SHFL - shiftless antiviral inhibitor of ribosomal frameshifting Gene

Homo sapiens

Also known as SFL; IRAV; RyDEN; C19orf66

Gene ID: 55337 | Gene type: protein coding

About SHFL

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,086,317-10,093,243 (from NCBI)

This gene has 11 transcripts (splice variants) and 136 orthologues. Ubiquitous expression in liver (RPKM 17.9), spleen (RPKM 17.5) and 25 other tissues.

Summary

This gene is an interferon stimulated gene (ISG) that inhibits viral replication. The encoded protein binds nucleic acids and inhibits programmed -1 ribosomal frameshifting required for translation by many RNA viruses. Viruses inhibited by the protein include Zika virus, Dengue virus and the coronaviruses, SARS-CoV and SARS-CoV2. [provided by RefSeq, Aug 2021]

SHFL Products(2)

mRNA	Protein	Name
NM_001308277.2	NP_001295206.1	shiftless antiviral inhibitor of ribosomal frameshifting protein isoform 2
NM_018381.4	NP_060851.2	shiftless antiviral inhibitor of ribosomal frameshifting protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	26735137	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA
enables ribosome binding	IDA IDA: Inferred from direct assay	30682371	GOA
enables sequence-specific mRNA binding	IDA IDA: Inferred from direct assay	30682371	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in defense response to virus	IDA IDA: Inferred from direct assay	26735137	GOA
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	27974568	GOA
involved in negative regulation of translational frameshifting	IDA IDA: Inferred from direct assay	30682371	GOA
involved in negative regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	26735137	GOA
involved in regulation of translational termination	IDA IDA: Inferred from direct assay	30682371	GOA
involved in response to interferon-beta	IDA IDA: Inferred from direct assay	27974568	GOA
involved in response to type I interferon	IDA IDA: Inferred from direct assay	26735137	GOA
involved in response to type II interferon	IDA IDA: Inferred from direct assay	26735137	GOA
involved in response to type III interferon	IDA IDA: Inferred from direct assay	26735137	GOA
involved in viral translational frameshifting	IDA IDA: Inferred from direct assay	30682371	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in P-body	IDA IDA: Inferred from direct assay	27974568	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	26735137	GOA
located in nucleus	IDA IDA: Inferred from direct assay	26735137	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SHFL Protein Structure

UPF0515

0
100
200
291 a.a.

Protein Preferred Names

Protein Names

shiftless antiviral inhibitor of ribosomal frameshifting protein

Repressor of yield of Dengue virus

SHFL Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SHFL	Q9NUL5	CCDC136	Homo sapiens	Q96JN2-2	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	CCDC136	Homo sapiens	Q96JN2-2	Y2H Array	25416956
Intra	SHFL	Q9NUL5	CCDC136	Homo sapiens	Q96JN2-2	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	KRTAP10-7	Homo sapiens	P60409	Y2H Array	25416956
Intra	SHFL	Q9NUL5	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Array	25416956
Intra	SHFL	Q9NUL5	KRTAP4-2	Homo sapiens	Q9BYR5	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	25416956
Intra	SHFL	Q9NUL5	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	25416956
Intra	SHFL	Q9NUL5	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	CADPS	Homo sapiens	A2RRN7	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	KRTAP2-3	Homo sapiens	P0C7H8	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	KRTAP2-3	Homo sapiens	P0C7H8	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	DRICH1	Homo sapiens	Q6PGQ1	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Array	25416956
Intra	SHFL	Q9NUL5	PDE4DIP	Homo sapiens	Q5VU43	Y2H Array	25416956
Intra	SHFL	Q9NUL5	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	KRTAP5-9	Homo sapiens	P26371	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	KRTAP5-9	Homo sapiens	P26371	Y2H Array	25416956
Intra	SHFL	Q9NUL5	DTNBP1	Homo sapiens	Q96EV8	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	DTNBP1	Homo sapiens	Q96EV8	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	TCF4	Homo sapiens	P15884	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	TERF1	Homo sapiens	P54274	Pull Down	21044950
Intra	SHFL	Q9NUL5	TERF1	Homo sapiens	P54274	BiFC	21044950
Intra	SHFL	Q9NUL5	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	KRTAP4-12	Homo sapiens	Q9BQ66	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	MAGEA1	Homo sapiens	P43355	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	MAGEA1	Homo sapiens	P43355	Y2H Array	25416956
Intra	SHFL	Q9NUL5	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	IKZF1	Homo sapiens	Q13422	Y2H Array	25416956
Intra	SHFL	Q9NUL5	IKZF1	Homo sapiens	Q13422	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956
Intra	SHFL	Q9NUL5	TNS2	Homo sapiens	Q63HR2	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	TNS2	Homo sapiens	Q63HR2	Y2H Array	25814554
Intra	SHFL	Q9NUL5	TNS2	Homo sapiens	Q63HR2	Y2H Array	25416956
Intra	SHFL	Q9NUL5	TNS2	Homo sapiens	Q63HR2	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hereditary Sensory And Autonomic Neuropathy Type 1

Hereditary Sensory And Autonomic Neuropathy Type I	Hereditary Sensory Neuropathy-Deafness-Dementia Syndrome
Hsan1e	Hsan1
Dnmt1-Related Dementia, Deafness, And Sensory Neuropathy	Hsn1e
Hsnie	Hereditary Sensory Neuropathy Type Ie
Hereditary Sensory Neuropathy-Sensorineural Hearing Loss-Dementia Syndrome	Hereditary Sensory And Autonomic Neuropathy Type Ie
Hereditary Sensory And Autonomic Neuropathy Type 1e	Hereditary Sensory Neuropathy With Hearing Loss And Dementia
Dnmt1-Complex Disorder	Hereditary Sensory And Autonomic Neuropathy Type 1 With Dementia And Hearing Loss
Hsn Ie	Hereditary Sensory Autonomic Neuropathy, Type 1
Hsan1- [Hereditary Sensory And Autonomic Neuropathy Type I]

Neuropathy, Hereditary Sensory, Type Ie

HSN1E	Hsn Ie
Hereditary Sensory Neuropathy Type 1e	Hereditary Sensory Neuropathy Type Ie
Hsan 1	Neuropathy, Hereditary Sensory, With Hearing Loss And Dementia
Hereditary Sensory Neuropathy Type 1	Hsn1
Hereditary Sensory And Autonomic Neuropathy Type 1	Neuropathy Hereditary Sensory And Autonomic Type 1
Neuropathy Hereditary Sensory Radicular, Autosomal Dominant	Neuropathy, Hereditary Sensory, 1e
Neuropathy Hereditary Sensory With Hearing Loss And Dementia	Neuropathy, Hereditary Sensory, Type I
Neuropathy, Sensory, Hereditary, Type Ie	Hereditary Sensory And Autonomic Neuropathy Type Ie
Hereditary Sensory Autonomic Neuropathy, Type 1

Dengue Virus

Dengue Virus, Susceptibility To	Dengue Fever, Protection Against
Dengue Fever

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12864	SHFL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SHFL	VGNC	VGNC:77311
Bos taurus	SHFL	VGNC	VGNC:55202
Rattus norvegicus	SHFL	RGD	RGD:1565995
Mus musculus	SHFL	MGD	MGI:2441788
Canis familiaris	SHFL	VGNC	VGNC:52518

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