2. Gene
  3. Sirt3 - sirtuin 3 Gene

Sirt3 - sirtuin 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 293615 | Gene type: protein coding

About Sirt3

Primary_assembly 1: 195,942,073-195,964,808 reverse strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 198 orthologues, 6 paralogues and is associated with 13 phenotypes. Biased expression in Liver (RPKM 142.2), Adrenal (RPKM 122.2) and 9 other tissues.

Summary

Enables Enzyme binding activity. Involved in several processes, including negative regulation of ERK1 and ERK2 cascade; negative regulation of Reactive Oxygen Species metabolic process; and positive regulation of Insulin secretion. Located in mitochondrion. Used to study non-alcoholic fatty liver disease. Biomarker of congestive heart failure; myocardial infarction; obesity; and prediabetes syndrome. Orthologous to human SIRT3 (Sirtuin 3). [provided by Alliance of Genome Resources, Apr 2022]

Sirt3 Products(1)

mRNA Protein Name
NM_001106313.2 NP_001099783.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
24505357 RGD
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
23397292 RGD
involved in negative regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
23397292 RGD
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
23397292 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sirt3 Protein Structure

SIRT1

SIRT1: cd01408 (73 - 307)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

NAD-dependent protein deacetylase sirtuin-3, mitochondrial

SIRT3L mitochondrial

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0130A Perindopril erbumine 99.98% Yes
HY-B0130 Perindopril 98.01% Yes
Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-123033A Nicotinamide riboside chloride Activator 99.90% Phase 4
HY-123033 Nicotinamide riboside Activator / Phase 4
HY-123033C Nicotinamide riboside malate Activator / Phase 4
HY-123033B Nicotinamide riboside tartrate Activator / Phase 4
Pre-clinical Phase
Bioactive Molecules (26)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108331 3-TYP Inhibitor 99.96% Unkown
HY-100578 AGK2 Inhibitor 99.62% Unkown
HY-N1511 Ganoderic acid D Activator 99.40% Unkown
HY-15510 Tenovin-6 Inhibitor 98.33% Unkown
HY-136199 SIRT1-IN-1 Inhibitor 98.19% Unkown
HY-16616 SIRT-IN-2 Inhibitor 98.08% Unkown
HY-15510B Tenovin-6 Hydrochloride Inhibitor 98.88% Unkown
HY-N6675 Gardenia yellow Activator / Unkown
HY-N2673 5-Heptadecylresorcinol Activator 99.83% Unkown
HY-151519 SIRT2-IN-9 Inhibitor 99.45% Unkown
HY-16615 SIRT-IN-1 Inhibitor 98.58% Unkown
HY-163987 SIRT3 activator 2 Activator / Unkown
HY-111329 JGB1741 Inhibitor 99.05% Unkown
HY-111303 CHIC35 Inhibitor / Unkown
HY-155784 SPC-180002 Inhibitor / Unkown
HY-146013 Sirt1/2-IN-1 Inhibitor / Unkown
HY-170402 SIRT6-IN-4 Inhibitor / Unkown
HY-124946 C1A Inhibitor / Unkown
HY-161920 SIRT3-IN-1 Inhibitor / Unkown
HY-118343 AC-93253 Inhibitor / Unkown
HY-160944 hsa62 Inhibitor / Unkown
HY-114906 SIRT1/2/3-IN-2 Inhibitor / Unkown
HY-160617 SIRT2-IN-14 Inhibitor / Unkown
HY-150727 SIRT5 inhibitor 4 Inhibitor / Unkown
HY-118109 SIRT3-IN-2 Inhibitor / Unkown
HY-W109401 SIRT-IN-6 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sirt3 NCBI NCBI:23410
Mus musculus Sirt3 NCBI NCBI:64384