KRT81 - keratin 81 Gene

Homo sapiens

Also known as HB1; K81; Hb-1; KRTHB1; MLN137; ghHkb1; hHAKB2-1

Gene ID: 3887 | Gene type: protein coding

About KRT81

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,285,913-52,308,624 (from NCBI)

This gene has 1 transcript (splice variant), 46 orthologues, 68 paralogues and is associated with 3 phenotypes. Biased expression in placenta (RPKM 1.1), salivary gland (RPKM 0.5) and 13 other tissues.

Summary

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The Other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008]

KRT81 Products(1)

mRNA	Protein	Name
NM_002281.4	NP_002272.2	keratin, type II cuticular Hb1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT81 Protein Structure

Filament

0
100
200
300
400
505 a.a.

Protein Preferred Names

Protein Names

keratin, type II cuticular Hb1

hair keratin K2.9

KRT81 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KRT81	Q14533	KRT40	Homo sapiens	Q6A162	Validated Y2H	32296183
Intra	KRT81	Q14533	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	KRT81	Q14533	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	32296183
Intra	KRT81	Q14533	KRT40	Homo sapiens	Q6A162	Y2H Array	32296183
Intra	KRT81	Q14533	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	KRT81	Q14533	KRT37	Homo sapiens	O76014	Y2H Array	32296183
Intra	KRT81	Q14533	KRT37	Homo sapiens	O76014	Y2H Prey Pooling	32296183
Intra	KRT81	Q14533	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	KRT81	Q14533	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	KRT81	Q14533	KRT38	Homo sapiens	O76015	MAPPIT	25416956
Intra	KRT81	Q14533	KRT38	Homo sapiens	O76015	Y2H Array	32296183
Intra	KRT81	Q14533	KRT38	Homo sapiens	O76015	Y2H Prey Pooling	25416956
Intra	KRT81	Q14533	KRT38	Homo sapiens	O76015	Y2H Array	29892012
Intra	KRT81	Q14533	KRT38	Homo sapiens	O76015	Y2H Prey Pooling	32296183
Intra	KRT81	Q14533	KRT35	Homo sapiens	Q92764	Y2H Prey Pooling	32296183
Intra	KRT81	Q14533	KRT35	Homo sapiens	Q92764	Y2H Array	32296183
Intra	KRT81	Q14533	KRT35	Homo sapiens	Q92764	Validated Y2H	32296183
Intra	KRT81	Q14533	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	KRT81	Q14533	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	KRT81	Q14533	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	KRT81	Q14533	KRT39	Homo sapiens	Q6A163	Y2H Prey Pooling	32296183
Intra	KRT81	Q14533	KRT39	Homo sapiens	Q6A163	Validated Y2H	32296183
Intra	KRT81	Q14533	KRT39	Homo sapiens	Q6A163	Y2H Array	32296183
Intra	KRT81	Q14533	KRT28	Homo sapiens	Q7Z3Y7	Y2H Array	32296183
Intra	KRT81	Q14533	KRT28	Homo sapiens	Q7Z3Y7	Validated Y2H	32296183
Intra	KRT81	Q14533	KRT28	Homo sapiens	Q7Z3Y7	Y2H Prey Pooling	32296183
Intra	KRT81	Q14533	KRT26	Homo sapiens	Q7Z3Y9	Y2H Prey Pooling	32296183
Intra	KRT81	Q14533	KRT26	Homo sapiens	Q7Z3Y9	Y2H Array	32296183
Intra	KRT81	Q14533	KRT26	Homo sapiens	Q7Z3Y9	Validated Y2H	32296183
Intra	KRT81	Q14533	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	KRT81	Q14533	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	KRT81	Q14533	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	KRT81	Q14533	KRT18	Homo sapiens	P05783	Y2H Array	32296183
Intra	KRT81	Q14533	KRT18	Homo sapiens	P05783	Y2H Prey Pooling	32296183
Intra	KRT81	Q14533	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	KRT81	Q14533	KRT27	Homo sapiens	Q7Z3Y8	Validated Y2H	32296183
Intra	KRT81	Q14533	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	KRT81	Q14533	KRT16	Homo sapiens	P08779	Y2H Array	32296183
Intra	KRT81	Q14533	KRT16	Homo sapiens	P08779	Y2H Prey Pooling	32296183
Intra	KRT81	Q14533	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	KRT81	Q14533	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Cross	KRT81	Q14533	Hoxa1	Mus musculus	P09022	BiFC	23088713
Cross	KRT81	Q14533	Hoxa1	Mus musculus	P09022	Pull Down	23088713
Intra	KRT81	Q14533	OIP5	Homo sapiens	O43482	Y2H Array	32296183
Intra	KRT81	Q14533	OIP5	Homo sapiens	O43482	Y2H Prey Pooling	32296183
Intra	KRT81	Q14533	KRT14	Homo sapiens	P02533	Y2H Array	32296183
Intra	KRT81	Q14533	KRT14	Homo sapiens	P02533	Y2H Prey Pooling	32296183
Intra	KRT81	Q14533	KRT15	Homo sapiens	P19012	Y2H Array	32296183
Intra	KRT81	Q14533	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	32296183
Intra	KRT81	Q14533	KXD1	Homo sapiens	Q9BQD3	Pull Down	16189514
Intra	KRT81	Q14533	KXD1	Homo sapiens	Q9BQD3	Y2H Pooling	16189514
Intra	KRT81	Q14533	OTX1	Homo sapiens	P32242	Y2H Array	25416956
Intra	KRT81	Q14533	OTX1	Homo sapiens	P32242	Y2H Array	32296183
Intra	KRT81	Q14533	OTX1	Homo sapiens	P32242	Y2H Prey Pooling	25416956
Intra	KRT81	Q14533	HOXA1	Homo sapiens	P49639	Y2H Array	32296183
Intra	KRT81	Q14533	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	KRT81	Q14533	KRT19	Homo sapiens	P08727	Y2H Prey Pooling	32296183
Intra	KRT81	Q14533	KRT19	Homo sapiens	P08727	Y2H Array	32296183
Intra	KRT81	Q14533	LCA5L	Homo sapiens	O95447	Y2H Prey Pooling	32296183
Intra	KRT81	Q14533	LCA5L	Homo sapiens	O95447	Y2H Array	32296183
Intra	KRT81	Q14533	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	KRT81	Q14533	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956
Intra	KRT81	Q14533	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	KRT81	Q14533	KRT31	Homo sapiens	Q15323	Y2H Array	25416956
Intra	KRT81	Q14533	KRT31	Homo sapiens	Q15323	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Monilethrix

