2. Gene
  3. SCD - stearoyl-CoA desaturase Gene

SCD - stearoyl-CoA desaturase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SCD1; FADS5; SCDOS; hSCD1; MSTP008

Gene ID: 6319 | Gene type: protein coding

About SCD

Cytogenetic location: 10q24.31 Genomic coordinates (GRCh38): 10:100,347,233-100,364,826 (from NCBI)

This gene has 1 transcript (splice variant), 312 orthologues and 1 paralogue. Biased expression in fat (RPKM 972.1), brain (RPKM 238.0) and 4 other tissues.

Summary

This gene encodes an Enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid desaturase family and is an integral membrane protein located in the endoplasmic reticulum. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar Enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17. [provided by RefSeq, Sep 2015]

SCD Products(1)

mRNA Protein Name
NM_005063.5 NP_005054.3 stearoyl-CoA desaturase

SCD Protein Structure

FA_desaturase

FA_desaturase: Fatty acid desaturase (100 - 308)

  • 0
  • 100
  • 200
  • 300
  • 359 a.a.
Protein Preferred Names Protein Names

stearoyl-CoA desaturase

acyl-CoA desaturase

delta(9)-desaturase

fatty acid desaturase

predicted protein of HQ0998

stearoyl-CoA desaturase (delta-9-desaturase)

