2. Gene
  3. KRT6C - keratin 6C Gene

KRT6C - keratin 6C Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as K6E; KRT6E; PPKNEFD

Gene ID: 286887 | Gene type: protein coding

About KRT6C

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,468,516-52,473,805 (from NCBI)

This gene has 2 transcripts (splice variants), 143 orthologues, 68 paralogues and is associated with 2 phenotypes. Restricted expression toward esophagus (RPKM 948.5).

Summary

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jul 2009]

KRT6C Products(1)

mRNA Protein Name
NM_173086.5 NP_775109.2 keratin, type II cytoskeletal 6C
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in intermediate filament cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
23662636 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT6C Protein Structure

Filament

Filament: Intermediate filament protein (162 - 475)

  • 0
  • 100
  • 200
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  • 400
  • 500
  • 564 a.a.
Protein Preferred Names Protein Names

keratin, type II cytoskeletal 6C

CK-6C

KRT6C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
KRT6C P48668 KRT13 Homo sapiens A1A4E9
Y2H Prey Pooling
25416956
Intra
KRT6C P48668 KRT13 Homo sapiens A1A4E9
Validated Y2H
25416956
Intra
KRT6C P48668 KRT40 Homo sapiens Q6A162
Y2H Array
32296183
Intra
KRT6C P48668 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra
KRT6C P48668 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
32296183
Intra
KRT6C P48668 KRT40 Homo sapiens Q6A162
Validated Y2H
32296183
Intra
KRT6C P48668 KRT37 Homo sapiens O76014
Y2H Array
32296183
Intra
KRT6C P48668 KRT37 Homo sapiens O76014
Y2H Prey Pooling
32296183
Intra
KRT6C P48668 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
KRT6C P48668 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
KRT6C P48668 KRT38 Homo sapiens O76015
Y2H Array
32296183
Intra
KRT6C P48668 KRT38 Homo sapiens O76015
Y2H Prey Pooling
25416956
Intra
KRT6C P48668 KRT38 Homo sapiens O76015
Y2H Prey Pooling
32296183
Intra
KRT6C P48668 KRT33B Homo sapiens Q14525
Y2H Array
32296183
Intra
KRT6C P48668 KRT33B Homo sapiens Q14525
Y2H Prey Pooling
32296183
Intra
KRT6C P48668 KRT33B Homo sapiens Q14525
Validated Y2H
32296183
Intra
KRT6C P48668 KRT35 Homo sapiens Q92764
Y2H Prey Pooling
32296183
Intra
KRT6C P48668 KRT35 Homo sapiens Q92764
Validated Y2H
32296183
Intra
KRT6C P48668 KRT35 Homo sapiens Q92764
Y2H Array
32296183
Intra
KRT6C P48668 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
25416956
Intra
KRT6C P48668 KRT36 Homo sapiens O76013-2
Y2H Prey Pooling
32296183
Intra
KRT6C P48668 KRT36 Homo sapiens O76013-2
Y2H Array
32296183
Intra
KRT6C P48668 KRT25 Homo sapiens Q7Z3Z0
Y2H Prey Pooling
32296183
Intra
KRT6C P48668 KRT25 Homo sapiens Q7Z3Z0
Validated Y2H
32296183
Intra
KRT6C P48668 KRT25 Homo sapiens Q7Z3Z0
Y2H Array
32296183
Intra
KRT6C P48668 KRT26 Homo sapiens Q7Z3Y9
Y2H Prey Pooling
32296183
Intra
KRT6C P48668 KRT26 Homo sapiens Q7Z3Y9
Y2H Array
32296183
Intra
KRT6C P48668 KRT26 Homo sapiens Q7Z3Y9
Validated Y2H
32296183
Intra
KRT6C P48668 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
Intra
KRT6C P48668 KIFC3 Homo sapiens Q9BVG8-5
Y2H Array
32296183
Intra
KRT6C P48668 KIFC3 Homo sapiens Q9BVG8-5
Y2H Prey Pooling
32296183
Intra
KRT6C P48668 KIFC3 Homo sapiens Q9BVG8
Y2H Array
25416956
Intra
KRT6C P48668 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
Intra
KRT6C P48668 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
32296183
Intra
KRT6C P48668 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
25416956
Intra
KRT6C P48668 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
Intra
KRT6C P48668 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
25416956
Intra
KRT6C P48668 TRIM54 Homo sapiens Q9BYV2
Y2H Array
25416956
Intra
KRT6C P48668 ACTN3 Homo sapiens Q08043
Validated Y2H
32296183
Intra
KRT6C P48668 KRT24 Homo sapiens Q2M2I5
Validated Y2H
32296183
Intra
KRT6C P48668 KRT24 Homo sapiens Q2M2I5
Y2H Array
32296183
Intra
KRT6C P48668 KRT24 Homo sapiens Q2M2I5
Y2H Prey Pooling
32296183
Intra
KRT6C P48668 KRT18 Homo sapiens P05783
Y2H Prey Pooling
32296183
Intra
KRT6C P48668 KRT18 Homo sapiens P05783
Y2H Array
32296183
Intra
KRT6C P48668 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra
KRT6C P48668 KRT27 Homo sapiens Q7Z3Y8
Validated Y2H
32296183
Intra
KRT6C P48668 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra
KRT6C P48668 KRT16 Homo sapiens P08779
Y2H Prey Pooling
32296183
Intra
KRT6C P48668 KRT16 Homo sapiens P08779
Y2H Array
32296183
Intra
KRT6C P48668 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra
KRT6C P48668 KRT14 Homo sapiens P02533
Y2H Array
32296183
Intra
KRT6C P48668 KRT15 Homo sapiens P19012
Y2H Array
25416956
Intra
KRT6C P48668 KRT19 Homo sapiens P08727
Y2H Array
32296183
Intra
KRT6C P48668 KRT19 Homo sapiens P08727
Y2H Prey Pooling
32296183
Intra
KRT6C P48668 KRT31 Homo sapiens Q15323
Validated Y2H
25416956
Intra
KRT6C P48668 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
KRT6C P48668 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
Intra
KRT6C P48668 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

