SIRT3 - sirtuin 3 Gene

Homo sapiens

Also known as SIR2L3

Gene ID: 23410 | Gene type: protein coding

About SIRT3

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:215,030-236,931 (from NCBI)

This gene has 16 transcripts (splice variants), 198 orthologues and 6 paralogues. Ubiquitous expression in testis (RPKM 6.7), brain (RPKM 5.6) and 25 other tissues.

Summary

SIRT3 encodes a member of the Sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate Reactive Oxygen Species, inhibit Apoptosis, and prevent the formation of Cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, Cancer, Cardiovascular Disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019]

SIRT3 Products(38)

mRNA	Protein	Name
NR_163402.1
NM_001370316.1	NP_001357245.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform g precursor
NR_163388.1
NR_163400.1
NR_163395.1
NM_001370317.1	NP_001357246.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform h
NR_163386.1
XM_011519957.3	XP_011518259.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X1
NR_163387.1
NR_163392.1
NR_163396.1
NR_163391.1
NM_001370310.1	NP_001357239.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform c
NR_163390.1
NR_163394.1
NM_001017524.3	NP_001017524.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform b
NR_163398.1
NM_001370325.1	NP_001357254.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform j
XR_007062467.1
NM_001370312.1	NP_001357241.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform d
NM_001370319.1	NP_001357248.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform b
XM_017017431.2	XP_016872920.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X1
NM_001370320.1	NP_001357249.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform b
NR_163401.1
NR_163393.1
NR_163399.1
NM_001370318.1	NP_001357247.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform b
NM_001370324.1	NP_001357253.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform j
XM_011519956.3	XP_011518258.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X1
NM_001370323.1	NP_001357252.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform i
NR_163397.1
NM_012239.6	NP_036371.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform a
NM_001370322.1	NP_001357251.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform i
NM_001370321.1	NP_001357250.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform i
NR_163389.1
NM_001370314.1	NP_001357243.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform e
NM_001370315.1	NP_001357244.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform f precursor
XM_047426677.1	XP_047282633.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16788062	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	29445193	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	19535340	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in aerobic respiration	IMP IMP: Inferred from mutant phenotype	22309213	GOA
involved in peptidyl-lysine deacetylation	IMP IMP: Inferred from mutant phenotype	22309213	GOA
involved in positive regulation of catalase activity	IDA IDA: Inferred from direct assay	25210848	GOA
involved in positive regulation of superoxide dismutase activity	IDA IDA: Inferred from direct assay	25210848	GOA
involved in protein deacetylation	IDA IDA: Inferred from direct assay	16788062	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	12186850	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	16079181	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	23283301	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIRT3 Protein Structure

SIR2

0
100
200
300
399 a.a.

Protein Preferred Names

Protein Names

NAD-dependent protein deacetylase sirtuin-3, mitochondrial

NAD-dependent deacetylase sirtuin-3, mitochondrial	SIR2-like protein 3
mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase	regulatory protein SIR2 homolog 3
silent mating type information regulation 2, S.cerevisiae, homolog 3	sir2-like 3
sirtuin type 3

SIRT3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SIRT3	Q9NTG7	OPA1	Homo sapiens	O60313	Anti Tag CoIP	24344202
Intra	SIRT3	Q9NTG7	OPA1	Homo sapiens	O60313	Pull Down	24344202
Intra	SIRT3	Q9NTG7	ATP5F1A	Homo sapiens	P25705	Pull Down	19343720
Intra	SIRT3	Q9NTG7	ATP5F1A	Homo sapiens	P25705	Anti Tag CoIP	19343720

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Monckeberg Arteriosclerosis

Monckeberg Medial Calcific Sclerosis

Diabetes Mellitus

Diabetes

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
BMIQ11	Obesity Bmiq11
Obesity, Early-Onset	Obesity , Susceptibility To
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Diabetes Mellitus, Non-Insulin-Dependent	Type 2 Diabetes
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Protection Against	Lung Cancer, Susceptibility To
Adenocarcinoma Of Lung, Somatic	Nonsmall Cell Lung Cancer
Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Aging

