Bace1 - beta-secretase 1 Gene

Rattus norvegicus

Also known as Bace

Gene ID: 29392 | Gene type: protein coding

About Bace1

Primary_assembly 8: 46,142,116-46,165,876 forward strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 219 orthologues, 8 paralogues and is associated with 22 phenotypes. Biased expression in Brain (RPKM 222.4), Heart (RPKM 151.3) and 9 other tissues.

Summary

Enables peptidase activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to metal ion; and detection of mechanical stimulus involved in sensory perception of pain. Located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and neuronal cell body. Used to study dementia. Biomarker of Alzheimer's disease; sensory peripheral neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE1 (Beta-secretase 1). [provided by Alliance of Genome Resources, Apr 2022]

Bace1 Products(1)

mRNA	Protein	Name
NM_019204.2	NP_062077.1	beta-secretase 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables peptidase activity	IDA IDA: Inferred from direct assay	10531052	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in amyloid-beta metabolic process	IMP IMP: Inferred from mutant phenotype	10531052	RGD
involved in cellular response to amyloid-beta	IEP IEP: Inferred from expression pattern	26984601	RGD
involved in cellular response to copper ion	IEP IEP: Inferred from expression pattern	18583042	RGD
involved in cellular response to manganese ion	IEP IEP: Inferred from expression pattern	18583042	RGD
involved in detection of mechanical stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	28012171	RGD
involved in prepulse inhibition	IMP IMP: Inferred from mutant phenotype	28281673	RGD
involved in response to lead ion	IEP IEP: Inferred from expression pattern	29908845	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	26552445	RGD
located in dendrite	IDA IDA: Inferred from direct assay	26552445	RGD
located in endosome	IDA IDA: Inferred from direct assay	10531052	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	26552445	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	26296617	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bace1 Protein Structure

beta_secretase_like

0
100
200
300
400
501 a.a.

Protein Preferred Names

Protein Names

beta-secretase 1

ASP2	asp 2
aspartyl protease 2	beta-site APP cleaving enzyme 1
beta-site amyloid precursor protein cleaving enzyme 1	memapsin-2
membrane-associated aspartic protease 2

Related Agents

Clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16759	Verubecestat	Inhibitor	99.56%	Phase 3
HY-100740	Lanabecestat	Inhibitor	99.67%	Phase 3
HY-13240	LY2886721	Inhibitor	99.74%	Phase 2
HY-114245	Se-Methylselenocysteine	Inhibitor	≥98.0%	Phase 1
HY-10472	LY2811376	Inhibitor	99.89%	Phase 1
HY-109052	Atabecestat	Inhibitor	99.77%	Phase 1
HY-13438	AZD3839 free base	Inhibitor	99.91%	Phase 1
HY-100182	BACE1-IN-1	Inhibitor	99.02%	Phase 1

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0226A	Epiberberine chloride	Inhibitor	99.02%	Unkown
HY-15908	BCA	Inhibitor	99.76%	Unkown
HY-136742	BACE2-IN-1	Inhibitor	99.4%	Unkown
HY-N1255	Scoulerine	Inhibitor	99.27%	Unkown
HY-100740C	(1α,1'S,4β)-Lanabecestat	Inhibitor	96.01%	Unkown
HY-111383	LX2343	Inhibitor	99.80%	Unkown
HY-N2284	Sophoflavescenol	Inhibitor	98.15%	Unkown
HY-N0226	Epiberberine	Inhibitor	98.46%	Unkown
HY-128594	BACE1-IN-4	Inhibitor	/	Unkown
HY-112444	BACE1-IN-2	Inhibitor	/	Unkown
HY-128774	AM-6494	Inhibitor	/	Unkown
HY-130244	BACE1-IN-5	Inhibitor	/	Unkown
HY-12938	AMG-8718	Inhibitor	/	Unkown
HY-N2215	Aloeresin D	Inhibitor	99.69%	Unkown
HY-P2713	OM99-2	Inhibitor	/	Unkown
HY-149211	AChE/BChE-IN-12	Inhibitor	/	Unkown
HY-139720	β-Secretase Inhibitor III	Inhibitor	/	Unkown
HY-P3426	BACE1-IN-10	Inhibitor	/	Unkown
HY-151260	AChE/BACE1/GSK3β-IN-1	Inhibitor	/	Unkown
HY-161359	BACE1-IN-14	Inhibitor	/	Unkown
HY-122080	Memoquin	Inhibitor	/	Unkown
HY-144741	BACE1-IN-9	Inhibitor	/	Unkown
HY-151348	BACE1-IN-11	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bace1	NCBI	NCBI:23621
Mus musculus	Bace1	NCBI	NCBI:23821

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