IFNGR2 - interferon gamma receptor 2 Gene

Homo sapiens

Also known as AF-1; IFGR2; IMD28; IFNGT1

Gene ID: 3460 | Gene type: protein coding

About IFNGR2

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:33,402,882-33,437,516 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 133 orthologues, 11 paralogues and is associated with 4 phenotypes. Ubiquitous expression in placenta (RPKM 30.0), appendix (RPKM 25.4) and 25 other tissues.

Summary

This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial Infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008]

IFNGR2 Products(2)

mRNA	Protein	Name
NM_001329128.2	NP_001316057.1	interferon gamma receptor 2 isoform 1 precursor
NM_005534.4	NP_005525.2	interferon gamma receptor 2 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables type II interferon receptor activity	IDA IDA: Inferred from direct assay	20015550	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in type III interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	20015550	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	20015550	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFNGR2 Protein Structure

Tissue_fac

Interfer-bind

0
100
200
300
337 a.a.

Protein Preferred Names

Protein Names

interferon gamma receptor 2

IFN-gamma receptor 2

IFNGR2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IFNGR2	P38484	RTP2	Homo sapiens	Q5QGT7	Validated Y2H	32296183
Intra	IFNGR2	P38484	ZDHHC24	Homo sapiens	Q6UX98	Validated Y2H	32296183
Intra	IFNGR2	P38484	TMEM199	Homo sapiens	Q8N511	Validated Y2H	32296183
Intra	IFNGR2	P38484	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
Intra	IFNGR2	P38484	ADIPOQ	Homo sapiens	Q15848	Validated Y2H	32296183
Intra	IFNGR2	P38484	ADIPOQ	Homo sapiens	Q15848	Y2H Array	32296183
Intra	IFNGR2	P38484	ERMP1	Homo sapiens	Q7Z2K6	Validated Y2H	32296183
Intra	IFNGR2	P38484	TMEM254	Homo sapiens	Q8TBM7	Validated Y2H	32296183
Intra	IFNGR2	P38484	CLEC7A	Homo sapiens	Q9BXN2-6	Validated Y2H	32296183
Intra	IFNGR2	P38484	TMEM97	Homo sapiens	Q5BJF2	Validated Y2H	32296183
Intra	IFNGR2	P38484	BRICD5	Homo sapiens	Q6PL45-2	Validated Y2H	32296183
Intra	IFNGR2	P38484	CLDN19	Homo sapiens	Q8N6F1-2	Validated Y2H	32296183
Intra	IFNGR2	P38484	SLC52A1	Homo sapiens	Q9NWF4	Validated Y2H	32296183
Intra	IFNGR2	P38484	CD302	Homo sapiens	Q8IX05	Validated Y2H	32296183
Intra	IFNGR2	P38484	TREX1	Homo sapiens	Q9NSU2-1	Validated Y2H	32296183
Intra	IFNGR2	P38484	BTNL8	Homo sapiens	Q6UX41-6	Validated Y2H	32296183
Intra	IFNGR2	P38484	TMEM140	Homo sapiens	Q9NV12	Validated Y2H	32296183
Intra	IFNGR2	P38484	PMP22	Homo sapiens	Q01453	Validated Y2H	32296183
Intra	IFNGR2	P38484	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	IFNGR2	P38484	EMP3	Homo sapiens	P54852	Validated Y2H	32296183
Intra	IFNGR2	P38484	CXCL9	Homo sapiens	Q07325	Validated Y2H	32296183
Intra	IFNGR2	P38484	GIMAP5	Homo sapiens	Q96F15	Validated Y2H	32296183
Intra	IFNGR2	P38484	SMIM3	Homo sapiens	Q9BZL3	Validated Y2H	32296183
Intra	IFNGR2	P38484	BNIP3	Homo sapiens	Q12983	Validated Y2H	32296183
Intra	IFNGR2	P38484	UNC50	Homo sapiens	Q53HI1	Validated Y2H	32296183
Intra	IFNGR2	P38484	INSIG2	Homo sapiens	Q9Y5U4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IFNGR2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7367	IFN-gamma R2 Protein, Human (CHO)	P38484 (S28-Q247)	≥95%

Related Diseases

Diseases

Alias

Immunodeficiency 28

IMD28	Ifngr2 Deficiency
Immunodeficiency 28, Mycobacteriosis, Autosomal Recessive	Immunodeficiency 28, Mycobacteriosis
Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar2 Deficiency	Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 2 Deficiency
Msmd Due To Complete Ifngammar2 Deficiency	Msmd Due To Complete Interferon Gamma Receptor 2 Deficiency
Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar2 Deficiency	Autosomal Recessive Msmd Due To Partial Ifngammar2 Deficiency
Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 2 Deficiency	Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 2 Deficiency
Immunodeficiency, Type 28, Mycobacteriosis

Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar2 Deficiency

Autosomal Dominant Msmd Due To Partial Ifngammar2 Deficiency	Autosomal Dominant Msmd Due To Partial Interferon Gamma Receptor 2 Deficiency
Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 2 Deficiency

