SCD - stearoyl-CoA desaturase Gene

Homo sapiens

Also known as SCD1; FADS5; SCDOS; hSCD1; MSTP008

Gene ID: 6319 | Gene type: protein coding

About SCD

Cytogenetic location: 10q24.31 Genomic coordinates (GRCh38): 10:100,347,233-100,364,826 (from NCBI)

This gene has 1 transcript (splice variant), 312 orthologues and 1 paralogue. Biased expression in fat (RPKM 972.1), brain (RPKM 238.0) and 4 other tissues.

Summary

This gene encodes an Enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid desaturase family and is an integral membrane protein located in the endoplasmic reticulum. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar Enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17. [provided by RefSeq, Sep 2015]

SCD Products(1)

mRNA	Protein	Name
NM_005063.5	NP_005054.3	stearoyl-CoA desaturase

SCD Protein Structure

FA_desaturase

0
100
200
300
359 a.a.

Protein Preferred Names

Protein Names

stearoyl-CoA desaturase

acyl-CoA desaturase	delta(9)-desaturase
fatty acid desaturase	predicted protein of HQ0998
stearoyl-CoA desaturase (delta-9-desaturase)	stearoyl-CoA desaturase opposite strand

Related Diseases

Diseases

Alias

Abdominal Obesity-Metabolic Syndrome 1

Metabolic Syndrome X	Metabolic Syndrome
AOMS1	Dysmetabolic Syndrome X
Metabolic Disease	Abdominal Obesity Metabolic Syndrome

Non-Alcoholic Fatty Liver Disease

Fatty Liver	Non-Alcoholic Fatty Liver
Nafld	Nonalcoholic Fatty Liver Disease
Nonalcoholic Steatohepatitis	Steatosis
Nafl	Nash
Non-Alcoholic Steatohepatitis	Susceptibility To Nonalcoholic Fatty Liver Disease
Steatohepatitis	Fatty Degeneration
Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis	Nafld Without Nash
Nafld Without Mention Of Nash

Non-Alcoholic Steatohepatitis

Nonalcoholic Steatohepatitis	Nash
Nash - [Non-Alcoholic Steatohepatitis]	Non-Alcoholic Steatohepatosis

Skin Disease

Skin Diseases	Abnormality Of The Skin
Skin Diseases, Genetic	Genodermatosis
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Fatty Liver Disease

Alcoholic Fatty Liver	Fatty Liver
Fatty Liver, Alcoholic	Fatty Change Of Liver
Hepatic Lipidosis	Steatosis Of Liver
Fatty Liver Alcoholic	Steatohepatitis
Etoh Fatty Liver	Etoh Fatty Liver Metamorphosis
Fatty Etoh Liver Necrosis

Lipid Storage Disease

Lipoidosis	Inborn Lipid Storage Disorder
Lipoid Storage Diseas	Lipid Storage Diseases
Lipidoses

Fetal Akinesia Deformation Sequence 1

Fetal Akinesia Deformation Sequence	Fads
Fetal Akinesia Sequence	FADS1
Arthrogryposis Multiplex Congenita With Pulmonary Hypoplasia	Pena-Shokeir Syndrome Type 1
Fetal Akinesia Deformation Sequence Syndrome	Arthrogryposis Multiplex Congenita-Pulmonary Hypoplasia Syndrome
Arthrogryposis Multiplex Congenita Pulmonary Hypoplasia	Pena-Shokeir Syndrome, Type I
Foetal Akinesia Deformation Sequence Syndrome	Foetal Akinesia Sequence
Fetal Akinesia Deformation Sequence Syndrome 1	Pena-Shokeir Syndrome, Type 1
Pena Shokeir Syndrome, Type 1	Akinesia, Fetal, Deformation Sequence
Akinesia, Fetal, Deformation Sequence, Type 1	Pena-Shokeir Syndrome Type I

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
BMIQ11	Obesity Bmiq11
Obesity, Early-Onset	Obesity , Susceptibility To
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Diabetes Mellitus

