MYDGF - myeloid derived growth factor Gene

Homo sapiens

Also known as IL25; IL27; SF20; IL27w; C19orf10; R33729_1; EUROIMAGE1875335

Gene ID: 56005 | Gene type: protein coding

About MYDGF

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,657,545-4,670,342 (from NCBI)

This gene has 4 transcripts (splice variants) and 183 orthologues. Ubiquitous expression in colon (RPKM 37.2), prostate (RPKM 33.6) and 25 other tissues.

Summary

The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]

MYDGF Products(1)

mRNA	Protein	Name
NM_019107.4	NP_061980.1	myeloid-derived growth factor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	25581518	GOA
involved in positive regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	25581518	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	29954947	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	29954947	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	25581518	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYDGF Protein Structure

UPF0556

0
100
173 a.a.

Protein Preferred Names

Protein Names

myeloid-derived growth factor

UPF0556 protein C19orf10

MYDGF Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MYDGF	Q969H8	ACOT13	Homo sapiens	Q9NPJ3	Validated Y2H	32296183
Intra	MYDGF	Q969H8	ACOT13	Homo sapiens	Q9NPJ3	Y2H Prey Pooling	32296183
Intra	MYDGF	Q969H8	ACOT13	Homo sapiens	Q9NPJ3	Y2H Array	32296183
Intra	MYDGF	Q969H8	LCN2	Homo sapiens	P80188	Y2H Prey Pooling	32296183
Intra	MYDGF	Q969H8	LCN2	Homo sapiens	P80188	Y2H Array	32296183
Intra	MYDGF	Q969H8	HPCA	Homo sapiens	P84074	Y2H Array	32296183
Intra	MYDGF	Q969H8	HPCA	Homo sapiens	P84074	Y2H Prey Pooling	32296183
Intra	MYDGF	Q969H8	LDB2	Homo sapiens	O43679	Y2H Prey Pooling	32296183
Intra	MYDGF	Q969H8	LDB2	Homo sapiens	O43679	Y2H Array	32296183
Intra	MYDGF	Q969H8	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	MYDGF	Q969H8	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	MYDGF	Q969H8	SGTA	Homo sapiens	O43765	Validated Y2H	25416956
Intra	MYDGF	Q969H8	EIF3F	Homo sapiens	O00303	Y2H Prey Pooling	32296183
Intra	MYDGF	Q969H8	EIF3F	Homo sapiens	O00303	Y2H Array	32296183
Intra	MYDGF	Q969H8	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	MYDGF	Q969H8	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183
Intra	MYDGF	Q969H8	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
Intra	MYDGF	Q969H8	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	MYDGF	Q969H8	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	MYDGF	Q969H8	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	MYDGF	Q969H8	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	MYDGF	Q969H8	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	MYDGF	Q969H8	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	MYDGF	Q969H8	HPCAL1	Homo sapiens	P37235	Y2H Prey Pooling	32296183
Intra	MYDGF	Q969H8	HPCAL1	Homo sapiens	P37235	Y2H Array	32296183
Intra	MYDGF	Q969H8	HPCAL1	Homo sapiens	P37235	MAPPIT	32296183
Intra	MYDGF	Q969H8	NCALD	Homo sapiens	P61601	Y2H Prey Pooling	32296183
Intra	MYDGF	Q969H8	NCALD	Homo sapiens	P61601	Y2H Array	32296183
Intra	MYDGF	Q969H8	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	MYDGF	Q969H8	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	MYDGF	Q969H8	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	MYDGF	Q969H8	PDIA5	Homo sapiens	Q14554	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MYDGF Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70581	MYDGF Protein, Human (His)	Q969H8 (S33-L173)	≥95%
HY-P700641	SF20/MYDGF Protein, Human (HEK293, His)	Q969H8 (V32-L173)	≥95%

MYDGF Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82783	SF20 Antibody (YA2528)	WB	Human

Related Diseases

Diseases

Alias

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Heinz Body Anemias

Heinz Body Anemia	Heinz Body Anemias, Alpha-
HEIBAN	Anemia, Heinz Body
Acquired Heinz Body Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08889	MYDGF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MYDGF	MGD	MGI:2156020
Bos taurus	MYDGF	VGNC	VGNC:31790
Felis catus	MYDGF	VGNC	VGNC:63673
Rattus norvegicus	MYDGF	RGD	RGD:1589603
Canis familiaris	MYDGF	VGNC	VGNC:43532
Others	MYDGF	NCBI

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