SSTR2 - somatostatin receptor 2 Gene

Homo sapiens

Also known as SST2

Gene ID: 6752 | Gene type: protein coding

About SSTR2

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:73,165,010-73,176,633 (from NCBI)

This gene has 2 transcripts (splice variants), 264 orthologues and 17 paralogues. Biased expression in brain (RPKM 12.7), adrenal (RPKM 3.5) and 10 other tissues.

Summary

Somatostatin acts at many sites to inhibit the release of many Hormones and Other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008]

SSTR2 Products(1)

mRNA	Protein	Name
NM_001050.3	NP_001041.1	somatostatin receptor type 2

SSTR2 Protein Structure

7tm_1

0
100
200
300
369 a.a.

Protein Preferred Names

Protein Names

somatostatin receptor type 2

SRIF-1

SS2R

SSTR2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SSTR2	P30874	SSTR3	Homo sapiens	P32745	Anti Tag CoIP	22651821
Intra	SSTR2	P30874	SSTR3	Homo sapiens	P32745	FRET	22651821
Intra	SSTR2	P30874	PIK3R1	Homo sapiens	P27986	Pull Down	16917505

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SSTR2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700430	SSTR2 Protein-VLP, Human (HEK293, His)	P30874 (M1-I369)	≥95%

Related Diseases

Diseases

Alias

Acth-Secreting Pituitary Adenoma

Acth-Producing Pituitary Adenoma	Corticotroph Adenoma
Corticotropinoma	Pituitary-Dependent Cushing'S Disease
Adrenal Gland Hyperfunction	Cushing Syndrome

Gastrointestinal Neuroendocrine Tumor

Gastrointestinal Neuroendocrine Tumour	Malignant Gastrointestinal Neuroendocrine Tumor
Malignant Gastrointestinal Neuroendocrine Tumour	Digestive System Neuroendocrine Neoplasm
Digestive System Neuroendocrine Tumor

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Pulmonary Neuroendocrine Tumor

Neuroendocrine Neoplasm Of Lung

Skull Base Cancer

Tumors Of Skull Base

Skull Base Neoplasms

Paraganglioma

Chemodectoma	Glomus Body Tumor
Paragangliomas	Carotid Body Paraganglioma
Extra-Adrenal Paraganglioma

Hormone Producing Pituitary Cancer

Growth Hormone Producing Pituitary Tumor	Pituitary Tumors, Hormone Producing
Somatotropinoma	Growth Hormone-Producing Pituitary Gland Neoplasm

Prolactinoma

Prolactin-Producing Pituitary Gland Adenoma	Prolactin-Secreting Pituitary Adenoma
Forbes-Albright Syndrome	Lactotroph Adenoma
Prl-Secreting Pituitary Adenoma	Prloma
Pituitary Lactotrophic Adenoma	Familial Prolactinoma
Pituitary Adenoma, Prolactin-Secreting	Prolactinoma Of Pituitary Gland
PSPA

Pituitary Carcinoma

Pituitary Cancer	Carcinoma Of The Pituitary Gland
Malignant Neoplasm Of Pituitary Gland

Intracranial Meningioma

Meningioma

Endocrine Organ Benign Neoplasm

Solitary Fibrous Tumor/Hemangiopericytoma

Sft/Hpc

Hyperinsulinemic Hypoglycemia

Nesidioblastosis	Islet Cell Hyperplasia
Persistent Hyperinsulinemia Hypoglycemia Of Infancy	Hyperinsulinemic Hypoglycaemia

Microcystic Meningioma

Optic Nerve Neoplasm

Optic Nerve Neoplasms	Neoplasm Of Optic Nerve
Tumor Of Second Cranial Nerve	Tumour Of Optic Nerve

Functioning Pituitary Adenoma

Secretory Adenoma Of The Pituitary Gland	Endocrine Active Pituitary Adenoma
Secreting Pituitary Adenoma	Pituitary Adenoma, Functioning

Pituitary Gland Disease

Pituitary Diseases	Pituitary Dysfunction
Pituitary Disease	Pituitary Deficiency
Pituitary Disorders

Thyroid Gland Medullary Carcinoma

Medullary Thyroid Carcinoma	Medullary Carcinoma Of The Thyroid Gland
Ultimobranchial Thyroid Tumor	Ultimobranchial Thyroid Tumour
Thyroid Cancer, Medullary

Thyroid Gland Cancer

Thyroid Gland Carcinoma	Malignant Neoplasm Of Thyroid Gland
Malignant Tumour Of Thyroid Gland	Thyroid Neoplasm
Thyroid Neoplasms	Neoplasm Of Thyroid Gland
Thyroid Gland Neoplasm	Head And Neck Cancer, Thyroid
Neoplasm Of The Thyroid Gland	Cancer Of The Thyroid
Primary Malignant Neoplasm Of Thyroglossal Duct	Malignant Neoplasm Of Thyroglossal Duct
Primary Malignant Neoplasm Of Thyroid Gland	Thyroglossal Duct Cancer
Toxic Goitre Malignant Tumour	Cancerous Goitre

