2. Gene
  3. Si - sucrase-isomaltase Gene

Si - sucrase-isomaltase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as SUCIMAL

Gene ID: 497756 | Gene type: protein coding

About Si

Summary

Enables beta-fructofuranosidase activity and oligo-1,6-glucosidase activity. Involved in several processes, including response to fructose; response to sucrose; and response to vitamin A. Located in brush border and membrane raft. Biomarker of colitis. Human ortholog(s) of this gene implicated in congenital sucrase-isomaltase deficiency. Orthologous to human SI (sucrase-isomaltase). [provided by Alliance of Genome Resources, Apr 2022]

Si Products(1)

mRNA Protein Name
NM_001389226.1 NP_001376155.1 sucrase-isomaltase, intestinal
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables beta-fructofuranosidase activity IDA
IDA: Inferred from direct assay
6802834 RGD
enables oligo-1,6-glucosidase activity IDA
IDA: Inferred from direct assay
6802834 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15138292 RGD
Biological Process GO Annotation Evidence Reference Source
involved in response to fructose IEP
IEP: Inferred from expression pattern
15539244 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
9618286 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
9585003 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
7873573 RGD
involved in response to starvation IEP
IEP: Inferred from expression pattern
10864000 RGD
involved in response to sucrose IEP
IEP: Inferred from expression pattern
8890076 RGD
involved in response to vitamin A IEP
IEP: Inferred from expression pattern
15309444 RGD
Cellular Component GO Annotation Evidence Reference Source
located in brush border IDA
IDA: Inferred from direct assay
15138292 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sucrase-isomaltase, intestinal

sucrase-isomaltase (alpha-glucosidase)

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-109525 Sacrosidase / Unkown
Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99676 Izalontamab Inhibitor 99.89% Phase 3
Pre-clinical Phase
Bioactive Molecules (50)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-126247 BI-2852 Inhibitor 99.57% Unkown
HY-129602 SD-36 99.73% Unkown
HY-134818 ML-SI1 Inhibitor 99.85% Unkown
HY-139426 ML-SI3 Inhibitor 99.91% Unkown
HY-129603 SI-109 Inhibitor 99.91% Unkown
HY-134819A (1R,2R)-ML-SI3 Inhibitor 99.45% Unkown
HY-D0175 3-Aminopropyltriethoxysilane 99.91% Unkown
HY-139426A (rel)-ML-SI3 99.81% Unkown
HY-101447A SI-2 hydrochloride Inhibitor 99.79% Unkown
HY-139218 (S,R,S)-AHPC-Me-C6-NH2 99.14% Unkown
HY-130812 Gemcitabine-O-Si(di-iso)-O-Mc 98.82% Unkown
HY-117357 SI-113 Inhibitor 98.02% Unkown
HY-126247B (R)-BI-2852 Control 97.32% Unkown
HY-121537 CAY10404 99.69% Unkown
HY-134819 (1S,2S)-ML-SI3 Inhibitor 99.82% Unkown
HY-130818 N-(5-Hydroxypentyl)maleimide 99.89% Unkown
HY-137498 EBOV/MARV-IN-1 Inhibitor 99.14% Unkown
HY-163469 SRC-3-IN-2 Inhibitor 96.32% Unkown
HY-150926 G12Si-1 Inhibitor / Unkown
HY-150927 G12Si-2 Inhibitor / Unkown
HY-101447 SI-2 / Unkown
HY-115929 DENV-IN-4 Inhibitor / Unkown
HY-115989 HCV-IN-38 Inhibitor / Unkown
HY-119396 DY3002 / Unkown
HY-121582 (E)-SI-2 / Unkown
HY-131721 14,15-EET-SI / Unkown
HY-139845 Antiviral agent 9 Inhibitor / Unkown
HY-144749 AKR1C3-IN-5 Inhibitor / Unkown
HY-145432 PI3K-IN-28 Inhibitor / Unkown
HY-146815 CP19 / Unkown
HY-150554 Antitubercular agent-29 Inhibitor / Unkown
HY-151174 PDE4-IN-12 Inhibitor / Unkown
HY-151612 Anti-infective agent 6 Inhibitor / Unkown
HY-162833 Antileishmanial agent-30 Inhibitor / Unkown
HY-163468 SRC-3-IN-1 Inhibitor / Unkown
HY-168301 CL-13 Inhibitor / Unkown
HY-169968 E3 ligase Ligand 41 / Unkown
HY-170958 Scr-IN-1 / Unkown
HY-B0389S20 D-Glucose-13C,d-1 / Unkown
HY-B0389S22 D-Glucose-13C2,d2 / Unkown
HY-N10564 8α,9α-Epoxycoleon-U-quinone Modulator / Unkown
HY-RS12889 SI Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W026467 MMV665916 Inhibitor / Unkown
HY-121914 (2-Chlorophenyl)diphenylmethanol Inhibitor / Unkown
HY-159915 Se2h Inhibitor / Unkown
HY-164527 Si306 Inhibitor / Unkown
HY-165603 Si5-N14 Inhibitor / Unkown
HY-169920 HIV-1 inhibitor-79 Inhibitor / Unkown
HY-170922 SARS-CoV-2-IN-110 Inhibitor / Unkown
HY-170940 Dyrk1A-IN-12 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Si NCBI NCBI:6476
Canis familiaris Si NCBI NCBI:488141
Macaca fascicularis Si NCBI NCBI:102128108
Canis lupus familiaris Si NCBI
Mus musculus Si NCBI
Susscrofa domestica Si NCBI
Leporidae Si NCBI
Macaca mulatta Si NCBI NCBI:700840