1. Gene
  2. USP2 - ubiquitin specific peptidase 2 Gene

USP2 - ubiquitin specific peptidase 2 Gene

Homo sapiens

Also known as USP9; UBP41

Gene ID: 9099 | Gene type: protein coding

About USP2

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:119,355,215-119,381,690 (from NCBI)

This gene has 7 transcripts (splice variants), 178 orthologues and 71 paralogues. Biased expression in testis (RPKM 31.4), kidney (RPKM 15.4) and 10 other tissues.

Summary

This gene encodes a member of the family of de-ubiquitinating Enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a Ubiquitin-Specific Protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

USP2 Products(3)

mRNA Protein Name
NM_001243759.2 NP_001230688.1 ubiquitin carboxyl-terminal hydrolase 2 isoform c
NM_004205.5 NP_004196.4 ubiquitin carboxyl-terminal hydrolase 2 isoform a
NM_171997.3 NP_741994.1 ubiquitin carboxyl-terminal hydrolase 2 isoform b

USP2 Protein Structure

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (267 - 596)

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  • 605 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 2

41 kDa ubiquitin-specific protease

Recombinant USP2 Proteins

Cat. No. Product Name Accession Purity
HY-P79457 USP2 Catalytic Domain Protein, Human (His) O75604-1 (N259-M605) ≥95%

Related Diseases

Diseases Alias
Machado-Joseph Disease

SCA3

MJD

Spinocerebellar Ataxia 3

Azorean Disease

Spinocerebellar Ataxia Type 3

Spinocerebellar Atrophy

Azorean Neurologic Disease

Spinopontine Atrophy

Nigrospinodentatal Degeneration

Spinocerebellar Atrophy Iii

Spinocerebellar Atrophy Type 3

Azorean Ataxia

Azorean Disease Of The Nervous System

Machado Disease

Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia

Disease, Machado-Joseph

Ataxia, Spinocerebellar

Fasciitis
Liddle Syndrome 1

Liddle Syndrome

Pseudoaldosteronism

Liddle'S Syndrome

LIDLS1

Lidls

Pseudohyperaldosteronism

Pseudoprimary Hyperaldosteronism

Pseudohyperaldosteronism Type 1

Liddles Syndrome

Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism

Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia

Adca

Pierre Marie Cerebellar Ataxia

Ataxia, Spinocerebellar

Sca

Autosomal Dominant Spinocerebellar Ataxia

Spinocerebellar Ataxias

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus USP2 RGD RGD:621073
Macaca mulatta USP2 VGNC VGNC:101425
Felis catus USP2 VGNC VGNC:81096
Mus musculus USP2 MGD MGI:1858178
Bos taurus USP2 VGNC VGNC:54894
Others USP2 NCBI