2. Gene
  3. Cdk8 - cyclin-dependent kinase 8 Gene

Cdk8 - cyclin-dependent kinase 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 264064 | Gene type: protein coding

About Cdk8

Chromosome 5: 146,168,040-146,239,684 forward strand.GRCm39:CM000998.3

This gene has 9 transcripts (splice variants), 217 orthologues, 25 paralogues and is associated with 17 phenotypes. Ubiquitous expression in adrenal adult (RPKM 21.2), ovary adult (RPKM 18.4) and 28 other tissues.

Summary

Predicted to enable RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within phosphorylation. Part of mediator complex. Is expressed in embryo. Orthologous to human CDK8 (cyclin dependent kinase 8). [provided by Alliance of Genome Resources, Apr 2022]

Cdk8 Products(3)

mRNA Protein Name
NM_001359991.1 NP_001346920.1 cyclin-dependent kinase 8 isoform 3
NM_001359990.1 NP_001346919.1 cyclin-dependent kinase 8 isoform 2
NM_153599.4 NP_705827.2 cyclin-dependent kinase 8 isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
20720539 MGI
Cellular Component GO Annotation Evidence Reference Source
part of mediator complex IDA
IDA: Inferred from direct assay
15340084 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cdk8 Protein Structure

STKc_CDK8

STKc_CDK8: cd07868 (2 - 334)

  • 0
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  • 400
  • 464 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 8

cell division protein kinase 8

mediator complex subunit CDK8

mediator of RNA polymerase II transcription subunit CDK8

Cdk8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Cdk8 Q8R3L8 Med12 Mus musculus A2AGH6
Anti Bait CoIP
20720539
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (35)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0400 Wogonin Inhibitor 99.92% Unkown
HY-120350 BI-1347 Inhibitor 99.84% Unkown
HY-126675A AS2863619 Inhibitor 99.94% Unkown
HY-101611 MSC2530818 Inhibitor 99.62% Unkown
HY-111388A SEL120-34A monohydrochloride Inhibitor 99.29% Unkown
HY-19984 CCT-251921 Inhibitor 99.01% Unkown
HY-15681 Senexin A Inhibitor 99.79% Unkown
HY-12280 THZ2 Inhibitor 99.03% Unkown
HY-122586 BRD6989 Inhibitor 99.56% Unkown
HY-12293 LY2857785 Inhibitor 99.92% Unkown
HY-111388B SEL120-34A hydrochloride Inhibitor 99.98% Unkown
HY-111518 JH-XI-10-02 Inhibitor 99.82% Unkown
HY-145121 DS96432529 Inhibitor 99.58% Unkown
HY-101800 Senexin B Inhibitor 99.72% Unkown
HY-139875 JH-XVI-178 Inhibitor 98.16% Unkown
HY-126675 AS2863619 free base Inhibitor 99.87% Unkown
HY-151463 CDK8-IN-11 Inhibitor 98.20% Unkown
HY-149974 CDK8-IN-13 Inhibitor 99.14% Unkown
HY-143889 Senexin C Inhibitor 98.06% Unkown
HY-103492 CDK8-IN-1 Inhibitor 99.77% Unkown
HY-149209 LL-K8-22 Degrader 99.76% Unkown
HY-111427 CDK8/19-IN-1 Inhibitor 98.03% Unkown
HY-X0009A JSH-009 dimaleate Inhibitor / Unkown
HY-111388 SEL120-34A Inhibitor / Unkown
HY-15681A Senexin A hydrochloride Inhibitor / Unkown
HY-125001 JH-VIII-49 Inhibitor / Unkown
HY-158377 CDK8/19-IN-2 Inhibitor / Unkown
HY-147527 CDK8-IN-5 Inhibitor / Unkown
HY-147716 CDK8-IN-6 Inhibitor / Unkown
HY-147717 CDK8-IN-7 Inhibitor / Unkown
HY-151371 CDK8-IN-10 Inhibitor / Unkown
HY-168683 CDK8 ligand 1 Degrader / Unkown
HY-162600 CDK8-IN-15 Inhibitor / Unkown
HY-148561 CDK8-IN-12 Inhibitor 99.74% Unkown
HY-N0400R Wogonin (Standard) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk8 NCBI NCBI:1024