KRT6C Antibodies

Cat. No. Product Name Application Reactivity
HY-P81574 Keratin 6 Antibody (YA1319) WB Human, Mouse, Rat
HY-P81956 Cytokeratin 6 Antibody (YA1701) WB, IHC-P, ICC/IF Human

Related Diseases

Diseases Alias
Palmoplantar Keratoderma, Nonepidermolytic, Focal Or Diffuse

PPKNEFD

Focal Or Diffuse Nonepidermolytic Palmoplantar Keratoderma

Autosomal Dominant Focal Non-Epidermolytic Palmoplantar Keratoderma With Plantar Blistering

Palmoplantar Keratoderma, Non-Epidermolytic, Focal Or Diffuse

Nonepidermolytic Focal Or Diffuse Palmoplantar Keratoderma

Keratoderma, Palmoplantar, Nonepidermolytic, Focal Or Diffuse
Focal Palmoplantar Keratoderma

Focal Ppk

Focal Keratosis Palmoplantaris

Focal Palmoplantar Hyperkeratosis
Diffuse Palmoplantar Keratoderma

Diffuse Palmoplantar Hyperkeratosis

Diffuse Ppk

Diffuse Keratosis Palmoplantaris
Norwegian Scabies

Crusted Scabies

Seven Year Itch
Pachyonychia Congenita 1

Pachyonychia Congenita

Jadassohn-Lewandowsky Syndrome

Pachyonychia Congenita Syndrome

PC1

Pachyonychia Congenita, Jadassohn-Lewandowsky Type

Congenital Pachyonychia

Pachyonychia Congenita, Type 1

Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly

Jadassohn-Lewandowsky Syndrome, Formerly

Jackson-Lawler Type Pachyonychia Congenita

Pachyonychia Congenita Type 1

Jackson-Lawler Syndrome

Jadassohn-Lewandowski Syndrome

Pc

Pachyonychia Congenita Jackson-Lawler Type

Pachyonychia Congenita Jadassohn-Lewandowsky Type

Pachyonychia Congenita Jackson Lawler Type

Pc-1

Pachyonychia Congenita, Jadassohn Lewandowsky Type

Pachyonychia Congenita, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07460 KRT6C Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus KRT6C RGD RGD:1588056