Scd - stearoyl-CoA desaturase Gene

Rattus norvegicus

Also known as Scd1

Gene ID: 246074 | Gene type: protein coding

About Scd

Primary_assembly 1: 243,269,747-243,282,562 reverse strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 29 orthologues, 3 paralogues and is associated with 16 phenotypes. Biased expression in Liver (RPKM 4781.4), Adrenal (RPKM 4523.2) and 5 other tissues.

Summary

Enables iron ion binding activity and stearoyl-CoA 9-desaturase activity. Involved in response to fatty acid and unsaturated fatty acid biosynthetic process. Located in intracellular membrane-bounded organelle. Is integral component of membrane. Used to study carcinoma. Biomarker of hyperinsulinism. Orthologous to human SCD (stearoyl-CoA desaturase). [provided by Alliance of Genome Resources, Apr 2022]

Scd Products(1)

mRNA	Protein	Name
NM_139192.2	NP_631931.2	acyl-CoA desaturase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables iron ion binding	IDA IDA: Inferred from direct assay	2892838	RGD
enables oxidoreductase activity	IMP IMP: Inferred from mutant phenotype	7947684	RGD
enables stearoyl-CoA 9-desaturase activity	IDA IDA: Inferred from direct assay	2892838	RGD
enables stearoyl-CoA 9-desaturase activity	IMP IMP: Inferred from mutant phenotype	7947684	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in lipid biosynthetic process	IEP IEP: Inferred from expression pattern	12896875	RGD
involved in response to fatty acid	IDA IDA: Inferred from direct assay	1982442	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	26394137	RGD
involved in unsaturated fatty acid biosynthetic process	IDA IDA: Inferred from direct assay	2892838	RGD
involved in unsaturated fatty acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	7947684	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	2892838	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Scd Protein Structure

Delta9-FADS-like

0
100
200
300
358 a.a.

Protein Preferred Names

Protein Names

acyl-CoA desaturase 1

delta(9)-desaturase 1	fatty acid desaturase 1
stearoyl-CoA desaturase 1	stearoyl-Coenzyme A desaturase 1

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18681	Voxelotor	Inhibitor	99.97%	Yes

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-19796	Icomidocholic acid		≥99.0%	Phase 3
HY-13070	MK-8245	Inhibitor	99.04%	Phase 2
HY-13077	MK-8245 Trifluoroacetate	Inhibitor	98.09%	Phase 2
HY-19762	GSK1940029	Inhibitor	99.82%	Phase 1

Pre-clinical Phase

Bioactive Molecules (41)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-50709	A939572	Inhibitor	99.98%	Unkown
HY-15823	CAY10566	Inhibitor	99.82%	Unkown
HY-15700	PluriSIn 1		99.84%	Unkown
HY-15822	MF-438	Inhibitor	99.92%	Unkown
HY-12756A	E6446 dihydrochloride		99.96%	Unkown
HY-124751	YTX-465	Inhibitor	99.06%	Unkown
HY-N6807	Elemicin	Inhibitor	99.22%	Unkown
HY-124876	SynuClean-D		99.89%	Unkown
HY-148788	Osivelotor		99.83%	Unkown
HY-124346	T-3364366	Inhibitor	99.73%	Unkown
HY-141525	SCD1 inhibitor-4	Inhibitor	98.93%	Unkown
HY-P3180	Hemoglobin S		≥99.0%	Unkown
HY-100249	XEN723	Inhibitor	99.90%	Unkown
HY-127143	Sterculic acid	Inhibitor	≥99.0%	Unkown
HY-155033	SSI-4	Inhibitor	99.95%	Unkown
HY-12756	E6446		≥98.0%	Unkown
HY-11034	CVT-12012	Inhibitor	99.16%	Unkown
HY-113638	CVT-11127		99.88%	Unkown
HY-112812	SCD1 inhibitor-1	Inhibitor	99.78%	Unkown
HY-139077	SCD1 inhibitor-3	Inhibitor	98.55%	Unkown
HY-159098	dWIZ-1	Degrader	/	Unkown
HY-102045	T-3764518	Inhibitor	99.86%	Unkown
HY-155403	SCD1/5-IN-1	Inhibitor	99.58%	Unkown
HY-E70265	18:0 Coenzyme A triammonium		≥99.0%	Unkown
HY-132847	Vibozilimod	Agonist	99.52%	Unkown
HY-139293	PF-07059013		/	Unkown
HY-111315	XEN103	Inhibitor	/	Unkown
HY-114184	MK-8245 analog	Inhibitor	/	Unkown
HY-118117	Rovatirelin		/	Unkown
HY-150125	SCD1-IN-1	Inhibitor	/	Unkown
HY-152775A	RK-0133114	Inhibitor	/	Unkown
HY-159099	HbF inducer 2	Degrader	/	Unkown
HY-161787	G9a-IN-2	Inhibitor	/	Unkown
HY-RS12494	SCD Human Pre-designed siRNA Set A		/	Unkown
HY-RS12495	Scd Rat Pre-designed siRNA Set A		/	Unkown
HY-RS12496	Scd1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12497	SCD5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-155209	SCD1 inhibitor-5	Inhibitor	/	Unkown
HY-163820	WIZ degrader 4	Degrader	/	Unkown
HY-163824	WIZ degrader 7	Degrader	/	Unkown
HY-W013627S	trans,trans-2,4-Decadienal-d4		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Scd	NCBI	NCBI:6319
Canis familiaris	Scd	NCBI	NCBI:486839
Macaca fascicularis	Scd	NCBI	NCBI:102120948
Mus musculus	Scd	NCBI
Leporidae	Scd	NCBI
Macaca mulatta	Scd	NCBI	NCBI:710155

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