Hyperpituitarism

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Desmoplastic/Nodular Medulloblastoma	Medulloblastoma With Extensive Nodularity
Desmoplastic Medulloblastoma	Medulloblastoma, Somatic
Medulloblastoma, Desmoplastic	Brain Medulloblastoma
Cns Pnet	Infratentorial Primitive Neuroectodermal Tumor
Mben	Medulloblastoma Desmoplastic
Neuroectodermal Tumors, Primitive	Medulloblastomas
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Growth Hormone Secreting Pituitary Adenoma

Somatotroph Adenoma	Growth Hormone-Secreting Pituitary Adenoma
Growth Hormone Producing Adenoma Of The Pituitary	Growth Hormone Secreting Adenoma Of Pituitary

Esophageal Neuroendocrine Tumor

Esophageal Neuroendocrine Tumour	Neuroendocrine Tumor Of Esophagus
Neuroendocrine Tumour Of Oesophagus

Adenoma

Acinar Cell Adenoma	Adenomas
Acinic Cell Adenoma

Skull Base Meningioma

Meningioma Of The Skull Base

Gastrinoma

Gastrin Cell Tumour	Gastrin Secreting Tumor
Malignant Gastrinoma	Gastrinoma, Malignant

Somatostatinoma

Somatostatin Cell Neoplasm	Somatostatin Cell Tumour
Ampullary Somatostatinoma	Carcinoid Somatostatinoma
Malignant Islet Cell Tumor	Somatomedin-Secreting Carcinoid
Somatostatin-Secreting Pancreatic Neoplasm	Pancreatic Somatostatinoma
Pancreatic Endocrine Carcinoma

Pituitary Adenoma

Pituitary Neoplasms	Adenoma Of The Pituitary Gland
Pituitary Adenomas	Adenoma, Pituitary
Pituitary Gland Adenoma

Insulinoma

Islet Cell Adenoma	Insulin-Producing Tumor Of Islet Cells
Adenoma Islet Cell	Islet Cell Tumor
Experimental Organism Islet Cell Adenoma Neoplasm

Pancreatic Cancer

Pancreatic Carcinoma	Familial Pancreatic Carcinoma
Pancreatic Neoplasm	Carcinoma Of Pancreas
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Pancreatic Carcinoma, Somatic	Pancreatic Cancer, Somatic
Ca Body Of Pancreas	Ca Head Of Pancreas
Ca Tail Of Pancreas	Malignant Neoplasm Of Body Of Pancreas
Malignant Neoplasm Of Head Of Pancreas	Malignant Neoplasm Of Tail Of Pancreas
Pancreas Neoplasm	Exocrine Cancer
Exocrine Pancreas Carcinoma	Hereditary Pancreatic Cancer
Hereditary Pancreatic Carcinoma	PNCA
Cancer Of The Pancreas	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Neuroendocrine Tumor

Neuroendocrine Neoplasm	Neuroendocrine Tumors
Carcinoma, Neuroendocrine

Polycystic Liver Disease

Autosomal Dominant Polycystic Liver Disease	Isolated Polycystic Liver Disease
Pcld	Congenital Cystic Liver Disease
Congenital Hepatic Cyst	Fibrocystic Liver Disease
Isolated Autosomal Dominant Polycystic Liver Disease	Adpcld
Liver Disease, Polycystic	Multiple Cysts Of Liver
Pld - [Polycystic Liver Disease]	Polycystic Liver Disorder
Polycystic Liver	Congenital Polycystic Disease Of Liver
Congenital Polycystic Liver Disease

Meningothelial Meningioma

Meningotheliomatous Meningioma

Optic Nerve Sheath Meningioma

Meningioma Of Optic Nerve Sheath

Endocrine Pancreas Disease

Disorder Of Endocrine Pancreas

Multiple Endocrine Neoplasia, Type I

Multiple Endocrine Neoplasia Type 1	MEN1
Wermer Syndrome	Multiple Endocrine Neoplasia 1
Multiple Endocrine Neoplasia, Type 1	Men I
Endocrine Adenomatosis, Multiple	Mea I
Men Type I	Wermer'S Syndrome
Men1 Syndrome	Multiple Endocrine Adenomatosis
Endocrine Adenomatosis Multiple	Men 1
Familial Multiple Endocrine Neoplasia Type I	Neoplasia, Endocrine, Multiple, Type 1
Multiple Endocrine Neoplasia

Sudden Infant Death Syndrome

SIDS	Sudden Infant Death Syndrome, Susceptibility To
Cot Death	Crib Death
Sudden Death Of Nonspecific Cause In Infancy	Sudden Infant Death
Death, Sudden, Syndrome, Infant

