Il4 - interleukin 4 Gene

Mus musculus

Also known as Il-4; BSF-1

Gene ID: 16189 | Gene type: protein coding

About Il4

Chromosome 11: 53,493,809-53,509,496 reverse strand.GRCm39:CM001004.3

This gene has 4 transcripts (splice variants), 92 orthologues and is associated with 61 phenotypes. Low expression observed in reference dataset.

Summary

Enables cytokine activity. Involved in several processes, including innate immune response in mucosa; negative regulation of white fat cell proliferation; and regulation of gene expression. Acts upstream of or within several processes, including T-helper cell differentiation; positive regulation of macromolecule metabolic process; and regulation of leukocyte activation. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; colon; hemolymphoid system; liver; and placenta. Used to study Sjogren's syndrome; atopic dermatitis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic Cancer (multiple). Orthologous to human IL4 (interleukin 4). [provided by Alliance of Genome Resources, Apr 2022]

Il4 Products(1)

mRNA	Protein	Name
NM_021283.2	NP_067258.1	interleukin-4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	1588041	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of B cell activation	IDA IDA: Inferred from direct assay	8566034	MGI
acts upstream of or within B cell costimulation	IDA IDA: Inferred from direct assay	18762567	MGI
acts upstream of B cell proliferation	IDA IDA: Inferred from direct assay	10979977	MGI
acts upstream of MHC class II biosynthetic process	IDA IDA: Inferred from direct assay	10549626	MGI
acts upstream of T cell proliferation	IDA IDA: Inferred from direct assay	1588041	MGI
acts upstream of or within T-helper 1 cell lineage commitment	IGI IGI: Inferred from genetic interaction	20706986	MGI
acts upstream of or within T-helper 2 cell differentiation	IDA IDA: Inferred from direct assay	20706986	MGI
acts upstream of activated T cell proliferation	IDA IDA: Inferred from direct assay	9841920	MGI
involved in cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	11971948	MGI
acts upstream of or within defense response to protozoan	IMP IMP: Inferred from mutant phenotype	7927664	MGI
acts upstream of extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	10429671	MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	12115603	MGI
involved in innate immune response in mucosa	IDA IDA: Inferred from direct assay	9973465	MGI
acts upstream of isotype switching to IgE isotypes	IDA IDA: Inferred from direct assay	14988498	MGI
acts upstream of isotype switching to IgG isotypes	IDA IDA: Inferred from direct assay	14988498	MGI
acts upstream of or within negative regulation of T cell activation	IDA IDA: Inferred from direct assay	18997793	MGI
acts upstream of or within negative regulation of T-helper 17 cell differentiation	IDA IDA: Inferred from direct assay	18792410	MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	10429671	MGI
acts upstream of or within negative regulation of osteoclast differentiation	IDA IDA: Inferred from direct assay	12941478	MGI
involved in negative regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	29061364	MGI
involved in negative regulation of white fat cell proliferation	IDA IDA: Inferred from direct assay	24347527	MGI
acts upstream of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	8022486	MGI
involved in positive regulation of ATP biosynthetic process	IDA IDA: Inferred from direct assay	29061364	MGI
acts upstream of or within positive regulation of B cell activation	IDA IDA: Inferred from direct assay	8566034	MGI
acts upstream of or within positive regulation of B cell proliferation	IDA IDA: Inferred from direct assay	10979977	MGI
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	7749983	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	7749983	MGI
acts upstream of or within positive regulation of MHC class II biosynthetic process	IDA IDA: Inferred from direct assay	10549626	MGI
acts upstream of or within positive regulation of T cell proliferation	IDA IDA: Inferred from direct assay	1588041	MGI
acts upstream of or within positive regulation of activated T cell proliferation	IDA IDA: Inferred from direct assay	9841920	MGI
involved in positive regulation of amyloid-beta clearance	IDA IDA: Inferred from direct assay	18941241	MGI
involved in positive regulation of cellular respiration	IDA IDA: Inferred from direct assay	29061364	MGI
involved in positive regulation of chemokine production	IDA IDA: Inferred from direct assay	9013979	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	24906148	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	29061364	MGI
acts upstream of or within positive regulation of immunoglobulin production	IGI IGI: Inferred from genetic interaction	15944273	MGI
acts upstream of or within positive regulation of immunoglobulin production	IMP IMP: Inferred from mutant phenotype	15944273	MGI
acts upstream of or within positive regulation of isotype switching to IgE isotypes	IDA IDA: Inferred from direct assay	14988498	MGI
acts upstream of or within positive regulation of isotype switching to IgG isotypes	IDA IDA: Inferred from direct assay	12882831	MGI
involved in positive regulation of macroautophagy	IDA IDA: Inferred from direct assay	26416964	MGI
acts upstream of or within positive regulation of mast cell degranulation	IGI IGI: Inferred from genetic interaction	15944273	MGI
acts upstream of or within positive regulation of mast cell degranulation	IMP IMP: Inferred from mutant phenotype	15944273	MGI
acts upstream of or within positive regulation of myoblast fusion	IDA IDA: Inferred from direct assay	12757709	MGI
acts upstream of or within positive regulation of myoblast fusion	IMP IMP: Inferred from mutant phenotype	12757709	MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	8022486	MGI
acts upstream of or within positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	12115603	MGI
involved in positive regulation of receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	18941241	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1588041	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15187136	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	9110977	MGI
acts upstream of or within positive regulation of tyrosine phosphorylation of STAT protein	IDA IDA: Inferred from direct assay	10485657	MGI
acts upstream of or within regulation of immune response	IDA IDA: Inferred from direct assay	12882831	MGI
acts upstream of or within response to nematode	IDA IDA: Inferred from direct assay	26644468	MGI
acts upstream of or within response to selenium ion	IDA IDA: Inferred from direct assay	26644468	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1588041	MGI
acts upstream of tyrosine phosphorylation of STAT protein	IDA IDA: Inferred from direct assay	10485657	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	19666510	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	11057672	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il4 Protein Structure