stearoyl-CoA desaturase opposite strand

SCD Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra SCD O00767 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
Intra SCD O00767 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra SCD O00767 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra SCD O00767 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra SCD O00767 JAGN1 Homo sapiens Q8N5M9
Validated Y2H
32296183
Intra SCD O00767 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra SCD O00767 VMA21 Homo sapiens Q3ZAQ7
Y2H Prey Pooling
32296183
Intra SCD O00767 VMA21 Homo sapiens Q3ZAQ7
Validated Y2H
32296183
Intra SCD O00767 VMA21 Homo sapiens Q3ZAQ7
Y2H Array
32296183
Intra SCD O00767 SPAG4 Homo sapiens Q9NPE6
Validated Y2H
32296183
Intra SCD O00767 SPAG4 Homo sapiens Q9NPE6
Y2H Array
32296183
Intra SCD O00767 SPAG4 Homo sapiens Q9NPE6
Y2H Prey Pooling
32296183
Intra SCD O00767 REEP2 Homo sapiens Q9BRK0
Y2H Prey Pooling
32296183
Intra SCD O00767 REEP2 Homo sapiens Q9BRK0
Validated Y2H
32296183
Intra SCD O00767 REEP2 Homo sapiens Q9BRK0
Y2H Array
32296183
Intra SCD O00767 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra SCD O00767 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra SCD O00767 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra SCD O00767 KCNJ6 Homo sapiens P48051
Y2H Prey Pooling
32296183
Intra SCD O00767 KCNJ6 Homo sapiens P48051
Validated Y2H
32296183
Intra SCD O00767 KCNJ6 Homo sapiens P48051
Y2H Array
32296183
Intra SCD O00767 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra SCD O00767 STOM Homo sapiens P27105
Validated Y2H
32296183
Intra SCD O00767 STOM Homo sapiens P27105
Y2H Array
32296183
Intra SCD O00767 TMPRSS2 Homo sapiens O15393-2
Complementation
32296183
Intra SCD O00767 TMPRSS2 Homo sapiens O15393-2
Validated Y2H
32296183
Intra SCD O00767 TMPRSS2 Homo sapiens O15393-2
Y2H Prey Pooling
32296183
Intra SCD O00767 TMPRSS2 Homo sapiens O15393-2
Y2H Array
32296183
Intra SCD O00767 CLEC12B Homo sapiens Q2HXU8-2
Y2H Prey Pooling
32296183
Intra SCD O00767 CLEC12B Homo sapiens Q2HXU8-2
Validated Y2H
32296183
Intra SCD O00767 CLEC12B Homo sapiens Q2HXU8-2
Y2H Array
32296183
Intra SCD O00767 TLCD4 Homo sapiens Q96MV1
Validated Y2H
32296183
Intra SCD O00767 TLCD4 Homo sapiens Q96MV1
Y2H Array
32296183
Intra SCD O00767 TLCD4 Homo sapiens Q96MV1
Y2H Prey Pooling
32296183
Intra SCD O00767 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra SCD O00767 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra SCD O00767 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra SCD O00767 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra SCD O00767 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra SCD O00767 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra SCD O00767 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra SCD O00767 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra SCD O00767 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra SCD O00767 GJB1 Homo sapiens P08034
Validated Y2H
32296183
Intra SCD O00767 GJB1 Homo sapiens P08034
Y2H Prey Pooling
32296183
Intra SCD O00767 GJB1 Homo sapiens P08034
Y2H Array
32296183
Intra SCD O00767 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra SCD O00767 HSD17B13 Homo sapiens Q7Z5P4
Validated Y2H
32296183
Intra SCD O00767 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra SCD O00767 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra SCD O00767 GPR42 Homo sapiens O15529
Validated Y2H
32296183
Intra SCD O00767 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra SCD O00767 SLC10A6 Homo sapiens Q3KNW5
Validated Y2H
32296183
Intra SCD O00767 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra SCD O00767 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra SCD O00767 MARCHF5 Homo sapiens Q9NX47
Y2H Prey Pooling
32296183
Intra SCD O00767 MARCHF5 Homo sapiens Q9NX47
Validated Y2H
32296183
Intra SCD O00767 MARCHF5 Homo sapiens Q9NX47
Y2H Array
32296183
Intra SCD O00767 CERS4 Homo sapiens Q9HA82
Y2H Prey Pooling
32296183
Intra SCD O00767 CERS4 Homo sapiens Q9HA82
Validated Y2H
32296183
Intra SCD O00767 CYBC1 Homo sapiens Q9BQA9
Y2H Prey Pooling
32296183
Intra SCD O00767 CYBC1 Homo sapiens Q9BQA9
Validated Y2H
32296183
Intra SCD O00767 CYBC1 Homo sapiens Q9BQA9
Y2H Array
32296183
Intra SCD O00767 MCFD2 Homo sapiens Q8NI22
Validated Y2H
32296183
Intra SCD O00767 MCFD2 Homo sapiens Q8NI22
Y2H Array
32296183
Intra SCD O00767 MCFD2 Homo sapiens Q8NI22
Y2H Prey Pooling
32296183
Intra SCD O00767 SEC11C Homo sapiens Q9BY50
Validated Y2H
32296183
Intra SCD O00767 SEC11C Homo sapiens Q9BY50
Y2H Array
32296183
Intra SCD O00767 SEC11C Homo sapiens Q9BY50
Y2H Prey Pooling
32296183
Intra SCD O00767 CD207 Homo sapiens Q9UJ71
Y2H Prey Pooling
32296183
Intra SCD O00767 CD207 Homo sapiens Q9UJ71
Validated Y2H
32296183
Intra SCD O00767 CD207 Homo sapiens Q9UJ71
Y2H Array
32296183
Intra SCD O00767 RNF5 Homo sapiens Q99942
Validated Y2H
32296183
Intra SCD O00767 RNF5 Homo sapiens Q99942
Y2H Prey Pooling
32296183
Intra SCD O00767 RNF5 Homo sapiens Q99942
Y2H Array
32296183
Intra SCD O00767 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
Intra SCD O00767 MFSD14B Homo sapiens Q5SR56
Validated Y2H
32296183
Intra SCD O00767 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
Intra SCD O00767 CD33 Homo sapiens P20138
Validated Y2H
32296183
Intra SCD O00767 CD33 Homo sapiens P20138
Y2H Array
32296183
Intra SCD O00767 CD33 Homo sapiens P20138
Y2H Prey Pooling
32296183
Intra SCD O00767 PVR Homo sapiens P15151
Validated Y2H
32296183
Intra SCD O00767 PVR Homo sapiens P15151
Y2H Array
32296183
Intra SCD O00767 PVR Homo sapiens P15151
Y2H Prey Pooling
32296183
Intra SCD O00767 MTIF3 Homo sapiens Q9H2K0
Y2H Prey Pooling
32296183
Intra SCD O00767 MTIF3 Homo sapiens Q9H2K0
Validated Y2H
32296183
Intra SCD O00767 MTIF3 Homo sapiens Q9H2K0
Y2H Array
32296183
Intra SCD O00767 SLC7A14 Homo sapiens Q8TBB6
Y2H Prey Pooling
32296183
Intra SCD O00767 SLC7A14 Homo sapiens Q8TBB6
Y2H Array
32296183
Intra SCD O00767 SLC7A14 Homo sapiens Q8TBB6
Validated Y2H
32296183
Intra SCD O00767 TIMMDC1 Homo sapiens Q9NPL8
Y2H Array
32296183
Intra SCD O00767 TIMMDC1 Homo sapiens Q9NPL8
Y2H Prey Pooling
32296183
Intra SCD O00767 TIMMDC1 Homo sapiens Q9NPL8
Validated Y2H
32296183
Intra SCD O00767 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra SCD O00767 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra SCD O00767 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra SCD O00767 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra SCD O00767 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra SCD O00767 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra SCD O00767 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra SCD O00767 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra SCD O00767 MGST3 Homo sapiens O14880
Validated Y2H
32296183
Intra SCD O00767 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra SCD O00767 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra SCD O00767 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra SCD O00767 CYB561 Homo sapiens P49447
Validated Y2H
32296183
Intra SCD O00767 CYB561 Homo sapiens P49447
Y2H Array
32296183
Intra SCD O00767 CYB561 Homo sapiens P49447
Y2H Prey Pooling
32296183
Intra SCD O00767 TMEM30B Homo sapiens Q3MIR4
Y2H Prey Pooling
32296183
Intra SCD O00767 TMEM30B Homo sapiens Q3MIR4
Y2H Array
32296183
Intra SCD O00767 TMEM30B Homo sapiens Q3MIR4
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Abdominal Obesity-Metabolic Syndrome 1

