2. Gene
  3. Irak4 - interleukin-1 receptor-associated kinase 4 Gene

Irak4 - interleukin-1 receptor-associated kinase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 300177 | Gene type: protein coding

About Irak4

Primary_assembly 7: 125,682,488-125,717,837 forward strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 202 orthologues, 4 paralogues and is associated with 8 phenotypes. Biased expression in Spleen (RPKM 52.5), Thymus (RPKM 38.7) and 9 other tissues.

Summary

Predicted to enable interleukin-1 receptor binding activity; protein kinase binding activity; and protein serine/threonine kinase activity. Involved in JNK cascade; cytokine-mediated signaling pathway; and positive regulation of smooth muscle cell proliferation. Located in extracellular space. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human IRAK4 (interleukin 1 receptor associated kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Irak4 Products(1)

mRNA Protein Name
NM_001106791.2 NP_001100261.2 interleukin-1 receptor-associated kinase 4
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in JNK cascade IMP
IMP: Inferred from mutant phenotype
15890643 RGD
involved in cytokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
15890643 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
15890643 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
23073793 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Irak4 Protein Structure

Death_IRAK4

Death_IRAK4: cd08793 (8 - 107)

STKc_IRAK4

STKc_IRAK4: cd14158 (171 - 457)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 461 a.a.
Protein Preferred Names Protein Names

interleukin-1 receptor-associated kinase 4

Related Agents

Clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-19836 Zimlovisertib Inhibitor 99.94% Phase 2
HY-135317 Emavusertib Inhibitor 99.94% Phase 2
HY-145483 KT-474 Inhibitor 99.27% Phase 2
HY-139374 Zabedosertib Inhibitor 98.14% Phase 2
HY-160487 KME-2780 Inhibitor 98.94% Phase 2
HY-109585 IRAK4-IN-7 Inhibitor 99.36% Phase 2
HY-135317B Emavusertib hydrochloride Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (44)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18992 AS2444697 Inhibitor 99.12% Unkown
HY-147141 HS-276 Inhibitor 98.59% Unkown
HY-111101 AZ1495 Inhibitor 98.07% Unkown
HY-153188 JNJ-1013 Degrader 99.80% Unkown
HY-134911 HS-243 Inhibitor 99.88% Unkown
HY-129966 PROTAC IRAK4 degrader-1 Inhibitor 99.72% Unkown
HY-148290 KTX-951 Degrader 98.03% Unkown
HY-123854 PF-06426779 Inhibitor 99.89% Unkown
HY-153224 GLPG2534 Inhibitor 98.73% Unkown
HY-135382A PROTAC IRAK4 degrader-3 Inhibitor 97.22% Unkown
HY-77048 IRAK-4 protein kinase inhibitor 2 Inhibitor 98.01% Unkown
HY-146112 IRAK4-IN-14 Inhibitor 99.01% Unkown
HY-13278A IRAK inhibitor 4 (trans) Inhibitor 99.02% Unkown
HY-131903 HS271 Inhibitor 99.92% Unkown
HY-150735 IRAK4-IN-20 Inhibitor 96.05% Unkown
HY-143231 IRAK4-IN-8 Inhibitor / Unkown
HY-150593 IRAK4-IN-16 Inhibitor / Unkown
HY-139317 PROTAC IRAK4 degrader-6 Inhibitor / Unkown
HY-148277 KTX-612 / Unkown
HY-139316 PROTAC IRAK4 degrader-5 Inhibitor / Unkown
HY-161620 DW18134 Inhibitor / Unkown
HY-150732 IRAK4-IN-18 Inhibitor / Unkown
HY-146073 IRAK4-IN-12 Inhibitor / Unkown
HY-148238 GNE-2256 Inhibitor / Unkown
HY-146111 IRAK4-IN-13 Inhibitor / Unkown
HY-150733 IRAK4-IN-19 Inhibitor / Unkown
HY-146072 IRAK4-IN-11 Inhibitor / Unkown
HY-139315 PROTAC IRAK4 degrader-4 Inhibitor / Unkown
HY-168611 PROTAC IRAK4 ligand-4 Degrader / Unkown
HY-162641 AF-45 Inhibitor / Unkown
HY-150594 IRAK4-IN-17 Inhibitor / Unkown
HY-135382 PROTAC IRAK4 degrader-2 Inhibitor / Unkown
HY-155574 IRAK4-IN-27 Inhibitor / Unkown
HY-146113 IRAK4-IN-15 Inhibitor / Unkown
HY-149345 IRAK4-IN-24 Inhibitor / Unkown
HY-148275 KTX-955 Inhibitor / Unkown
HY-160654 IRAK4 modulator-1 Modulator / Unkown
HY-148276 KTX-497 / Unkown
HY-143486 IRAK4-IN-10 Inhibitor / Unkown
HY-123956 HG-12-6 Inhibitor / Unkown
HY-159953 IRAK1/4/pan-FLT3 Kinase-IN-1 Inhibitor / Unkown
HY-143485 IRAK4-IN-9 Inhibitor / Unkown
HY-162359 BIO-7488 Inhibitor 99.44% Unkown
HY-158374 BIO-8169 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Irak4 NCBI NCBI:51135
Mus musculus Irak4 NCBI NCBI:266632