Psammomatous Meningioma

Pancreatic Endocrine Carcinoma

Carcinoma Of Endocrine Pancreas	Islet Cell Carcinoma
Malignant Neoplasm Of Islets Of Langerhans	Pancreatic Neuroendocrine Carcinoma
Carcinoma Islet Cell	Carcinoma, Islet Cell

Pancreatic Cystadenoma

Cystadenoma Of Pancreas

Thyroid Carcinoma, Familial Medullary

Medullary Thyroid Carcinoma	Familial Medullary Thyroid Carcinoma
MTC	Fmtc
Mtc1	Thyroid Cancer, Medullary
Medullary Thyroid Cancer	Thyroid Carcinoma, Medullary
Familial Mtc	Thyroid Carcinoma Medullary
Carcinoma, Thyroid, Medullary, Familial	Medullary Carcinoma Of Thyroid
Medullary Carcinoma With Amyloid Stroma, Unspecified Site	Medullary Carcinoma With Amyloid Stroma Of Thyroid

Cranial Nerve Malignant Neoplasm

Cranial Nerve Neoplasms	Malignant Neoplasm Of Cranial Nerve
Malignant Tumor Of Cranial Nerve	Malignant Tumor Of The Cranial Nerve

Islet Cell Tumor

Pancreatic Neuroendocrine Tumor	Neuroendocrine Tumor Of Pancreas
Pnet	Pancreatic Net
Well-Differentiated Nen Of Pancreas	Well-Differentiated Neuroendocrine Neoplasm Of Pancreas
Well-Differentiated Pancreatic Nen	Well-Differentiated Pancreatic Neuroendocrine Neoplasm
Endocrine Pancreas Cancer	Islet Cell Neoplasm
Islet Cell Tumour	Malignant Pancreatic Endocrine Tumor
Malignant Pancreatic Endocrine Tumour	Malignant Tumor Of Endocrine Pancreas
Malignant Tumour Of Endocrine Pancreas	Pancreatic Endocrine Neoplasm
Pancreatic Endocrine Tumor	Pancreatic Neuroendocrine Neoplasm
Adenoma, Islet Cell	Well Differentiated Pancreatic Endocrine Tumor
Malignant Neoplasm Of Endocrine Pancreas	Pancreatic Endocrine Carcinoma

Acromegaly

Gigantism	Growth Hormone Excess
Pituitary Giant	Somatotroph Adenoma
Growth Hormone-Secreting Pituitary Adenoma

Carcinoid Tumors, Intestinal

Gastrointestinal Carcinoid Tumor	Argentaffinoma
Carcinoid	Intestinal Carcinoid Tumor
ICT	Tumor, Carcinoid, Intestinal
Malignant Carcinoid Syndrome	Carcinoid Tumor Of Intestine
Carcinoid Tumor	Carcinoid Tumor No Icd-O Subtype

Brain Meningioma

Intracranial Meningioma

Angiomatous Meningioma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0036	Octreotide	Agonist	99.64%	Unkown
HY-P0036B	Octreotide pamoate	Agonist	/	Unkown

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P5362	NODAGA-LM3	Antagonist	99.33%	Phase 2
HY-P0024	Veldoreotide	Activator	/	Phase 2
HY-P5362A	NODAGA-LM3 TFA	Antagonist	/	Phase 2
HY-P10137	Satoreotide	Antagonist	/	Phase 2
HY-P3294	Onzigolide	Agonist	/	Phase 2
HY-106103	Seglitide	Agonist	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1932	Cortistatin-14		99.21%	Unkown
HY-P1202A	CYN 154806 TFA	Antagonist	99.81%	Unkown
HY-P1202	CYN 154806	Antagonist	99.76%	Unkown
HY-P3124A	BIM-23190 hydrochloride	Agonist	99.64%	Unkown
HY-P4452	PRL 2915	Antagonist	99.57%	Unkown
HY-P3618	Cortistatin-29 (reduced)		99.22%	Unkown
HY-P0024A	Veldoreotide TFA	Agonist	98.37%	Unkown
HY-P4469	PRL 3195	Antagonist	/	Unkown
HY-P2545	[Tyr1]-Somatostatin-14		/	Unkown
HY-110161	sst2 Receptor agonist-1	Agonist	/	Unkown
HY-P3124	BIM-23190	Agonist	/	Unkown
HY-P2434	AP102		/	Unkown
HY-P2150	Cortistatin-29		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SSTR2	VGNC	VGNC:46844
Bos taurus	SSTR2	VGNC	VGNC:35326
Rattus norvegicus	SSTR2	RGD	RGD:3763
Macaca mulatta	SSTR2	VGNC	VGNC:77893
Felis catus	SSTR2	VGNC	VGNC:65711
Mus musculus	SSTR2	MGD	MGI:98328
Others	SSTR2	NCBI