USP2 - ubiquitin specific peptidase 2 Gene

Homo sapiens

Also known as USP9; UBP41

Gene ID: 9099 | Gene type: protein coding

About USP2

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:119,355,215-119,381,690 (from NCBI)

This gene has 7 transcripts (splice variants), 178 orthologues and 71 paralogues. Biased expression in testis (RPKM 31.4), kidney (RPKM 15.4) and 10 other tissues.

Summary

This gene encodes a member of the family of de-ubiquitinating Enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a Ubiquitin-Specific Protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

USP2 Products(3)

mRNA	Protein	Name
NM_001243759.2	NP_001230688.1	ubiquitin carboxyl-terminal hydrolase 2 isoform c
NM_004205.5	NP_004196.4	ubiquitin carboxyl-terminal hydrolase 2 isoform a
NM_171997.3	NP_741994.1	ubiquitin carboxyl-terminal hydrolase 2 isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables cyclin binding	IPI IPI: Inferred from physical interaction	19917254	GOA
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	17290220	GOA
enables cysteine-type deubiquitinase activity	IMP IMP: Inferred from mutant phenotype	19917254	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	17290220	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17290220	GOA
involved in positive regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	17290220	GOA
involved in protein deubiquitination	IDA IDA: Inferred from direct assay	19838211	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	17290220	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	19838211	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP2 Protein Structure

UCH

0
100
200
300
400
500
605 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase 2