Metabolic Syndrome X

Metabolic Syndrome

AOMS1

Dysmetabolic Syndrome X

Metabolic Disease

Abdominal Obesity Metabolic Syndrome
Non-Alcoholic Fatty Liver Disease

Fatty Liver

Non-Alcoholic Fatty Liver

Nafld

Nonalcoholic Fatty Liver Disease

Nonalcoholic Steatohepatitis

Steatosis

Nafl

Nash

Non-Alcoholic Steatohepatitis

Susceptibility To Nonalcoholic Fatty Liver Disease

Steatohepatitis

Fatty Degeneration

Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis

Nafld Without Nash

Nafld Without Mention Of Nash
Non-Alcoholic Steatohepatitis

Nonalcoholic Steatohepatitis

Nash

Nash - [Non-Alcoholic Steatohepatitis]

Non-Alcoholic Steatohepatosis
Skin Disease

Skin Diseases

Abnormality Of The Skin

Skin Diseases, Genetic

Genodermatosis

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders
Fatty Liver Disease

Alcoholic Fatty Liver

Fatty Liver

Fatty Liver, Alcoholic

Fatty Change Of Liver

Hepatic Lipidosis

Steatosis Of Liver

Fatty Liver Alcoholic

Steatohepatitis

Etoh Fatty Liver

Etoh Fatty Liver Metamorphosis

Fatty Etoh Liver Necrosis
Lipid Storage Disease

Lipoidosis

Inborn Lipid Storage Disorder

Lipoid Storage Diseas

Lipid Storage Diseases

Lipidoses
Fetal Akinesia Deformation Sequence 1

Fetal Akinesia Deformation Sequence

Fads

Fetal Akinesia Sequence

FADS1

Arthrogryposis Multiplex Congenita With Pulmonary Hypoplasia

Pena-Shokeir Syndrome Type 1

Fetal Akinesia Deformation Sequence Syndrome

Arthrogryposis Multiplex Congenita-Pulmonary Hypoplasia Syndrome

Arthrogryposis Multiplex Congenita Pulmonary Hypoplasia

Pena-Shokeir Syndrome, Type I

Foetal Akinesia Deformation Sequence Syndrome

Foetal Akinesia Sequence

Fetal Akinesia Deformation Sequence Syndrome 1

Pena-Shokeir Syndrome, Type 1

Pena Shokeir Syndrome, Type 1

Akinesia, Fetal, Deformation Sequence

Akinesia, Fetal, Deformation Sequence, Type 1

Pena-Shokeir Syndrome Type I
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Obesity , Susceptibility To

