ROR1 - receptor tyrosine kinase like orphan receptor 1 Gene

Homo sapiens

Also known as NTRKR1; dJ537F10.1

Gene ID: 4919 | Gene type: protein coding

About ROR1

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:63,774,017-64,181,498 (from NCBI)

This gene has 3 transcripts (splice variants), 209 orthologues, 53 paralogues and is associated with 2 phenotypes. Ubiquitous expression in lung (RPKM 2.7), endometrium (RPKM 2.2) and 23 other tissues.

Summary

This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]

ROR1 Products(2)

mRNA	Protein	Name
NM_001083592.2	NP_001077061.1	inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 2 precursor
NM_005012.4	NP_005003.2	inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 1 precursor

ROR1 Protein Structure

I-set

Kringle

Pkinase_Tyr

0
200
400
600
800
937 a.a.

Protein Preferred Names

Protein Names

inactive tyrosine-protein kinase transmembrane receptor ROR1

neurotrophic tyrosine kinase, receptor-related 1

Recombinant ROR1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70732	ROR1 Protein, Human (HEK293, His)	Q01973-1 (Q30-E403)	≥95%
HY-P72410	ROR1 Protein, Human (Biotinylated, HEK293, His-Avi)	Q01973-1 (Q30-E403)	≥95%
HY-P73390	ROR1 Protein, Human (sf9, His)	Q01973 (M453-N783)	≥95%
HY-P78510	ROR1 Protein, Human (HEK293, His-Avi)	Q01973-1 (Q30-E403)	≥95%

Related Diseases

Diseases

Alias

Deafness, Autosomal Recessive 108

DFNB108

Deafness, Autosomal Recessive, 108

Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb

Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb	Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb	Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb	Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Robinow Syndrome

Acral Dysostosis With Facial And Genital Abnormalities	Fetal Face Syndrome
Robinow Dwarfism	Mesomelic Dwarfism-Small Genitalia Syndrome
Robinow-Silverman-Smith Syndrome	Costovertebral Segmentation Defect With Mesomelia
Covesdem Syndrome	Robinow'S Syndrome
Robinow-Silverman Syndrome

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99201	Zilovertamab	Inhibitor	98.20%	Phase 3
HY-P99956	Zilovertamab vedotin	Inducer	98.15%	Phase 3

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139534	ARI-1		99.76%	Unkown
HY-139534A	(S)-ARI-1		99.80%	Unkown
HY-117947	(R)-OR-S1		/	Unkown
HY-161096	Antitumor agent-127		/	Unkown
HY-162640	ROR1-IN-1	Inhibitor	/	Unkown
HY-RS12124	ROR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-160790	β-Glu-PNP		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ROR1	RGD	RGD:1559469
Bos taurus	ROR1	VGNC	VGNC:55673
Canis familiaris	ROR1	VGNC	VGNC:45693
Mus musculus	ROR1	MGD	MGI:1347520
Macaca mulatta	ROR1	VGNC	VGNC:76715
Felis catus	ROR1	VGNC	VGNC:64719
Others	ROR1	NCBI

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