41 kDa ubiquitin-specific protease

USP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	USP2	O75604	CCDC136	Homo sapiens	Q96JN2-2	Y2H Prey Pooling	25416956
Intra	USP2	O75604	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	USP2	O75604	KRT40	Homo sapiens	Q6A162	Validated Y2H	32296183
Intra	USP2	O75604	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	USP2	O75604	KRT40	Homo sapiens	Q6A162	Y2H Array	32296183
Intra	USP2	O75604	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	32296183
Intra	USP2	O75604	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	32296183
Intra	USP2	O75604	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
Intra	USP2	O75604	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	32296183
Intra	USP2	O75604	NEFL	Homo sapiens	I6L9F6	Y2H Array	25416956
Intra	USP2	O75604	CADPS	Homo sapiens	A2RRN7	Y2H Array	32296183
Intra	USP2	O75604	CADPS	Homo sapiens	A2RRN7	Y2H Prey Pooling	32296183
Intra	USP2	O75604	KRT34	Homo sapiens	O76011	Validated Y2H	32296183
Intra	USP2	O75604	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	USP2	O75604	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	USP2	O75604	KRT33B	Homo sapiens	Q14525	Y2H Prey Pooling	32296183
Intra	USP2	O75604	KRT33B	Homo sapiens	Q14525	Validated Y2H	32296183
Intra	USP2	O75604	KRT33B	Homo sapiens	Q14525	Y2H Array	32296183
Intra	USP2	O75604	KRT35	Homo sapiens	Q92764	Y2H Array	32296183
Intra	USP2	O75604	KRT35	Homo sapiens	Q92764	Validated Y2H	32296183
Intra	USP2	O75604	KRT35	Homo sapiens	Q92764	Y2H Prey Pooling	32296183
Intra	USP2	O75604	HOOK2	Homo sapiens	Q96ED9-2	Validated Y2H	32296183
Intra	USP2	O75604	HOOK2	Homo sapiens	Q96ED9-2	Y2H Array	32296183
Intra	USP2	O75604	HOOK2	Homo sapiens	Q96ED9-2	Y2H Prey Pooling	32296183
Intra	USP2	O75604	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	USP2	O75604	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	USP2	O75604	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	USP2	O75604	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	USP2	O75604	ABI2	Homo sapiens	Q9NYB9-2	Y2H Array	32296183
Intra	USP2	O75604	ABI2	Homo sapiens	Q9NYB9-2	Y2H Prey Pooling	32296183
Intra	USP2	O75604	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Prey Pooling	32296183
Intra	USP2	O75604	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Array	32296183
Intra	USP2	O75604	GOLGA6A	Homo sapiens	Q9NYA3	Validated Y2H	32296183
Intra	USP2	O75604	GPRASP3	Homo sapiens	Q6PI77	Validated Y2H	32296183
Intra	USP2	O75604	GPRASP3	Homo sapiens	Q6PI77	Y2H Prey Pooling	32296183
Intra	USP2	O75604	GPRASP3	Homo sapiens	Q6PI77	Y2H Array	32296183
Intra	USP2	O75604	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	32296183
Intra	USP2	O75604	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	USP2	O75604	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	USP2	O75604	CEP63	Homo sapiens	Q96MT8-3	Validated Y2H	32296183
Intra	USP2	O75604	CEP63	Homo sapiens	Q96MT8-3	Y2H Prey Pooling	32296183
Intra	USP2	O75604	CEP63	Homo sapiens	Q96MT8-3	Y2H Array	32296183
Intra	USP2	O75604	CARD9	Homo sapiens	Q9H257-2	Y2H Array	32296183
Intra	USP2	O75604	CARD9	Homo sapiens	Q9H257-2	Y2H Prey Pooling	32296183
Intra	USP2	O75604	CARD9	Homo sapiens	Q9H257-2	Validated Y2H	32296183
Intra	USP2	O75604	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	USP2	O75604	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	USP2	O75604	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	USP2	O75604	STAT5B	Homo sapiens	P51692	Y2H Array	32296183
Intra	USP2	O75604	STAT5B	Homo sapiens	P51692	Y2H Prey Pooling	32296183