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Diabetes Mellitus

Diabetes
Homocystinuria

Cystathionine Beta Synthase Deficiency

Homocysteinemia

Cbs Deficiency

Cystathionine Synthase Deficiency

Cystathionine Beta-Synthase Deficiency Disease
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Diabetes Mellitus, Non-Insulin-Dependent

Type 2 Diabetes

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18681 Voxelotor Inhibitor 99.97% Yes
Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-19796 Icomidocholic acid ≥99.0% Phase 3
HY-13070 MK-8245 Inhibitor 99.04% Phase 2
HY-13077 MK-8245 Trifluoroacetate Inhibitor 98.09% Phase 2
HY-19762 GSK1940029 Inhibitor 99.82% Phase 1
Pre-clinical Phase
Bioactive Molecules (41)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50709 A939572 Inhibitor 99.98% Unkown
HY-15823 CAY10566 Inhibitor 99.82% Unkown
HY-15822 MF-438 Inhibitor 99.92% Unkown
HY-15700 PluriSIn 1 99.84% Unkown
HY-12756A E6446 dihydrochloride 99.96% Unkown
HY-124751 YTX-465 Inhibitor 99.06% Unkown
HY-124876 SynuClean-D 99.89% Unkown
HY-148788 Osivelotor 99.83% Unkown
HY-N6807 Elemicin Inhibitor 99.22% Unkown
HY-124346 T-3364366 Inhibitor 99.73% Unkown
HY-100249 XEN723 Inhibitor 99.90% Unkown
HY-127143 Sterculic acid Inhibitor ≥99.0% Unkown
HY-12756 E6446 ≥98.0% Unkown
HY-P3180 Hemoglobin S ≥99.0% Unkown
HY-11034 CVT-12012 Inhibitor 99.16% Unkown
HY-141525 SCD1 inhibitor-4 Inhibitor 98.93% Unkown
HY-155033 SSI-4 Inhibitor 99.95% Unkown
HY-113638 CVT-11127 99.88% Unkown
HY-112812 SCD1 inhibitor-1 Inhibitor 99.78% Unkown
HY-139077 SCD1 inhibitor-3 Inhibitor 98.55% Unkown
HY-159098 dWIZ-1 Degrader / Unkown
HY-102045 T-3764518 Inhibitor 99.86% Unkown
HY-155403 SCD1/5-IN-1 Inhibitor 99.58% Unkown
HY-E70265 18:0 Coenzyme A triammonium ≥99.0% Unkown
HY-132847 Vibozilimod Agonist 99.52% Unkown
HY-139293 PF-07059013 / Unkown
HY-111315 XEN103 Inhibitor / Unkown
HY-114184 MK-8245 analog Inhibitor / Unkown
HY-118117 Rovatirelin / Unkown
HY-150125 SCD1-IN-1 Inhibitor / Unkown
HY-152775A RK-0133114 Inhibitor / Unkown
HY-159099 HbF inducer 2 Degrader / Unkown
HY-161787 G9a-IN-2 Inhibitor / Unkown
HY-RS12494 SCD Human Pre-designed siRNA Set A / Unkown
HY-RS12495 Scd Rat Pre-designed siRNA Set A / Unkown
HY-RS12496 Scd1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS12497 SCD5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-155209 SCD1 inhibitor-5 Inhibitor / Unkown
HY-163820 WIZ degrader 4 Degrader / Unkown
HY-163824 WIZ degrader 7 Degrader / Unkown
HY-W013627S trans,trans-2,4-Decadienal-d4 / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SCD VGNC VGNC:106098
Bos taurus SCD VGNC VGNC:106916
Felis catus SCD VGNC VGNC:64904
Rattus norvegicus SCD RGD RGD:621176
Canis familiaris SCD VGNC VGNC:45900
Macaca fascicularis SCD NCBI NCBI:102120948
Mus musculus SCD NCBI
Leporidae SCD NCBI
Others SCD NCBI