HY-100642S1	3-O-Methyltolcapone-d4	Inhibitor	/	Unkown
HY-169611	Serotonin maleate	Inhibitor	/	Unkown
HY-139089	(Z)-Entacapone	Inhibitor	/	Unkown
HY-100642	3-O-Methyltolcapone	Inhibitor	99.95%	Unkown
HY-133068A	(E)-5-Hydroxyferulic acid		/	Unkown
HY-162760	COMT-IN-1	Inhibitor	/	Unkown
HY-120325	DHMPA	Inhibitor	/	Unkown
HY-151390	hMAO-B/MB-COMT-IN-2	Inhibitor	/	Unkown
HY-168154	COMT-IN-2	Inhibitor	/	Unkown
HY-156069	Methylspinazarin	Inhibitor	/	Unkown
HY-119224	BIA 3-335	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Comt	NCBI	NCBI:1312

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