Intra	USP2	O75604	STAT5B	Homo sapiens	P51692	Validated Y2H	32296183
Intra	USP2	O75604	ATN1	Homo sapiens	Q86V38	Y2H Prey Pooling	32296183
Intra	USP2	O75604	ATN1	Homo sapiens	Q86V38	Y2H Array	32296183
Intra	USP2	O75604	ATN1	Homo sapiens	Q86V38	Validated Y2H	32296183
Intra	USP2	O75604	RUNDC3A	Homo sapiens	Q59EK9-3	Y2H Prey Pooling	32296183
Intra	USP2	O75604	RUNDC3A	Homo sapiens	Q59EK9-3	Validated Y2H	32296183
Intra	USP2	O75604	RUNDC3A	Homo sapiens	Q59EK9-3	Y2H Array	32296183
Intra	USP2	O75604	SPAG8	Homo sapiens	Q99932-2	Y2H Prey Pooling	32296183
Intra	USP2	O75604	SPAG8	Homo sapiens	Q99932-2	Validated Y2H	32296183
Intra	USP2	O75604	SPAG8	Homo sapiens	Q99932-2	Y2H Array	32296183
Intra	USP2	O75604	ZIM2	Homo sapiens	Q9NZV7	Validated Y2H	32296183
Intra	USP2	O75604	ZIM2	Homo sapiens	Q9NZV7	Y2H Prey Pooling	32296183
Intra	USP2	O75604	ZIM2	Homo sapiens	Q9NZV7	Y2H Array	32296183
Intra	USP2	O75604	BICD2	Homo sapiens	Q8TD16-2	Validated Y2H	32296183
Intra	USP2	O75604	BICD2	Homo sapiens	Q8TD16-2	Y2H Array	32296183
Intra	USP2	O75604	BICD2	Homo sapiens	Q8TD16-2	Y2H Prey Pooling	32296183
Intra	USP2	O75604	USP54	Homo sapiens	Q70EL1-9	Y2H Array	32296183
Intra	USP2	O75604	USP54	Homo sapiens	Q70EL1-9	Y2H Prey Pooling	32296183
Intra	USP2	O75604	USP54	Homo sapiens	Q70EL1-9	Validated Y2H	32296183
Intra	USP2	O75604	CRACR2B	Homo sapiens	Q8N4Y2-3	Y2H Prey Pooling	32296183
Intra	USP2	O75604	CRACR2B	Homo sapiens	Q8N4Y2-3	Validated Y2H	32296183
Intra	USP2	O75604	CRACR2B	Homo sapiens	Q8N4Y2-3	Y2H Array	32296183
Intra	USP2	O75604	DISC1	Homo sapiens	Q9NRI5-2	Y2H Prey Pooling	32296183
Intra	USP2	O75604	DISC1	Homo sapiens	Q9NRI5-2	Validated Y2H	32296183
Intra	USP2	O75604	DISC1	Homo sapiens	Q9NRI5-2	Y2H Array	32296183
Intra	USP2	O75604	GRB7	Homo sapiens	Q14451-3	Validated Y2H	32296183
Intra	USP2	O75604	GRB7	Homo sapiens	Q14451-3	Y2H Prey Pooling	32296183
Intra	USP2	O75604	GRB7	Homo sapiens	Q14451-3	Y2H Array	32296183
Intra	USP2	O75604	KAZN	Homo sapiens	Q674X7-2	Validated Y2H	32296183
Intra	USP2	O75604	KAZN	Homo sapiens	Q674X7-2	Y2H Array	32296183
Intra	USP2	O75604	KAZN	Homo sapiens	Q674X7-2	Y2H Prey Pooling	32296183
Intra	USP2	O75604	LHX3	Homo sapiens	Q9UBR4-2	Y2H Array	32296183
Intra	USP2	O75604	LHX3	Homo sapiens	Q9UBR4-2	Y2H Prey Pooling	32296183
Intra	USP2	O75604	LHX3	Homo sapiens	Q9UBR4-2	Validated Y2H	32296183
Intra	USP2	O75604	SPDYE4	Homo sapiens	A6NLX3	Y2H Array	32296183
Intra	USP2	O75604	SPDYE4	Homo sapiens	A6NLX3	Y2H Prey Pooling	32296183
Intra	USP2	O75604	VPS28	Homo sapiens	Q9UK41-2	Validated Y2H	32296183
Intra	USP2	O75604	VPS28	Homo sapiens	Q9UK41-2	Y2H Array	32296183
Intra	USP2	O75604	VPS28	Homo sapiens	Q9UK41-2	Y2H Prey Pooling	32296183
Intra	USP2	O75604	DEPDC5	Homo sapiens	O75140-2	Y2H Prey Pooling	32296183
Intra	USP2	O75604	DEPDC5	Homo sapiens	O75140-2	Y2H Array	32296183
Intra	USP2	O75604	MORN5	Homo sapiens	Q5VZ52	Validated Y2H	32296183
Intra	USP2	O75604	MORN5	Homo sapiens	Q5VZ52	Y2H Array	32296183
Intra	USP2	O75604	MORN5	Homo sapiens	Q5VZ52	Y2H Prey Pooling	32296183
Intra	USP2	O75604	PIBF1	Homo sapiens	Q4G0R1	Validated Y2H	32296183
Intra	USP2	O75604	PIBF1	Homo sapiens	Q4G0R1	Y2H Array	32296183
Intra	USP2	O75604	PIBF1	Homo sapiens	Q4G0R1	Y2H Prey Pooling	32296183
Intra	USP2	O75604	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Prey Pooling	32296183
Intra	USP2	O75604	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	USP2	O75604	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Array	32296183
Intra	USP2	O75604	PRR5L	Homo sapiens	Q6MZQ0	Y2H Prey Pooling	32296183
Intra	USP2	O75604	PRR5L	Homo sapiens	Q6MZQ0	Validated Y2H	32296183