IL4_13

0
100
140 a.a.

Protein Preferred Names

Protein Names

interleukin-4

B-cell IgG differentiation factor	B-cell growth factor 1
B-cell stimulatory factor 1	IGG1 induction factor
lymphocyte stimulatory factor 1

Recombinant Il4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7080	IL-4 Protein, Mouse (CHO)	P07750 (H21-S140)	≥95%
HY-P70644	IL-4 Protein, Mouse	P07750 (H23-S140)	≥95%
HY-P70653	IL-4 Protein, Mouse (HEK293, His)	P07750 (H21-S140)	≥95%
HY-P73215	IL-4 Protein, Mouse (Q136D, Y139D, sf9, His)	P07750 (H21-S140, Q136D, Y139D)	≥95%
HY-P700214AF	Animal-Free IL-4 Protein, Mouse (His)	P07750 (H21-S140)	≥95%
HY-P701093	IL-4 Protein, Mouse (HEK293)	P07750 (H21-S140)	≥95%

Related Agents

Approval

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0539	Desloratadine		99.83%	Yes
HY-108013	Armillarisin A		99.80%	Unkown
HY-B0446	Naphazoline hydrochloride		98.12%	Unkown
HY-17002	Suplatast (Tosilate)	Inhibitor	98.33%	Unkown
HY-111326A	Naphazoline nitrate		≥98.0%	Unkown
HY-B0010C	(S,S)-Formoterol	Activator	/	Unkown
HY-111326	Naphazoline		/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9926	Dupilumab	Inhibitor	≥99.2%	Unkown
HY-P99025	Lebrikizumab	Inhibitor	99.90%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-144683	PF-07038124	Inhibitor	/	Phase 2

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990093	Stapokibart	Inhibitor	96.34%	Phase 3
HY-P990090	Rademikibart	Inhibitor	/	Phase 3
HY-P99724	Manfidokimab		95.00%	Phase 2
HY-P99883	Romilkimab		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (29)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-126360	Oxazolone		≥98.0%	Unkown
HY-139092	IL-4-inhibitor-1	Inhibitor	98.14%	Unkown
HY-134771	YM-341619	Inhibitor	99.06%	Unkown
HY-N0600	Ginsenoside F3	Modulator	99.84%	Unkown
HY-N3312	Matairesinol		98.33%	Unkown
HY-N2426	Clerodendrin	Inhibitor	99.66%	Unkown
HY-N7652	Terminolic acid	Inhibitor	99.63%	Unkown
HY-141582	Ceramide 3		≥98.0%	Unkown
HY-125019	iJak-381	Inhibitor	99.86%	Unkown
HY-15131	PNRI-299	Inhibitor	/	Unkown
HY-116609	C6 L-threo Ceramide	Inhibitor	/	Unkown
HY-144683A	PF-07038124 hydrochloride	Inhibitor	/	Unkown
HY-144684	PDE4-IN-8	Inhibitor	/	Unkown
HY-155951	JAK3-IN-14	Inhibitor	99.32%	Unkown
HY-162248	JAK1/2-IN-1	Inhibitor	/	Unkown
HY-162404	Smad2/3-IN-2	Inhibitor	/	Unkown
HY-162405	Smad2/3-IN-1	Inhibitor	/	Unkown
HY-162726	GCS-11	Activator	/	Unkown
HY-162727	GCS-12		/	Unkown
HY-163670	TLR7 agonist 21	Inhibitor	/	Unkown
HY-163704	KRN7000 analog 1		/	Unkown
HY-165484	AVP-13358	Inhibitor	/	Unkown
HY-RS06765	IL4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06766	Il4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06767	Il4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06768	IL4I1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06769	IL4R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-124613	Pyrazinib	Inhibitor	/	Unkown
HY-141582S	Ceramide 3-d3		/	Unkown

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990708	Bizaxofusp		/	Unkown
HY-P990910	Comekibart	Inhibitor	/	Unkown
HY-P990983	Drotokibart	Inhibitor	/	Unkown
HY-P991031	Telikibart	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il4	NCBI	NCBI:3565
Macaca fascicularis	Il4	NCBI	NCBI:107130068
Susscrofa domestica	Il4	NCBI
Rattus norvegicus	Il4	NCBI	NCBI:287287
Macaca mulatta	Il4	NCBI	NCBI:574281

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