Diabetes

Homocystinuria

Cystathionine Beta Synthase Deficiency	Homocysteinemia
Cbs Deficiency	Cystathionine Synthase Deficiency
Cystathionine Beta-Synthase Deficiency Disease

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Diabetes Mellitus, Non-Insulin-Dependent	Type 2 Diabetes
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18681	Voxelotor	Inhibitor	99.97%	Yes

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-19796	Icomidocholic acid		≥99.0%	Phase 3
HY-13070	MK-8245	Inhibitor	99.04%	Phase 2
HY-13077	MK-8245 Trifluoroacetate	Inhibitor	98.09%	Phase 2
HY-19762	GSK1940029	Inhibitor	99.82%	Phase 1

Pre-clinical Phase

Bioactive Molecules (41)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-50709	A939572	Inhibitor	99.98%	Unkown
HY-15823	CAY10566	Inhibitor	99.82%	Unkown
HY-15822	MF-438	Inhibitor	99.92%	Unkown
HY-15700	PluriSIn 1		99.84%	Unkown
HY-12756A	E6446 dihydrochloride		99.96%	Unkown
HY-124751	YTX-465	Inhibitor	99.06%	Unkown
HY-124876	SynuClean-D		99.89%	Unkown
HY-N6807	Elemicin	Inhibitor	99.22%	Unkown
HY-148788	Osivelotor		99.83%	Unkown
HY-124346	T-3364366	Inhibitor	99.73%	Unkown
HY-100249	XEN723	Inhibitor	99.90%	Unkown
HY-127143	Sterculic acid	Inhibitor	≥99.0%	Unkown
HY-P3180	Hemoglobin S		≥99.0%	Unkown
HY-141525	SCD1 inhibitor-4	Inhibitor	98.93%	Unkown
HY-11034	CVT-12012	Inhibitor	99.16%	Unkown
HY-113638	CVT-11127		99.88%	Unkown
HY-155033	SSI-4	Inhibitor	99.95%	Unkown
HY-12756	E6446		≥98.0%	Unkown
HY-139077	SCD1 inhibitor-3	Inhibitor	98.55%	Unkown
HY-112812	SCD1 inhibitor-1	Inhibitor	99.78%	Unkown
HY-102045	T-3764518	Inhibitor	99.86%	Unkown
HY-155403	SCD1/5-IN-1	Inhibitor	99.58%	Unkown
HY-159098	dWIZ-1		/	Unkown
HY-132847	Vibozilimod	Agonist	99.52%	Unkown
HY-139293	PF-07059013		/	Unkown
HY-111315	XEN103	Inhibitor	/	Unkown
HY-114184	MK-8245 analog	Inhibitor	/	Unkown
HY-118117	Rovatirelin		/	Unkown
HY-150125	SCD1-IN-1	Inhibitor	/	Unkown
HY-152775A	RK-0133114	Inhibitor	/	Unkown
HY-159099	HbF inducer 2		/	Unkown
HY-161787	G9a-IN-2	Inhibitor	/	Unkown
HY-E70265	18:0 Coenzyme A triammonium		/	Unkown
HY-RS12494	SCD Human Pre-designed siRNA Set A		/	Unkown
HY-RS12495	Scd Rat Pre-designed siRNA Set A		/	Unkown
HY-RS12496	Scd1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12497	SCD5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-155209	SCD1 inhibitor-5	Inhibitor	/	Unkown
HY-163820	WIZ degrader 4		/	Unkown
HY-163824	WIZ degrader 7		/	Unkown
HY-W013627S	trans,trans-2,4-Decadienal-d4		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SCD	VGNC	VGNC:106098
Bos taurus	SCD	VGNC	VGNC:106916
Felis catus	SCD	VGNC	VGNC:64904
Rattus norvegicus	SCD	RGD	RGD:621176
Canis familiaris	SCD	VGNC	VGNC:45900
Macaca fascicularis	SCD	NCBI	NCBI:102120948
Mus musculus	SCD	NCBI
Leporidae	SCD	NCBI
Others	SCD	NCBI

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