Intra	USP2	O75604	PRR5L	Homo sapiens	Q6MZQ0	Y2H Array	32296183
Intra	USP2	O75604	JRK	Homo sapiens	O75564-2	Y2H Prey Pooling	32296183
Intra	USP2	O75604	JRK	Homo sapiens	O75564-2	Y2H Array	32296183
Intra	USP2	O75604	ASPG	Homo sapiens	Q86U10	Y2H Prey Pooling	32296183
Intra	USP2	O75604	ASPG	Homo sapiens	Q86U10	Validated Y2H	32296183
Intra	USP2	O75604	ASPG	Homo sapiens	Q86U10	Y2H Array	32296183
Intra	USP2	O75604	SH2B2	Homo sapiens	O14492-2	Y2H Prey Pooling	32296183
Intra	USP2	O75604	SH2B2	Homo sapiens	O14492-2	Y2H Array	32296183
Intra	USP2	O75604	KIFC3	Homo sapiens	Q9BVG8	Validated Y2H	25416956
Intra	USP2	O75604	KIFC3	Homo sapiens	Q9BVG8	Y2H Prey Pooling	25416956
Intra	USP2	O75604	DTX3	Homo sapiens	Q8N9I9	Y2H Array	32296183
Intra	USP2	O75604	DTX3	Homo sapiens	Q8N9I9	Y2H Prey Pooling	32296183
Intra	USP2	O75604	DTX3	Homo sapiens	Q8N9I9	Validated Y2H	32296183
Intra	USP2	O75604	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	32296183
Intra	USP2	O75604	EFHC2	Homo sapiens	Q5JST6	Y2H Array	32296183
Intra	USP2	O75604	EFHC2	Homo sapiens	Q5JST6	Validated Y2H	32296183
Intra	USP2	O75604	JAKMIP1	Homo sapiens	Q96N16	Y2H Prey Pooling	32296183
Intra	USP2	O75604	JAKMIP1	Homo sapiens	Q96N16	Validated Y2H	32296183
Intra	USP2	O75604	JAKMIP1	Homo sapiens	Q96N16	Y2H Array	32296183
Intra	USP2	O75604	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	32296183
Intra	USP2	O75604	VPS52	Homo sapiens	Q8N1B4	Validated Y2H	32296183
Intra	USP2	O75604	VPS52	Homo sapiens	Q8N1B4	Y2H Array	25416956
Intra	USP2	O75604	VPS52	Homo sapiens	Q8N1B4	Y2H Array	32296183
Intra	USP2	O75604	VPS52	Homo sapiens	Q8N1B4	Validated Y2H	25416956
Intra	USP2	O75604	LMNB2	Homo sapiens	Q03252	Y2H Array	32296183
Intra	USP2	O75604	LMNB2	Homo sapiens	Q03252	Y2H Prey Pooling	32296183
Intra	USP2	O75604	LMNB2	Homo sapiens	Q03252	Validated Y2H	32296183
Intra	USP2	O75604	LHX4	Homo sapiens	Q969G2	Y2H Array	25416956
Intra	USP2	O75604	LHX4	Homo sapiens	Q969G2	Y2H Array	31515488
Intra	USP2	O75604	ACTN3	Homo sapiens	Q08043	Y2H Array	32296183
Intra	USP2	O75604	ACTN3	Homo sapiens	Q08043	Y2H Prey Pooling	32296183
Intra	USP2	O75604	ACTN3	Homo sapiens	Q08043	Validated Y2H	32296183
Intra	USP2	O75604	EIF4ENIF1	Homo sapiens	Q9NRA8	Y2H Prey Pooling	32296183
Intra	USP2	O75604	EIF4ENIF1	Homo sapiens	Q9NRA8	Validated Y2H	32296183
Intra	USP2	O75604	EIF4ENIF1	Homo sapiens	Q9NRA8	Y2H Array	32296183
Intra	USP2	O75604	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	25416956
Intra	USP2	O75604	KRT27	Homo sapiens	Q7Z3Y8	Validated Y2H	32296183
Intra	USP2	O75604	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	USP2	O75604	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	USP2	O75604	CCDC88B	Homo sapiens	A6NC98	Y2H Array	32296183
Intra	USP2	O75604	CCDC88B	Homo sapiens	A6NC98	Y2H Prey Pooling	32296183
Intra	USP2	O75604	ACTN1	Homo sapiens	P12814	Validated Y2H	32296183
Intra	USP2	O75604	ACTN1	Homo sapiens	P12814	Y2H Prey Pooling	32296183
Intra	USP2	O75604	ACTN1	Homo sapiens	P12814	Y2H Array	32296183
Intra	USP2	O75604	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	USP2	O75604	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	25416956
Intra	USP2	O75604	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	USP2	O75604	TRAF2	Homo sapiens	Q12933	Validated Y2H	32296183
Intra	USP2	O75604	TRAF2	Homo sapiens	Q12933	Validated Y2H	25416956
Intra	USP2	O75604	GEMIN4	Homo sapiens	P57678	Validated Y2H	32296183
Intra	USP2	O75604	GEMIN4	Homo sapiens	P57678	Y2H Array	32296183
Intra	USP2	O75604	GEMIN4	Homo sapiens	P57678	Y2H Prey Pooling	32296183
