METTL14 - methyltransferase 14, N6-adenosine-methyltransferase subunit Gene

Homo sapiens

Also known as hMETTL14

Gene ID: 57721 | Gene type: protein coding

About METTL14

Cytogenetic location: 4q26 Genomic coordinates (GRCh38): 4:118,685,392-118,715,430 (from NCBI)

This gene has 6 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in testis (RPKM 8.4), thyroid (RPKM 7.2) and 25 other tissues.

Summary

Enables mRNA binding activity. Contributes to mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity. Involved in mRNA metabolic process; negative regulation of hematopoietic progenitor cell differentiation; and positive regulation of translation. Located in nucleoplasm. Part of RNA N6-methyladenosine methyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

METTL14 Products(1)

mRNA	Protein	Name
NM_020961.4	NP_066012.1	N6-adenosine-methyltransferase non-catalytic subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables S-adenosyl-L-methionine binding	IDA IDA: Inferred from direct assay	27281194	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	27281194	GOA
NOT enables mRNA m(6)A methyltransferase activity	IDA IDA: Inferred from direct assay	27627798	GOA
enables mRNA m(6)A methyltransferase activity	IDA IDA: Inferred from direct assay	24316715	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24316715	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA modification	IDA IDA: Inferred from direct assay	27281194	GOA
involved in mRNA processing	IDA IDA: Inferred from direct assay	27281194	GOA
involved in mRNA processing	IMP IMP: Inferred from mutant phenotype	24316715	GOA
involved in mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	25719671	GOA
involved in mRNA stabilization	IDA IDA: Inferred from direct assay	29290617	GOA
acts upstream of negative regulation of hematopoietic progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	29290617	GOA
acts upstream of positive regulation of translation	IMP IMP: Inferred from mutant phenotype	29290617	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA N6-methyladenosine methyltransferase complex	IDA IDA: Inferred from direct assay	24316715	GOA
part of RNA N6-methyladenosine methyltransferase complex	IPI IPI: Inferred from physical interaction	29507755	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24316715	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METTL14 Protein Structure

MT-A70

0
100
200
300
400
456 a.a.

Protein Preferred Names

Protein Names

N6-adenosine-methyltransferase non-catalytic subunit

N6-adenosine-methyltransferase subunit METTL14

METTL14 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	METTL14	Q9HCE5	METTL3	Homo sapiens	Q86U44	GMS	27373337
Intra	METTL14	Q9HCE5	METTL3	Homo sapiens	Q86U44	Comig Non-Denat Gel	24316715
Intra	METTL14	Q9HCE5	METTL3	Homo sapiens	Q86U44	Pull Down	24394384
Intra	METTL14	Q9HCE5	METTL3	Homo sapiens	Q86U44	Anti Tag CoIP	33961781
Intra	METTL14	Q9HCE5	METTL3	Homo sapiens	Q86U44	Anti Tag CoIP	24316715
Intra	METTL14	Q9HCE5	METTL3	Homo sapiens	Q86U44	Anti Tag CoIP	29507755
Intra	METTL14	Q9HCE5	METTL3	Homo sapiens	Q86U44	X-Ray Diffraction	27373337
Intra	METTL14	Q9HCE5	METTL3	Homo sapiens	Q86U44-1	Anti Tag CoIP	24316715
Intra	METTL14	Q9HCE5	METTL3	Homo sapiens	Q86U44-1	GMS	24316715
Intra	METTL14	Q9HCE5	WTAP	Homo sapiens	Q15007-1	Anti Tag CoIP	24316715
Intra	METTL14	Q9HCE5	WTAP	Homo sapiens	Q15007-1	GMS	24316715

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hepatoblastoma

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19528	SAH		99.89%	Unkown
HY-160415A	WD6305 TFA		99.81%	Unkown
HY-19528S	SAH-d4		≥99.0%	Unkown
HY-153625	STM2120	Inhibitor	99.92%	Unkown
HY-RS08355	METTL14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-151926	Antiviral agent 24	Inhibitor	99.63%	Unkown
HY-19528S2	SAH-13C10		99.90%	Unkown
HY-P10387A	RSM3 TFA		/	Unkown
HY-151924	Antiviral agent 23	Inhibitor	/	Unkown
HY-160415	WD6305		/	Unkown
HY-162282	PROTAC METTL3-14 degrader 1	Degrader	/	Unkown
HY-19528S1	SAH-13C5		/	Unkown
HY-P10387	RSM3		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	METTL14	VGNC	VGNC:63459
Canis familiaris	METTL14	VGNC	VGNC:43171
Macaca mulatta	METTL14	VGNC	VGNC:74612
Mus musculus	METTL14	MGD	MGI:2442926
Bos taurus	METTL14	VGNC	VGNC:31404
Rattus norvegicus	METTL14	RGD	RGD:1304822
Others	METTL14	NCBI

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