PRKCI - protein kinase C iota Gene

Homo sapiens

Also known as PKCI; DXS1179E; nPKC-iota

Gene ID: 5584 | Gene type: protein coding

About PRKCI

Cytogenetic location: 3q26.2 Genomic coordinates (GRCh38): 3:170,222,424-170,305,977 (from NCBI)

This gene has 7 transcripts (splice variants), 226 orthologues and 9 paralogues. Ubiquitous expression in stomach (RPKM 19.1), thyroid (RPKM 17.9) and 24 other tissues.

Summary

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced Apoptosis and therefore protects leukemia cells against drug-induced Apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]

PRKCI Products(3)

mRNA	Protein	Name
NM_002740.6	NP_002731.4	protein kinase C iota type
XM_047448574.1	XP_047304530.1	protein kinase C iota type isoform X1
XM_047448575.1	XP_047304531.1	protein kinase C iota type isoform X2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables diacylglycerol-dependent serine/threonine kinase activity	EXP EXP: Inferred from Experiment	12700136	GOA
enables phospholipid binding	IDA IDA: Inferred from direct assay	8226978	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11257119	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	11724794	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	8226978	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell-cell junction organization	IMP IMP: Inferred from mutant phenotype	11257119	GOA
involved in establishment or maintenance of epithelial cell apical/basal polarity	IDA IDA: Inferred from direct assay	11257119	GOA
involved in negative regulation of glial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	21419810	GOA
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	10467349	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	10467349	GOA
involved in positive regulation of endothelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	19327373	GOA
involved in positive regulation of glial cell proliferation	IMP IMP: Inferred from mutant phenotype	21419810	GOA
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	36250347	GOA
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	10467349	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	8226978	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of PAR polarity complex	IPI IPI: Inferred from physical interaction	11257119	GOA
located in cytosol	IDA IDA: Inferred from direct assay	11257119	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11260256	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKCI Protein Structure

PB1

C1_1

Pkinase

Pkinase_C

0
100
200
300
400
500
596 a.a.

Protein Preferred Names

Protein Names

protein kinase C iota type

PRKC-lambda/iota	aPKC-lambda/iota
atypical protein kinase C-lambda/iota

PRKCI Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRKCI	P41743	ELF3	Homo sapiens	P78545	Anti Bait CoIP	26977885
Intra	PRKCI	P41743	PARD6A	Homo sapiens	Q9NPB6-2	Validated Y2H	32296183
Intra	PRKCI	P41743	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	PRKCI	P41743	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	PRKCI	P41743	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	PRKCI	P41743	PRKCZ	Homo sapiens	Q05513	Anti Tag CoIP	31980649
Intra	PRKCI	P41743	PARD6B	Homo sapiens	Q9BYG5	Validated Y2H	25416956
Intra	PRKCI	P41743	PARD6B	Homo sapiens	Q9BYG5	Pull Down	11260256
Intra	PRKCI	P41743	PARD6B	Homo sapiens	Q9BYG5	Anti Tag CoIP	26496610
Intra	PRKCI	P41743	PARD6B	Homo sapiens	Q9BYG5	Validated Y2H	32296183
Intra	PRKCI	P41743	PARD6B	Homo sapiens	Q9BYG5	Anti Tag CoIP	35271311
Intra	PRKCI	P41743	PARD6B	Homo sapiens	Q9BYG5	Anti Tag CoIP	31980649
Intra	PRKCI	P41743	PARD6B	Homo sapiens	Q9BYG5	Anti Tag CoIP	14676191
Intra	PRKCI	P41743	PARD6B	Homo sapiens	Q9BYG5	Y2H	11260256
Intra	PRKCI	P41743	PARD6G	Homo sapiens	Q9BYG4	Anti Tag CoIP	31980649
Intra	PRKCI	P41743	PARD6G	Homo sapiens	Q9BYG4	Y2H	11260256
Intra	PRKCI	P41743	PARD6G	Homo sapiens	Q9BYG4	Anti Tag CoIP	14676191
Intra	PRKCI	P41743	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	14676191
Intra	PRKCI	P41743	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	31980649
Intra	PRKCI	P41743	SQSTM1	Homo sapiens	Q13501	Validated Y2H	32296183
Intra	PRKCI	P41743	SQSTM1	Homo sapiens	Q13501	Y2H Array	32296183
Intra	PRKCI	P41743	SQSTM1	Homo sapiens	Q13501	Anti Bait CoIP	20808283
Intra	PRKCI	P41743	SQSTM1	Homo sapiens	Q13501	Y2H Prey Pooling	32296183
Intra	PRKCI	P41743	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	14676191
Intra	PRKCI	P41743	RAC1	Homo sapiens	P63000	Pull Down	11260256
Intra	PRKCI	P41743	SOX2	Homo sapiens	P48431	Protein Kinase Assay	24525231
Intra	PRKCI	P41743	NACC1	Homo sapiens	Q96RE7	Y2H Prey Pooling	32296183
Intra	PRKCI	P41743	NACC1	Homo sapiens	Q96RE7	Validated Y2H	32296183
Intra	PRKCI	P41743	NACC1	Homo sapiens	Q96RE7	Y2H Array	32296183
Intra	PRKCI	P41743	CDC42	Homo sapiens	P60953	Anti Tag CoIP	14676191
Intra	PRKCI	P41743	CDC42	Homo sapiens	P60953	Pull Down	11260256
Intra	PRKCI	P41743	PARD6A	Homo sapiens	Q9NPB6	Anti Tag CoIP	14676191
Intra	PRKCI	P41743	PARD6A	Homo sapiens	Q9NPB6	Y2H Array	25416956
Intra	PRKCI	P41743	PARD6A	Homo sapiens	Q9NPB6	Y2H Pooling	16189514
Intra	PRKCI	P41743	PARD6A	Homo sapiens	Q9NPB6	Y2H	11260256
Intra	PRKCI	P41743	PARD6A	Homo sapiens	Q9NPB6	Y2H Prey Pooling	25416956
Intra	PRKCI	P41743	PARD3	Homo sapiens	Q8TEW0	Anti Tag CoIP	31980649
Intra	PRKCI	P41743	PARD3	Homo sapiens	Q8TEW0	Anti Tag CoIP	14676191

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRKCI Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74630	PKC iota Protein, Human (sf9, GST)	P41743 (M10-V596)	≥95%

Related Diseases

Diseases

Alias

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Hepatomas
Liver Neoplasm	Liver Carcinoma
Liver And Intrahepatic Biliary Tract Carcinoma	Malignant Hepatobiliary Neoplasm
Adult Primary Hepatocellular Carcinoma	Hepatoblastoma
Carcinoma Of Liver	Malignant Liver Tumour
Malignant Hepatic Tumour

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Protection Against	Lung Cancer, Susceptibility To
Adenocarcinoma Of Lung, Somatic	Nonsmall Cell Lung Cancer
Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11134	PRKCI Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11135	Prkci Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11136	Prkci Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PRKCI	VGNC	VGNC:69062
Mus musculus	PRKCI	MGD	MGI:99260
Bos taurus	PRKCI	VGNC	VGNC:33333
Canis familiaris	PRKCI	VGNC	VGNC:44982
Rattus norvegicus	PRKCI	RGD	RGD:620961
Macaca mulatta	PRKCI	VGNC	VGNC:84064
Others	PRKCI	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.