Intra	USP2	O75604	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183
Intra	USP2	O75604	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183
Intra	USP2	O75604	TRAF1	Homo sapiens	Q13077	Validated Y2H	32296183
Intra	USP2	O75604	TRAF6	Homo sapiens	Q9Y4K3	Y2H Array	25416956
Intra	USP2	O75604	TRAF6	Homo sapiens	Q9Y4K3	Y2H Prey Pooling	25416956
Intra	USP2	O75604	EXOSC8	Homo sapiens	Q96B26	Y2H Array	32296183
Intra	USP2	O75604	EXOSC8	Homo sapiens	Q96B26	Validated Y2H	32296183
Intra	USP2	O75604	EXOSC8	Homo sapiens	Q96B26	Y2H Prey Pooling	32296183
Intra	USP2	O75604	MDM2	Homo sapiens	Q00987	Pull Down	17290220
Intra	USP2	O75604	PRDM14	Homo sapiens	Q9GZV8	Y2H Array	32296183
Intra	USP2	O75604	PRDM14	Homo sapiens	Q9GZV8	Y2H Prey Pooling	32296183
Intra	USP2	O75604	PRDM14	Homo sapiens	Q9GZV8	Validated Y2H	32296183
Intra	USP2	O75604	RABEP1	Homo sapiens	Q15276	Y2H Prey Pooling	32296183
Intra	USP2	O75604	RABEP1	Homo sapiens	Q15276	Validated Y2H	32296183
Intra	USP2	O75604	RABEP1	Homo sapiens	Q15276	Y2H Array	32296183
Intra	USP2	O75604	NEFL	Homo sapiens	P07196	Y2H Prey Pooling	32296183
Intra	USP2	O75604	NEFL	Homo sapiens	P07196	Validated Y2H	32296183
Intra	USP2	O75604	NEFL	Homo sapiens	P07196	Y2H Array	32296183
Intra	USP2	O75604	BIRC7	Homo sapiens	Q96CA5	Validated Y2H	32296183
Intra	USP2	O75604	BIRC7	Homo sapiens	Q96CA5	Y2H Prey Pooling	32296183
Intra	USP2	O75604	BIRC7	Homo sapiens	Q96CA5	Y2H Array	32296183
Intra	USP2	O75604	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	USP2	O75604	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	USP2	O75604	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	USP2	O75604	TAX1BP1	Homo sapiens	Q86VP1	Y2H Prey Pooling	32296183
Intra	USP2	O75604	TAX1BP1	Homo sapiens	Q86VP1	Y2H Array	32296183
Intra	USP2	O75604	TAX1BP1	Homo sapiens	Q86VP1	Validated Y2H	32296183
Intra	USP2	O75604	OIP5	Homo sapiens	O43482	Y2H Prey Pooling	32296183
Intra	USP2	O75604	OIP5	Homo sapiens	O43482	Y2H Array	32296183
Intra	USP2	O75604	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	USP2	O75604	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	USP2	O75604	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	USP2	O75604	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	USP2	O75604	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	USP2	O75604	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
Intra	USP2	O75604	BCAR1	Homo sapiens	P56945	Y2H Prey Pooling	32296183
Intra	USP2	O75604	BCAR1	Homo sapiens	P56945	Validated Y2H	32296183
Intra	USP2	O75604	BCAR1	Homo sapiens	P56945	Y2H Array	32296183
Intra	USP2	O75604	S100A10	Homo sapiens	P60903	Validated Y2H	32296183
Intra	USP2	O75604	S100A10	Homo sapiens	P60903	Y2H Array	32296183
Intra	USP2	O75604	S100A10	Homo sapiens	P60903	Y2H Prey Pooling	32296183
Intra	USP2	O75604	GRIPAP1	Homo sapiens	Q4V328	Y2H Prey Pooling	32296183
Intra	USP2	O75604	GRIPAP1	Homo sapiens	Q4V328	Validated Y2H	32296183
Intra	USP2	O75604	GRIPAP1	Homo sapiens	Q4V328	Y2H Array	32296183
Intra	USP2	O75604	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	USP2	O75604	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	USP2	O75604	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	USP2	O75604	TRIM27	Homo sapiens	P14373	Validated Y2H	32296183
Intra	USP2	O75604	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	USP2	O75604	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	USP2	O75604	MRPL28	Homo sapiens	Q13084	Y2H Prey Pooling	32296183
Intra	USP2	O75604	MRPL28	Homo sapiens	Q13084	Validated Y2H	32296183
Intra	USP2	O75604	MRPL28	Homo sapiens	Q13084	Y2H Array	32296183
