LOXL2 - lysyl oxidase like 2 Gene

Homo sapiens

Also known as LOR; LOR2; WS9-14

Gene ID: 4017 | Gene type: protein coding

About LOXL2

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:23,296,897-23,404,120 (from NCBI)

This gene has 15 transcripts (splice variants), 289 orthologues and 15 paralogues. Broad expression in placenta (RPKM 21.2), fat (RPKM 16.1) and 20 other tissues.

Summary

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]

LOXL2 Products(1)

mRNA	Protein	Name
NM_002318.3	NP_002309.1	lysyl oxidase homolog 2 precursor

LOXL2 Protein Structure

SRCR

Lysyl_oxidase

0
200
400
600
774 a.a.

Protein Preferred Names

Protein Names

lysyl oxidase homolog 2

lysyl oxidase related 2

LOXL2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LOXL2	Q9Y4K0	FN1	Homo sapiens	P02751	SPR	31759052
Intra	LOXL2	Q9Y4K0	FN1	Homo sapiens	P02751	PLA	31759052
Intra	LOXL2	Q9Y4K0	VIM	Homo sapiens	P08670	Anti Tag CoIP	31911079
Intra	LOXL2	Q9Y4K0	VIM	Homo sapiens	P08670	Anti Bait CoIP	31911079
Intra	LOXL2	Q9Y4K0	VIM	Homo sapiens	P08670	PLA	31911079
Intra	LOXL2	Q9Y4K0	MARCKSL1	Homo sapiens	P49006	Anti Tag CoIP	24863880
Intra	LOXL2	Q9Y4K0	MARCKSL1	Homo sapiens	P49006	Y2H	24863880
Intra	LOXL2	Q9Y4K0	MARCKSL1	Homo sapiens	P49006	Anti Bait CoIP	24863880
Intra	LOXL2	Q9Y4K0	ELN	Homo sapiens	P15502-2	SPR	30676771
Intra	LOXL2	Q9Y4K0	ELN	Homo sapiens	P15502-2	Deamination	30676771

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LOXL2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74770	LOXL2 Protein, Human (HEK293, His)	Q9Y4K0 (M26-Q774)	≥95%
HY-P74771	LOXL2 Protein, Human (CHO, His)	Q9Y4K0 (M26-Q774)	≥95%

Related Diseases

Diseases

Alias

Hyperostosis Cranialis Interna

HCIN	Hyperostosis Cranalis Interna

Cutis Laxa

Generalized Elastolysis	Loose Skin
Dermatolysis	Dermatomegaly
Cutis Laxa Syndrome

Distal Muscular Dystrophy With Anterior Tibial Onset

Dmat

Pelvic Inflammatory Disease

Pid

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Long Qt Syndrome

Romano-Ward Syndrome	Long Q-T Syndrome
Lqt	Qt Syndrome, Long
Congenital Long Qt Syndrome	Familial Long Qt Syndrome

Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis	PSC
Sclerosing Cholangitis	Cholangitis, Sclerosing
Cholangitis Primary Sclerosing	Psc - [Primary Sclerosing Cholangitis]

Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis	Ipf
Fibrocystic Pulmonary Dysplasia	Pulmonary Fibrosis, Idiopathic
Pulmonary Fibrosis, Idiopathic, Susceptibility To	Cryptogenic Fibrosing Alveolitis
ILD2	Idiopathic Pulmonary Fibrosis, Familial
Fibrosing Alveolitis, Cryptogenic	Uip
Fibrosing Alveolitis	Interstitial Pneumonitis, Usual
Familial Idiopathic Pulmonary Fibrosis	Idiopathic Fibrosing Alveolitis, Chronic Form
Usual Interstitial Pneumonia	Fibrosing Alveolitis Cryptogenic
Hamman-Rich Disease	Idiopathic Pulmonary Fibrosis Familial
Interstitial Pneumonitis Usual	Fibrosis Idiopathic Pulmonary
Fibrosis, Pulmonary, Idiopathic	Hamman-Rich Syndrome
Chronic Idiopathic Pulmonary Fibrosis	Acute Interstitial Pneumonia
Interstitial Pulmonary Fibrosis	Ipf - [Idiopathic Pulmonary Fibrosis]
Idiopathic Lung Fibrosis	Fibrosing Lung Disease
Pulmonary Fibrosis Nos	Fibrosing Pneumonitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-107422	Lenumlostat		99.52%	Phase 2
HY-107422A	Lenumlostat hydrochloride		/	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99047	Simtuzumab	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101771A	(2-Chloropyridin-4-yl)methanamine hydrochloride		99.70%	Unkown
HY-138625	LOX-IN-3	Inhibitor	99.97%	Unkown
HY-114286A	PXS-5153A monohydrochloride	Inhibitor	99.67%	Unkown
HY-138625A	LOX-IN-3 dihydrochloride	Inhibitor	99.97%	Unkown
HY-151499A	PXS-6302 hydrochloride	Inhibitor	99.83%	Unkown
HY-N0554	Escin IA	Inhibitor	99.59%	Unkown
HY-130242	PXS-5120A		98.02%	Unkown
HY-114286	PXS-5153A	Inhibitor	/	Unkown
HY-151498	PXS-4787	Inhibitor	/	Unkown
HY-151498A	PXS-4787 hydrochloride	Inhibitor	99.71%	Unkown
HY-151499	PXS-6302	Inhibitor	/	Unkown
HY-138625B	LOX-IN-3 dihydrochloride monohydrate	Inhibitor	/	Unkown
HY-RS07742	LOXL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LOXL2	MGD	MGI:2137913
Bos taurus	LOXL2	VGNC	VGNC:30953
Rattus norvegicus	LOXL2	RGD	RGD:1308435
Canis familiaris	LOXL2	VGNC	VGNC:42739
Felis catus	LOXL2	VGNC	VGNC:68080
Others	LOXL2	NCBI

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