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency	Nadh:Q(1) Oxidoreductase Deficiency
MC1DN1	Nadh-Coenzyme Q Reductase Deficiency
Isolated Mitochondrial Respiratory Chain Complex I Deficiency	Isolated Nadh-Coenzyme Q Reductase Deficiency
Isolated Nadh-Coq Reductase Deficiency	Isolated Nadh-Ubiquinone Reductase Deficiency
Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of	Nuclear Type Mitochondrial Complex I Deficiency 1
Isolated Complex I Deficiency	Complex 1 Mitochondrial Respiratory Chain Deficiency
Nadh Coenzyme Q Reductase Deficiency	Complex I Mitochondrial Respiratory Chain Deficiency
Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I	Nadh:Ubiquinone Oxidoreductase Deficiency
Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Non-Alcoholic Fatty Liver Disease

Fatty Liver	Non-Alcoholic Fatty Liver
Nafld	Nonalcoholic Fatty Liver Disease
Nonalcoholic Steatohepatitis	Steatosis
Nafl	Nash
Non-Alcoholic Steatohepatitis	Susceptibility To Nonalcoholic Fatty Liver Disease
Steatohepatitis	Fatty Degeneration
Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis	Nafld Without Nash
Nafld Without Mention Of Nash

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0130A	Perindopril erbumine		99.98%	Yes
HY-B0130	Perindopril		98.01%	Yes

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-123033A	Nicotinamide riboside chloride	Activator	99.90%	Phase 4
HY-123033	Nicotinamide riboside	Activator	/	Phase 4
HY-123033B	Nicotinamide riboside tartrate	Activator	/	Phase 4
HY-123033C	Nicotinamide riboside malate	Activator	/	Phase 4

Pre-clinical Phase

Bioactive Molecules (22)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108331	3-TYP	Inhibitor	99.96%	Unkown
HY-100578	AGK2	Inhibitor	99.62%	Unkown
HY-N1511	Ganoderic acid D	Activator	99.81%	Unkown
HY-15510	Tenovin-6	Inhibitor	98.33%	Unkown
HY-136199	SIRT1-IN-1	Inhibitor	98.19%	Unkown
HY-16616	SIRT-IN-2	Inhibitor	98.08%	Unkown
HY-N6675	Gardenia yellow	Activator	/	Unkown
HY-15510B	Tenovin-6 Hydrochloride	Inhibitor	98.88%	Unkown
HY-151519	SIRT2-IN-9	Inhibitor	99.45%	Unkown
HY-N2673	5-Heptadecylresorcinol	Activator	99.83%	Unkown
HY-16615	SIRT-IN-1	Inhibitor	98.58%	Unkown
HY-111329	JGB1741	Inhibitor	99.05%	Unkown
HY-111303	CHIC35	Inhibitor	/	Unkown
HY-155784	SPC-180002	Inhibitor	/	Unkown
HY-163987	SIRT3 activator 2	Activator	/	Unkown
HY-160617	SIRT2-IN-14	Inhibitor	/	Unkown
HY-124946	C1A	Inhibitor	/	Unkown
HY-118343	AC-93253	Inhibitor	/	Unkown
HY-160944	hsa62	Inhibitor	/	Unkown
HY-146013	Sirt1/2-IN-1	Inhibitor	/	Unkown
HY-150727	SIRT5 inhibitor 4	Inhibitor	/	Unkown
HY-161920	SIRT3-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SIRT3	VGNC	VGNC:46184
Felis catus	SIRT3	VGNC	VGNC:65157
Rattus norvegicus	SIRT3	RGD	RGD:1308374
Bos taurus	SIRT3	VGNC	VGNC:34632
Macaca mulatta	SIRT3	VGNC	VGNC:77234
Mus musculus	SIRT3	MGD	MGI:1927665
Others	SIRT3	NCBI

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