Intra	USP2	O75604	DUSP21	Homo sapiens	Q9H596	Validated Y2H	32296183
Intra	USP2	O75604	DUSP21	Homo sapiens	Q9H596	Y2H Array	32296183
Intra	USP2	O75604	DUSP21	Homo sapiens	Q9H596	Y2H Prey Pooling	32296183
Intra	USP2	O75604	KRT15	Homo sapiens	P19012	Y2H Array	25416956
Intra	USP2	O75604	KRT15	Homo sapiens	P19012	Validated Y2H	25416956
Intra	USP2	O75604	KRT15	Homo sapiens	P19012	Pull Down	16189514
Intra	USP2	O75604	CALCOCO2	Homo sapiens	Q13137	Validated Y2H	32296183
Intra	USP2	O75604	CALCOCO2	Homo sapiens	Q13137	Y2H Array	32296183
Intra	USP2	O75604	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	32296183
Intra	USP2	O75604	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	USP2	O75604	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	USP2	O75604	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	32296183
Intra	USP2	O75604	CRACR2A	Homo sapiens	Q9BSW2	Validated Y2H	32296183
Intra	USP2	O75604	CRACR2A	Homo sapiens	Q9BSW2	Y2H Array	32296183
Intra	USP2	O75604	CRACR2A	Homo sapiens	Q9BSW2	Y2H Prey Pooling	32296183
Intra	USP2	O75604	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	32296183
Intra	USP2	O75604	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	32296183
Intra	USP2	O75604	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	32296183
Intra	USP2	O75604	ZBED1	Homo sapiens	O96006	Y2H Prey Pooling	32296183
Intra	USP2	O75604	ZBED1	Homo sapiens	O96006	Validated Y2H	32296183
Intra	USP2	O75604	ZBED1	Homo sapiens	O96006	Y2H Array	32296183
Intra	USP2	O75604	TRIM23	Homo sapiens	P36406	Validated Y2H	32296183
Intra	USP2	O75604	TRIM23	Homo sapiens	P36406	Y2H Array	32296183
Intra	USP2	O75604	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	32296183
Intra	USP2	O75604	DYDC1	Homo sapiens	Q8WWB3	Y2H Prey Pooling	32296183
Intra	USP2	O75604	DYDC1	Homo sapiens	Q8WWB3	Validated Y2H	32296183
Intra	USP2	O75604	DYDC1	Homo sapiens	Q8WWB3	Y2H Array	32296183
Intra	USP2	O75604	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
Intra	USP2	O75604	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	32296183
Intra	USP2	O75604	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	25416956
Intra	USP2	O75604	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	32296183
Intra	USP2	O75604	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
Intra	USP2	O75604	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	32296183
Intra	USP2	O75604	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	32296183
Intra	USP2	O75604	SORBS3	Homo sapiens	O60504	Y2H Array	32296183
Intra	USP2	O75604	TRIP6	Homo sapiens	Q15654	Validated Y2H	32296183
Intra	USP2	O75604	TRIP6	Homo sapiens	Q15654	Y2H Prey Pooling	32296183
Intra	USP2	O75604	TRIP6	Homo sapiens	Q15654	Y2H Array	32296183
Intra	USP2	O75604	MTUS2	Homo sapiens	Q5JR59	Y2H Array	25416956
Intra	USP2	O75604	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
Intra	USP2	O75604	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
Intra	USP2	O75604	RFX6	Homo sapiens	Q8HWS3	Validated Y2H	32296183
Intra	USP2	O75604	RFX6	Homo sapiens	Q8HWS3	Y2H Array	32296183
Intra	USP2	O75604	RFX6	Homo sapiens	Q8HWS3	Y2H Prey Pooling	32296183
Intra	USP2	O75604	HOOK1	Homo sapiens	Q9UJC3	Validated Y2H	25416956
Intra	USP2	O75604	HOOK1	Homo sapiens	Q9UJC3	Y2H Array	25416956
Intra	USP2	O75604	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	32296183
Intra	USP2	O75604	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	32296183
Intra	USP2	O75604	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	32296183
Intra	USP2	O75604	DDI1	Homo sapiens	Q8WTU0	Validated Y2H	32296183
