STK26 - serine/threonine kinase 26 Gene

Homo sapiens

Also known as MASK; MST4

Gene ID: 51765 | Gene type: protein coding

About STK26

Cytogenetic location: Xq26.2 Genomic coordinates (GRCh38): X:132,023,302-132,075,943 (from NCBI)

This gene has 5 transcripts (splice variants), 219 orthologues and 35 paralogues. Broad expression in endometrium (RPKM 22.0), bone marrow (RPKM 21.7) and 22 other tissues.

Summary

The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by Caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

STK26 Products(3)

mRNA	Protein	Name
NM_001042452.2	NP_001035917.1	serine/threonine-protein kinase 26 isoform 3
NM_001042453.2	NP_001035918.1	serine/threonine-protein kinase 26 isoform 2
NM_016542.4	NP_057626.2	serine/threonine-protein kinase 26 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	11641781	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	11741893	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	11641781	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15037601	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	21561863	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	11641781	GOA
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	22797597	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to oxidative stress	IDA IDA: Inferred from direct assay	22291017	GOA
involved in cellular response to starvation	IMP IMP: Inferred from mutant phenotype	27807006	GOA
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	22291017	GOA
involved in microvillus assembly	IDA IDA: Inferred from direct assay	22797597	GOA
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	27807006	GOA
involved in protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	22797597	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	11641781	GOA
involved in regulation of apoptotic process	IDA IDA: Inferred from direct assay	11741893	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of FAR/SIN/STRIPAK complex	IDA IDA: Inferred from direct assay	18782753	GOA
located in Golgi apparatus	IDA IDA: Inferred from direct assay	15037601	GOA
located in Golgi-associated vesicle	IDA IDA: Inferred from direct assay	22797597	GOA
located in apical plasma membrane	IDA IDA: Inferred from direct assay	22797597	GOA
located in cell periphery	IDA IDA: Inferred from direct assay	22291017	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17360971	GOA
located in cytosol	IDA IDA: Inferred from direct assay	22797597	GOA
located in membrane	IDA IDA: Inferred from direct assay	27807006	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	22291017	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STK26 Protein Structure

Pkinase

0
100
200
300
416 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase 26

Mst3 and SOK1-related kinase

Recombinant STK26 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74741	MST4/STK26 Protein, Human (sf9, GST)	Q9P289-1 (M1-P416)	≥95%

Related Diseases

Diseases

Alias

Cerebral Cavernous Malformations 3

Cerebral Cavernous Malformation 3	CCM3
Cerebral Cavernous Malformations-3	Cavernous Angiomatous Malformations
Cavernous Hemangioma Of The Brain	Cerebral Capillary Malformations
Cerebral Cavernoma	Familial Cavernous Angioma
Cerebral Cavernous Malformations, Type 3

Cerebral Cavernous Malformations

Cerebral Cavernous Malformation	Cavernous Malformations Of Cns And Retina
Cerebral Cavernous Malformation 1	Cavernous Angiomatous Malformations
Cerebral Capillary Malformations	CCM
Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations	Familial Cavernous Angioma
Cavernous Angioma	Familial Cerebral Cavernous Malformation
Cerebral Cavernous Malformations 1	Cavernous Angioma, Familial
Cam	Cerebral Cavernous Malformations-1
Cavernoma	Central Nervous System Cavernous Hemangioma
Cerebral Cavernous Hemangioma	Familial Cavernous Hemangioma
Familial Cavernous Malformation	Familial Cerebral Cavernous Angioma
Intracerebral Cavernous Hemangioma	CCM1
Cavernous Hemangioma Of The Brain	Cerebral Cavernoma
Cerebral Cavernous Malformations, Type 1	Hemangioma, Cavernous, Central Nervous System
Hemangioma, Cavernous	Angioma, Cavernous

Cerebrocostomandibular Syndrome

Cerebro-Costo-Mandibular Syndrome	CCMS
Rib Gap Defects With Micrognathia	Ccm Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13929	STK26 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	STK26	VGNC	VGNC:81585
Mus musculus	STK26	MGD	MGI:1917665
Rattus norvegicus	STK26	RGD	RGD:1563568
Canis familiaris	STK26	VGNC	VGNC:46910
Felis catus	STK26	VGNC	VGNC:97648
Bos taurus	STK26	VGNC	VGNC:35392
Others	STK26	NCBI

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