Il4 - interleukin 4 Gene

Rattus norvegicus

Also known as Il4e12

Gene ID: 287287 | Gene type: protein coding

About Il4

Primary_assembly 10: 37,771,203-37,776,750 reverse strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 92 orthologues and is associated with 113 phenotypes. Low expression observed in reference dataset.

Summary

Predicted to enable cytokine activity. Involved in several processes, including positive regulation of biosynthetic process; positive regulation of leukocyte migration; and regulation of defense response. Located in extracellular space. Used to study anti-basement membrane glomerulonephritis; autoimmune thyroiditis; and pelvic inflammatory disease. Biomarker of several diseases, including cerebrovascular disease (multiple); interstitial lung disease (multiple); irritant dermatitis; primary biliary cholangitis; and rhinitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic Cancer (multiple). Orthologous to human IL4 (interleukin 4). [provided by Alliance of Genome Resources, Apr 2022]

Il4 Products(1)

mRNA	Protein	Name
NM_201270.1	NP_958427.1	interleukin-4 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to mercury ion	IEP IEP: Inferred from expression pattern	7657819	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	19617880	RGD
involved in microglial cell activation	IDA IDA: Inferred from direct assay	23786632	RGD
involved in negative regulation of acute inflammatory response	IDA IDA: Inferred from direct assay	17250684	RGD
involved in negative regulation of chronic inflammatory response	IDA IDA: Inferred from direct assay	16869003	RGD
involved in negative regulation of macrophage activation	IMP IMP: Inferred from mutant phenotype	20623539	RGD
involved in negative regulation of nitric oxide biosynthetic process	IDA IDA: Inferred from direct assay	18182309	RGD
involved in neuroinflammatory response	IDA IDA: Inferred from direct assay	27235345	RGD
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11572871	RGD
involved in positive regulation of amyloid-beta clearance	IDA IDA: Inferred from direct assay	18941241	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	17125592	RGD
involved in positive regulation of defense response to virus by host	IDA IDA: Inferred from direct assay	9721086	RGD
involved in positive regulation of eosinophil chemotaxis	IDA IDA: Inferred from direct assay	11071660	RGD
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	18941241	RGD
involved in positive regulation of interleukin-10 production	IDA IDA: Inferred from direct assay	17125592	RGD
involved in positive regulation of mononuclear cell migration	IDA IDA: Inferred from direct assay	11071660	RGD
involved in positive regulation of reactive oxygen species biosynthetic process	IDA IDA: Inferred from direct assay	24073824	RGD
involved in positive regulation of receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	18941241	RGD
involved in regulation of proton transport	IDA IDA: Inferred from direct assay	11739109	RGD
involved in response to cytokine	IEP IEP: Inferred from expression pattern	18231731	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	20116195	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	19608731	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	18499367	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18953683	RGD
involved in retina development in camera-type eye	IEP IEP: Inferred from expression pattern	23070471	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	18557728	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il4 Protein Structure

IL4_13

0
100
147 a.a.

Protein Preferred Names

Protein Names

interleukin-4

B-cell IGG differentiation factor	B-cell growth factor 1
B-cell stimulatory factor 1	BSF-1
IL-4	lymphocyte stimulatory factor 1

Related Agents

Approval

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0539	Desloratadine		99.83%	Yes
HY-108013	Armillarisin A		99.80%	Unkown
HY-B0446	Naphazoline hydrochloride		98.12%	Unkown
HY-17002	Suplatast (Tosilate)	Inhibitor	98.33%	Unkown
HY-111326A	Naphazoline nitrate		≥98.0%	Unkown
HY-B0010C	(S,S)-Formoterol	Activator	/	Unkown
HY-111326	Naphazoline		/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9926	Dupilumab	Inhibitor	≥99.2%	Unkown
HY-P99025	Lebrikizumab	Inhibitor	99.90%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-144683	PF-07038124	Inhibitor	/	Phase 2

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990093	Stapokibart	Inhibitor	96.34%	Phase 3
HY-P990090	Rademikibart	Inhibitor	/	Phase 3
HY-P99724	Manfidokimab		95.00%	Phase 2
HY-P99883	Romilkimab		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (28)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-126360	Oxazolone		≥98.0%	Unkown
HY-134771	YM-341619	Inhibitor	99.06%	Unkown
HY-139092	IL-4-inhibitor-1	Inhibitor	98.14%	Unkown
HY-N3312	Matairesinol		98.33%	Unkown
HY-N0600	Ginsenoside F3	Modulator	99.84%	Unkown
HY-N2426	Clerodendrin	Inhibitor	99.66%	Unkown
HY-N7652	Terminolic acid	Inhibitor	99.63%	Unkown
HY-141582	Ceramide 3		≥98.0%	Unkown
HY-125019	iJak-381	Inhibitor	99.86%	Unkown
HY-15131	PNRI-299	Inhibitor	/	Unkown
HY-116609	C6 L-threo Ceramide	Inhibitor	/	Unkown
HY-144683A	PF-07038124 hydrochloride	Inhibitor	/	Unkown
HY-144684	PDE4-IN-8	Inhibitor	/	Unkown
HY-155951	JAK3-IN-14	Inhibitor	99.32%	Unkown
HY-162248	JAK1/2-IN-1	Inhibitor	/	Unkown
HY-162404	Smad2/3-IN-2	Inhibitor	/	Unkown
HY-162405	Smad2/3-IN-1	Inhibitor	/	Unkown
HY-162726	GCS-11	Activator	/	Unkown
HY-162727	GCS-12		/	Unkown
HY-163670	TLR7 agonist 21	Inhibitor	/	Unkown
HY-163704	KRN7000 analog 1		/	Unkown
HY-165484	AVP-13358	Inhibitor	/	Unkown
HY-RS06765	IL4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06766	Il4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06767	Il4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06768	IL4I1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06769	IL4R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-124613	Pyrazinib	Inhibitor	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990708	Bizaxofusp		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il4	NCBI	NCBI:3565
Macaca fascicularis	Il4	NCBI	NCBI:107130068
Mus musculus	Il4	NCBI	NCBI:16189
Susscrofa domestica	Il4	NCBI
Macaca mulatta	Il4	NCBI	NCBI:574281

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