Intra	USP2	O75604	DDI1	Homo sapiens	Q8WTU0	Y2H Prey Pooling	32296183
Intra	USP2	O75604	DDI1	Homo sapiens	Q8WTU0	Y2H Array	32296183
Intra	USP2	O75604	INTS11	Homo sapiens	Q5TA45	Y2H Array	32296183
Intra	USP2	O75604	INTS11	Homo sapiens	Q5TA45	Y2H Prey Pooling	32296183
Intra	USP2	O75604	INTS11	Homo sapiens	Q5TA45	Validated Y2H	32296183
Intra	USP2	O75604	HOMER3	Homo sapiens	Q9NSC5	Validated Y2H	32296183
Intra	USP2	O75604	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	25416956
Intra	USP2	O75604	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	32296183
Intra	USP2	O75604	HOMER3	Homo sapiens	Q9NSC5	Y2H Prey Pooling	25416956
Intra	USP2	O75604	HOMER3	Homo sapiens	Q9NSC5	Validated Y2H	25416956
Intra	USP2	O75604	HOMER3	Homo sapiens	Q9NSC5	Y2H Prey Pooling	32296183
Intra	USP2	O75604	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32296183
Intra	USP2	O75604	OPTN	Homo sapiens	Q96CV9	Y2H Prey Pooling	32296183
Intra	USP2	O75604	OPTN	Homo sapiens	Q96CV9	Y2H Array	32296183
Intra	USP2	O75604	TEKT4	Homo sapiens	Q8WW24	Validated Y2H	32296183
Intra	USP2	O75604	TEKT4	Homo sapiens	Q8WW24	Y2H Prey Pooling	32296183
Intra	USP2	O75604	TEKT4	Homo sapiens	Q8WW24	Y2H Array	32296183
Intra	USP2	O75604	ACTN2	Homo sapiens	P35609	Validated Y2H	32296183
Intra	USP2	O75604	ACTN2	Homo sapiens	P35609	Y2H Array	32296183
Intra	USP2	O75604	ACTN2	Homo sapiens	P35609	Y2H Prey Pooling	32296183
Intra	USP2	O75604	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	USP2	O75604	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	USP2	O75604	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	USP2	O75604	TNFAIP2	Homo sapiens	Q03169	Y2H Prey Pooling	32296183
Intra	USP2	O75604	TNFAIP2	Homo sapiens	Q03169	Validated Y2H	32296183
Intra	USP2	O75604	TNFAIP2	Homo sapiens	Q03169	Y2H Array	32296183
Intra	USP2	O75604	IHO1	Homo sapiens	Q8IYA8	Validated Y2H	25416956
Intra	USP2	O75604	IHO1	Homo sapiens	Q8IYA8	Y2H Prey Pooling	25416956
Intra	USP2	O75604	NAB2	Homo sapiens	Q15742	Y2H Prey Pooling	32296183
Intra	USP2	O75604	NAB2	Homo sapiens	Q15742	Y2H Array	32296183
Intra	USP2	O75604	NAB2	Homo sapiens	Q15742	Validated Y2H	32296183
Intra	USP2	O75604	NDEL1	Homo sapiens	Q9GZM8	Y2H Prey Pooling	32296183
Intra	USP2	O75604	NDEL1	Homo sapiens	Q9GZM8	Validated Y2H	25416956
Intra	USP2	O75604	NDEL1	Homo sapiens	Q9GZM8	Validated Y2H	32296183
Intra	USP2	O75604	NDEL1	Homo sapiens	Q9GZM8	Y2H Array	32296183
Intra	USP2	O75604	NDEL1	Homo sapiens	Q9GZM8	Y2H Prey Pooling	25416956
Intra	USP2	O75604	POU2AF1	Homo sapiens	Q16633	Y2H Prey Pooling	32296183
Intra	USP2	O75604	POU2AF1	Homo sapiens	Q16633	Validated Y2H	32296183
Intra	USP2	O75604	POU2AF1	Homo sapiens	Q16633	Y2H Array	32296183
Intra	USP2	O75604	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	USP2	O75604	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	USP2	O75604	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	USP2	O75604	PLEKHG4	Homo sapiens	Q58EX7	Y2H Array	32296183
Intra	USP2	O75604	PLEKHG4	Homo sapiens	Q58EX7	Y2H Prey Pooling	32296183
Intra	USP2	O75604	PLEKHG4	Homo sapiens	Q58EX7	Validated Y2H	32296183
Intra	USP2	O75604	EXOC5	Homo sapiens	O00471	Y2H Prey Pooling	32296183
Intra	USP2	O75604	EXOC5	Homo sapiens	O00471	Y2H Array	32296183
Intra	USP2	O75604	TRIM50	Homo sapiens	Q86XT4	Y2H Prey Pooling	32296183
Intra	USP2	O75604	TRIM50	Homo sapiens	Q86XT4	Validated Y2H	32296183
Intra	USP2	O75604	TRIM50	Homo sapiens	Q86XT4	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant USP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79457	USP2 Catalytic Domain Protein, Human (His)	O75604-1 (N259-M605)	≥95%

