CNOT3 - CCR4-NOT transcription complex subunit 3 Gene

Homo sapiens

Also known as NOT3; LENG2; NOT3H; IDDSADF

Gene ID: 4849 | Gene type: protein coding

About CNOT3

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,137,762-54,155,681 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 270 orthologues, 1 paralogue and is associated with 74 phenotypes. Ubiquitous expression in testis (RPKM 13.9), spleen (RPKM 9.7) and 25 other tissues.

Summary

Involved in regulation of stem cell population maintenance. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]

CNOT3 Products(1)

mRNA	Protein	Name
NM_014516.4	NP_055331.1	CCR4-NOT transcription complex subunit 3

CNOT3 Protein Structure

Not3

NOT2_3_5

0
200
400
600
753 a.a.

Protein Preferred Names

Protein Names

CCR4-NOT transcription complex subunit 3

CCR4-associated factor 3

CNOT3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CNOT3	O75175	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	33961781
Intra	CNOT3	O75175	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	17452450
Intra	CNOT3	O75175	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
Intra	CNOT3	O75175	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
Intra	CNOT3	O75175	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
Intra	CNOT3	O75175	CNOT1	Homo sapiens	A5YKK6	Anti Bait CoIP	16778766
Intra	CNOT3	O75175	CNOT1	Homo sapiens	A5YKK6	Anti Tag CoIP	33961781
Intra	CNOT3	O75175	CNOT6	Homo sapiens	Q9ULM6	Anti Tag CoIP	33961781
Intra	CNOT3	O75175	DLST	Homo sapiens	P36957	Validated Y2H	32814053
Intra	CNOT3	O75175	DLST	Homo sapiens	P36957	Y2H Pooling	32814053
Intra	CNOT3	O75175	DLST	Homo sapiens	P36957	Y2H Array	32814053
Intra	CNOT3	O75175	VCP	Homo sapiens	P55072	Y2H Array	32814053
Intra	CNOT3	O75175	VCP	Homo sapiens	P55072	Y2H Pooling	32814053
Intra	CNOT3	O75175	VCP	Homo sapiens	P55072	Validated Y2H	32814053
Cross	CNOT3	O75175	Cand2	Mus musculus	Q6ZQ73	Y2H	12207886
Intra	CNOT3	O75175	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	CNOT3	O75175	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
Intra	CNOT3	O75175	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053
Intra	CNOT3	O75175	TOB1	Homo sapiens	P50616	Anti Tag CoIP	18377426
Intra	CNOT3	O75175	TOB1	Homo sapiens	P50616	TAP	18377426
Intra	CNOT3	O75175	CNOT8	Homo sapiens	Q9UFF9	Anti Tag CoIP	33961781
Intra	CNOT3	O75175	CNOT8	Homo sapiens	Q9UFF9	Anti Bait CoIP	10637334
Intra	CNOT3	O75175	CNOT8	Homo sapiens	Q9UFF9	Y2H	10637334
Intra	CNOT3	O75175	CNOT2	Homo sapiens	Q9NZN8	Anti Bait CoIP	21984185
Intra	CNOT3	O75175	CNOT2	Homo sapiens	Q9NZN8	Validated Y2H	32296183
Intra	CNOT3	O75175	CNOT2	Homo sapiens	Q9NZN8	Anti Bait CoIP	16778766
Intra	CNOT3	O75175	CNOT2	Homo sapiens	Q9NZN8	Anti Tag CoIP	33961781
Intra	CNOT3	O75175	CNOT2	Homo sapiens	Q9NZN8	Y2H Array	32296183
Intra	CNOT3	O75175	CNOT2	Homo sapiens	Q9NZN8	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder With Speech Delay, Autism, And Dysmorphic Facies

IDDSADF

Intellectual Developmental Disorder With Speech Delay, Autism And Dysmorphic Facies

Precursor T-Cell Acute Lymphoblastic Leukemia

T-All	Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma
Precursor T-Cell Acute Lymphocytic Leukemia	Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Adult T-Cell Lymphoma/Leukemia

Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02903	CNOT3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CNOT3	VGNC	VGNC:27518
Rattus norvegicus	CNOT3	RGD	RGD:1304771
Mus musculus	CNOT3	MGD	MGI:2385261
Macaca mulatta	CNOT3	VGNC	VGNC:71388
Canis familiaris	CNOT3	VGNC	VGNC:39414

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