2. Gene
  3. Sirt3 - sirtuin 3 Gene

Sirt3 - sirtuin 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Sir2l3; 2310003L23Rik

Gene ID: 64384 | Gene type: protein coding

About Sirt3

Chromosome 7: 140,443,579-140,462,222 reverse strand.GRCm39:CM001000.3

This gene has 10 transcripts (splice variants), 198 orthologues, 6 paralogues and is associated with 36 phenotypes. Ubiquitous expression in kidney adult (RPKM 35.3), liver adult (RPKM 33.7) and 28 other tissues.

Summary

Enables NAD-dependent histone deacetylase activity (H3-K14 specific) and sequence-specific DNA binding activity. Involved in peptidyl-lysine deacetylation; positive regulation of ceramide biosynthetic process; and positive regulation of mitochondrial transcription. Acts upstream of or within negative regulation of peptidyl-lysine acetylation and protein deacetylation. Located in mitochondrial inner membrane and mitochondrial matrix. Part of protein-containing complex. Is expressed in several structures, including brain; branchial arch; endocrine gland; genitourinary system; and liver and biliary system. Used to study abdominal obesity-metabolic syndrome. Orthologous to human SIRT3 (Sirtuin 3). [provided by Alliance of Genome Resources, Apr 2022]

Sirt3 Products(3)

mRNA Protein Name
NM_022433.2 NP_071878.2 NAD-dependent protein deacetylase sirtuin-3 isoform 1
NM_001177804.1 NP_001171275.1 NAD-dependent protein deacetylase sirtuin-3 isoform 3
NM_001127351.1 NP_001120823.1 NAD-dependent protein deacetylase sirtuin-3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables NAD-dependent protein lysine deacetylase activity IDA
IDA: Inferred from direct assay
16790548 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21720390 MGI
enables protein lysine deacetylase activity IDA
IDA: Inferred from direct assay
21858060 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23283301 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of peptidyl-lysine acetylation IDA
IDA: Inferred from direct assay
17923681 MGI
acts upstream of or within negative regulation of peptidyl-lysine acetylation IMP
IMP: Inferred from mutant phenotype
17923681 MGI
involved in peptidyl-lysine deacetylation IDA
IDA: Inferred from direct assay
26620563 MGI
involved in positive regulation of ceramide biosynthetic process IDA
IDA: Inferred from direct assay
26620563 MGI
involved in positive regulation of mitochondrial transcription IMP
IMP: Inferred from mutant phenotype
23283301 MGI
acts upstream of or within protein deacetylation IMP
IMP: Inferred from mutant phenotype
23576753 MGI
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
11056054 MGI
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
18054327 MGI
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
17923681 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
17923681 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
23283301 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sirt3 Protein Structure

SIRT1

SIRT1: cd01408 (0 - 230)

  • 0
  • 100
  • 200
  • 257 a.a.
Protein Preferred Names Protein Names

NAD-dependent protein deacetylase sirtuin-3

NAD-dependent deacetylase sirtuin-3

SIR2-like protein 3

SIRT3L mitochondrial

mSIR2L3

mitochondrial protein lysine deacetylase

regulatory protein SIR2 homolog 3

silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3

Sirt3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Sirt3 Q8R104 Aldh2 Mus musculus P47738
Anti Bait CoIP
21720390
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0130A Perindopril erbumine 99.98% Yes
HY-B0130 Perindopril 98.01% Yes
Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-123033A Nicotinamide riboside chloride Activator 99.90% Phase 4
HY-123033 Nicotinamide riboside Activator / Phase 4
HY-123033B Nicotinamide riboside tartrate Activator / Phase 4
HY-123033C Nicotinamide riboside malate Activator / Phase 4
Pre-clinical Phase
Bioactive Molecules (22)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108331 3-TYP Inhibitor 99.96% Unkown
HY-100578 AGK2 Inhibitor 99.62% Unkown
HY-N1511 Ganoderic acid D Activator 99.81% Unkown
HY-15510 Tenovin-6 Inhibitor 98.33% Unkown
HY-136199 SIRT1-IN-1 Inhibitor 98.19% Unkown
HY-16616 SIRT-IN-2 Inhibitor 98.08% Unkown
HY-N6675 Gardenia yellow Activator / Unkown
HY-15510B Tenovin-6 Hydrochloride Inhibitor 98.88% Unkown
HY-151519 SIRT2-IN-9 Inhibitor 99.45% Unkown
HY-N2673 5-Heptadecylresorcinol Activator 99.83% Unkown
HY-16615 SIRT-IN-1 Inhibitor 98.58% Unkown
HY-111329 JGB1741 Inhibitor 99.05% Unkown
HY-111303 CHIC35 Inhibitor / Unkown
HY-155784 SPC-180002 Inhibitor / Unkown
HY-163987 SIRT3 activator 2 Activator / Unkown
HY-160617 SIRT2-IN-14 Inhibitor / Unkown
HY-124946 C1A Inhibitor / Unkown
HY-118343 AC-93253 Inhibitor / Unkown
HY-160944 hsa62 Inhibitor / Unkown
HY-146013 Sirt1/2-IN-1 Inhibitor / Unkown
HY-150727 SIRT5 inhibitor 4 Inhibitor / Unkown
HY-161920 SIRT3-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sirt3 NCBI NCBI:23410