Related Diseases

Diseases

Alias

Machado-Joseph Disease

SCA3	MJD
Spinocerebellar Ataxia 3	Azorean Disease
Spinocerebellar Ataxia Type 3	Spinocerebellar Atrophy
Azorean Neurologic Disease	Spinopontine Atrophy
Nigrospinodentatal Degeneration	Spinocerebellar Atrophy Iii
Spinocerebellar Atrophy Type 3	Azorean Ataxia
Azorean Disease Of The Nervous System	Machado Disease
Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia	Disease, Machado-Joseph
Ataxia, Spinocerebellar

Fasciitis

Liddle Syndrome 1

Liddle Syndrome	Pseudoaldosteronism
Liddle'S Syndrome	LIDLS1
Lidls	Pseudohyperaldosteronism
Pseudoprimary Hyperaldosteronism	Pseudohyperaldosteronism Type 1
Liddles Syndrome

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia	Adca
Pierre Marie Cerebellar Ataxia	Ataxia, Spinocerebellar
Sca	Autosomal Dominant Spinocerebellar Ataxia
Spinocerebellar Ataxias

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15530	USP2 Human Pre-designed siRNA Set A	Inhibitor	/	Unkown
HY-162312	LLK203	Inhibitor	98.58%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	USP2	RGD	RGD:621073
Macaca mulatta	USP2	VGNC	VGNC:101425
Felis catus	USP2	VGNC	VGNC:81096
Mus musculus	USP2	MGD	MGI:1858178
Bos taurus	USP2	VGNC	VGNC:54894
Others	USP2	NCBI

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