Mycobacterium Abscessus

Tuberculous Salpingitis

Axillary Adenitis

Axillary Lymphadenitis

Immunodeficiency 27b

Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency	IMD27B
Immunodeficiency 27b, Mycobacteriosis, Autosomal Dominant	Ifngr1 Deficiency, Autosomal Dominant
Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency	Autosomal Dominant Msmd Due To Partial Ifngammar1 Deficiency
Autosomal Dominant Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency	Immunodeficiency 27b, Mycobacteriosis, Ad
Autosomal Dominant Ifngr1 Deficiency	Autosomal Dominant Immunodeficiency 27b, Mycobacteriosis
Immunodeficiency, Type 27b, Mycobacteriosis, Autosomal Dominant

Lepromatous Leprosy

Leprosy, Lepromatous	Type L Leprosy
Leprosy Lepromatous

Aneurysm, Intracranial Berry, 12

ANIB12

Intracranial Berry Aneurysm 12

Sezary'S Disease

Sezary Syndrome	Sézary Syndrome
Sezary'S Lymphoma	Sezary Disease
Sezary Erythroderma	Sezary Lymphoma

Silo Filler'S Disease

Silo Filler Disease

Silo-Fillers' Disease

Opportunistic Bacterial Infectious Disease

Nocardiosis

Nocardia Infection	Nocardia Infections
Nocardia Infectious Disease	Lung Nocardiosis
Nocardiasis	Nocardiosis Nos

Macs Syndrome

Macrocephaly, Alopecia, Cutis Laxa, And Scoliosis	Mycobacterium Avium Complex Disease
Rin2 Syndrome	Mycobacterium Avium-Intracellulare Infection
Tall Forehead, Sparse Hair, Skin Hyperextensibility, And Scoliosis	Mycobacterium Avium Complex
Mycobacterium Avium Infection	Infection Due To Mycobacterium Intracellulare
Mac Disease	Macrocephaly-Alopecia-Cutis Laxa-Scoliosis Syndrome
Rin2 Deficiency	Tall Forehead-Sparse Hair-Skin Hyperextensibility-Scoliosis Syndrome
MACS	Macrocephaly Alopecia Cutis Laxa And Scoliosis Syndrome

Immunodeficiency 21

Monocytopenia And Mycobacterial Infection Syndrome	Monomac
Gata2 Deficiency	Monocytopenia With Susceptibility To Infections
Dcml	IMD21
Dendritic Cell, Monocyte, B Lymphocyte, And Natural Killer Lymphocyte Deficiency	Monocytopenia With Susceptibility To Mycobacterial, Fungal, And Papillomavirus Infections And Myelodysplasia
Combined Immunodeficiency With Susceptibility To Mycobacterial, Viral, And Fungal Infections	Combined Immunodeficiency With Susceptibility To Mycobacterial, Viral And Fungal Infections
Dendritic Cell, Monocyte, B And Nk Lymphoid Deficiency	Monocyte-B-Natural Killer-Dendritic Cell Deficiency Syndrome
Monocytopenia With Mycobacterial, Fungal, And Papillomavirus Infections And Myelodysplasia	Combined Immunodeficiency With Mycobacterial, Viral, And Fungal Infections
Monocyte - B - Natural Killer - Dendritic Cell Deficiency	Combined Immunodeficiency With Susceptibility To Mycobacterial Viral And Fungal Infections
Dendritic Cell Monocyte Lymphocyte B And Natural Killer Lymphocyte Deficiency	Monocytopenia With Susceptibility To Mycobacterial Fungal And Papillomavirus Infections And Myelodysplasia

Sarcoidosis 1

Sarcoidosis	Boeck Sarcoid
Besnier-Boeck-Schaumann Disease	SS1
Sarcoidosis, Susceptibility To, 1	Lymphogranulomatosis
Hodgkin Disease	Boeck'S Disease
Boeck'S Sarcoid	Schaumann'S Disease Or Syndrome
Hutchinson-Boeck Disease Or Syndrome

Immunodeficiency 27a

IMD27A	Autosomal Recessive Ifngr1 Deficiency
Autosomal Recessive Immunodeficiency 27a, Mycobacteriosis	Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency
Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency	Autosomal Recessive Msmd Due To Partial Ifngammar1 Deficiency
Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency	Immunodeficiency 27a, Mycobacteriosis, Autosomal Recessive
Ifngr1 Deficiency, Autosomal Recessive	Immunodeficiency 27a, Mycobacteriosis, Ar
Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar1 Deficiency	Msmd Due To Complete Ifngammar1 Deficiency
Msmd Due To Complete Interferon Gamma Receptor 1 Deficiency	Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 1 Deficiency
Familial Disseminated Atypical Mycobacterial Infection	Interferon Gamma, Receptor 1, Deficiency
Immunodeficiency, Type 27a, Mycobacteriosis, Ar	Mycobacterial Disease, Mendelian Susceptibility To

Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous	Cmc
Candidiasis Chronic Mucocutaneous

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06589	IFNGR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IFNGR2	RGD	RGD:1307532
Macaca mulatta	IFNGR2	VGNC	VGNC:73569
Felis catus	IFNGR2	VGNC	VGNC:67706
Bos taurus	IFNGR2	VGNC	VGNC:30059
Mus musculus	IFNGR2	MGD	MGI:107654
Others	IFNGR2	NCBI

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