Sstr2 - somatostatin receptor 2 Gene

Rattus norvegicus

Also known as Smstr2

Gene ID: 54305 | Gene type: protein coding

About Sstr2

Primary_assembly 10: 98,664,216-98,674,351 forward strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 264 orthologues, 14 paralogues and is associated with 7 phenotypes. Biased expression in Adrenal (RPKM 48.4), Brain (RPKM 31.2) and 3 other tissues.

Summary

Enables PDZ domain binding activity and Somatostatin Receptor activity. Involved in several processes, including brain development; cellular response to lipid; and peristalsis. Located in cytoplasm and plasma membrane. Orthologous to human SSTR2 (Somatostatin Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Sstr2 Products(1)

mRNA	Protein	Name
NM_019348.2	NP_062221.1	somatostatin receptor type 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	10551867	RGD
enables somatostatin receptor activity	IDA IDA: Inferred from direct assay	1374909	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to estradiol stimulus	IEP IEP: Inferred from expression pattern	9564833	RGD
involved in cellular response to glucocorticoid stimulus	IEP IEP: Inferred from expression pattern	14512709	RGD
involved in cerebellum development	IEP IEP: Inferred from expression pattern	9166718	RGD
involved in forebrain development	IEP IEP: Inferred from expression pattern	10805921	RGD
involved in peristalsis	IMP IMP: Inferred from mutant phenotype	12504886	RGD
involved in response to starvation	IEP IEP: Inferred from expression pattern	7956902	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	9421433	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sstr2 Protein Structure

7tmA_SSTR2

0
100
200
300
369 a.a.

Protein Preferred Names

Protein Names

somatostatin receptor type 2

SRIF-1	SS-2-R
SS2-R	SS2R
somatostatin receptor subtype 2	somatotropin release-inhibiting factor receptor

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0036	Octreotide	Agonist	99.64%	Unkown
HY-P0036B	Octreotide pamoate	Agonist	/	Unkown

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P5362	NODAGA-LM3	Antagonist	99.33%	Phase 2
HY-P0024	Veldoreotide	Activator	/	Phase 2
HY-P10137	Satoreotide	Antagonist	98.88%	Phase 2
HY-P5362A	NODAGA-LM3 TFA	Antagonist	/	Phase 2
HY-P3294	Onzigolide	Agonist	/	Phase 2
HY-106103	Seglitide	Agonist	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1932	Cortistatin-14		99.21%	Unkown
HY-P1202A	CYN 154806 TFA	Antagonist	99.81%	Unkown
HY-P1202	CYN 154806	Antagonist	99.76%	Unkown
HY-P3124A	BIM-23190 hydrochloride	Agonist	99.64%	Unkown
HY-P4452	PRL 2915	Antagonist	99.57%	Unkown
HY-P3618	Cortistatin-29 (reduced)		98.12%	Unkown
HY-P0024A	Veldoreotide TFA	Agonist	98.37%	Unkown
HY-P4469	PRL 3195	Antagonist	/	Unkown
HY-P2545	[Tyr1]-Somatostatin-14		/	Unkown
HY-110161	sst2 Receptor agonist-1	Agonist	/	Unkown
HY-P3124	BIM-23190	Agonist	/	Unkown
HY-P2434	AP102		/	Unkown
HY-P2150	Cortistatin-29		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sstr2	NCBI	NCBI:6752

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