Beaded Hair	MNLIX
Nodose Hair	Moniliform Hair Syndrome

Hair Disease

Hair Diseases	Hair Anomaly
Hair Disorder	Hair Problems

Pilomatrixoma

Pilomatricoma	PTR
Epithelioma Calcificans Of Malherbe	Benign Pilomatricoma
Calcifying Epithelioma Of Malherbe	Pilomatricoma, Somatic
Benign Pilomatrixoma	Malherbe Calcifying Epithelioma

Hypotrichosis 6

HYPT6	Lah1
Hypotrichosis, Localized, Autosomal Recessive	Monilethrix-Like Hypotrichosis
Hypotrichosis, Localized, Autosomal Recessive 1	Lah
Htl	Autosomal Recessive Localized Hypotrichosis
Hypotrichosis Localized Autosomal Recessive	Hypotrichosis Localized Autosomal Recessive 1
Hypotrichosis, Type 6

Epidermolytic Hyperkeratosis

Bullous Congenital Ichthyosiform Erythroderma	Bullous Ichthyosiform Erythroderma
EHK	Bullous Erythroderma Ichthyosiformis Congenita Of Brocq
Bcie	Bie
Epidermolytic Ichthyosis	Ichthyosis Bullosa Of Siemens
Superficial Epidermolytic Ichthyosis	Hyperkeratosis, Epidermolytic
Congenital Bullous Ichthyosiform Erythroderma	Bullous Type Ichthyosis
Epidermolytic Palmoplantar Hyperkeratosis	Bullous Ichthyosiform Erythroderma Congenita
Bullous Erythroderma Ichthyosiforme	Sei
Epidermolytic Hyperkeratosis Late-Onset	Epidermolytic Hyperkeratosis, Late-Onset

Nail Disorder, Nonsyndromic Congenital, 4

Anonychia Congenita	Anonychia
Hyponychia Congenita	NDNC4
Anonychia/Hyponychia Congenita	Nonsyndromic Congenital Nail Disorder 4
Isolated Congenital Anonychia	Anonychia Congenita Totalis
Anonychia Totalis	Autosomal Recessive Nonsyndromic Congenital Nail Disorder-4
Congenital Anonychia	Nonsyndromic Congenital Nail Disorder, 4
Absent Nails	Aplastic Nails
Congenital Absence Of Nails	Isolated Anonychia
Nail Disorder, Non-Syndromic Congenital, 4	Nail Disorder, Nonsyndromic, Congenital, Type 4

Ectodermal Dysplasia 4, Hair/Nail Type

Pure Hair And Nail Ectodermal Dysplasia	ECTD4
Ectodermal Dysplasia, Pure Hair-Nail Type	Ectodermal Dysplasia, 'Pure' Hair/Nail Type
Hned	Hair-Nail Ectodermal Dysplasia
Phned	Ectodermal Dysplasia Pure Hair-Nail Type
Ectodermal Dysplasia, 'Pure' Hair-Nail Type	Dysplasia, Ectodermal, Type 4, Hair/Nail

Nonsyndromic Congenital Nail Disorder

Nail Disorder, Nonsyndromic Congenital

Familial Woolly Hair Syndrome

Wooly Hair	Familial Wooly Hair Syndrome
Hereditary Woolly Hair Syndrome	Hereditary Wooly Hair Syndrome
Woolly Hair	Syndrome With Woolly Hair
Wooly Hair Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07469	KRT81 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KRT81	MGD	MGI:1928858
Rattus norvegicus	KRT81	RGD	RGD:1303316

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