SLAMF7 - SLAM family member 7 Gene

Homo sapiens

Also known as 19A; CS1; CD319; CRACC

Gene ID: 57823 | Gene type: protein coding

About SLAMF7

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:160,739,057-160,754,821 (from NCBI)

This gene has 11 transcripts (splice variants), 138 orthologues and 9 paralogues. Biased expression in lymph node (RPKM 22.3), appendix (RPKM 19.3) and 13 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in adaptive immune response. Predicted to act upstream of or within regulation of natural killer cell activation. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

SLAMF7 Products(10)

mRNA	Protein	Name
NM_001282588.2	NP_001269517.1	SLAM family member 7 isoform b precursor
NM_001282589.2	NP_001269518.1	SLAM family member 7 isoform c precursor
NM_001282590.2	NP_001269519.1	SLAM family member 7 isoform d
NM_001282591.2	NP_001269520.1	SLAM family member 7 isoform e
NM_001282592.2	NP_001269521.1	SLAM family member 7 isoform f precursor
NM_001282593.2	NP_001269522.1	SLAM family member 7 isoform g
NM_001282594.2	NP_001269523.1	SLAM family member 7 isoform h
NM_001282595.1	NP_001269524.1	SLAM family member 7 isoform i
NM_001282596.2	NP_001269525.1	SLAM family member 7 isoform j
NM_021181.5	NP_067004.3	SLAM family member 7 isoform a precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	15153464	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLAMF7 Protein Structure

V-set

Ig_3

0
100
200
300
335 a.a.

Protein Preferred Names

Protein Names

SLAM family member 7

19A24 protein

SLAMF7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLAMF7	Q9NQ25	SLAMF7	Homo sapiens	Q9NQ25	FACS	15153464
Intra	SLAMF7	Q9NQ25	MAK	Homo sapiens	P20794	Y2H Array	21988832
Intra	SLAMF7	Q9NQ25	CMTM6	Homo sapiens	Q9NX76	Anti Tag CoIP	33961781
Intra	SLAMF7	Q9NQ25	PTCD2	Homo sapiens	Q8WV60	Anti Tag CoIP	33961781
Intra	SLAMF7	Q9NQ25	SLAMF7	Homo sapiens	Q9NQ25	Protein Array	21982860
Intra	SLAMF7	Q9NQ25	NCR3	Homo sapiens	O14931	FACS	15153464
Intra	SLAMF7	Q9NQ25	SH2D1B	Homo sapiens	O14796	SPR	24642916
Intra	SLAMF7	Q9NQ25	TBC1D23	Homo sapiens	Q9NUY8	Anti Tag CoIP	33961781
Intra	SLAMF7	Q9NQ25	CLK3	Homo sapiens	P49761	Y2H Array	21988832
Intra	SLAMF7	Q9NQ25	HUS1	Homo sapiens	O60921	Anti Tag CoIP	33961781
Intra	SLAMF7	Q9NQ25	TNFSF9	Homo sapiens	P41273	Anti Tag CoIP	33961781
Intra	SLAMF7	Q9NQ25	CTNNB1	Homo sapiens	P35222	Anti Tag CoIP	33961781
Intra	SLAMF7	Q9NQ25	YIF1A	Homo sapiens	O95070	Anti Tag CoIP	33961781
Intra	SLAMF7	Q9NQ25	FBXO2	Homo sapiens	Q9UK22	Anti Tag CoIP	33961781
Intra	SLAMF7	Q9NQ25	SH2D1A	Homo sapiens	O60880	SPR	24642916
Intra	SLAMF7	Q9NQ25	NAGPA	Homo sapiens	Q9UK23	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SLAMF7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72416	CRACC/SLAMF7 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9NQ25-1 (S23-M226)	≥95%
HY-P72460	CRACC/SLAMF7 Protein, Human (HEK293, His)	Q9NQ25-1 (S23-M226)	≥95%
HY-P77202	CRACC/SLAMF7 Protein, Human (HEK293, hFc)	Q9NQ25-1 (S23-M226)	≥95%
HY-P77203	CRACC/SLAMF7 Protein, Human (Biotinylated, HEK293, Fc)	Q9NQ25-1 (S23-M226)	≥95%
HY-P77205	CRACC/SLAMF7 Protein, Human (Biotinylated, HEK293, His)	Q9NQ25-1 (S23-M226)	≥95%
HY-P78517	CRACC/SLAMF7 Protein, Human (HEK293, mFc)	Q9NQ25-1 (S23-M226)	≥95%
HY-P78518	CRACC/SLAMF7 Protein, Human (HEK293, His-Avi)	Q9NQ25-1 (S23-M226)	≥95%

SLAMF7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81432	SLAMF7/CS1 Antibody (YA1177)	IHC-P	Human
HY-P81747	CS1 Antibody (YA1492)	FC, ELISA	Human

Related Diseases

Diseases

Alias

Plasmablastic Lymphoma

Pbl	Immunoblastic Large-Cell Lymphoma

Smoldering Myeloma

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Intellectual Developmental Disorder, Autosomal Dominant 10

MRD10	Mental Retardation, Autosomal Dominant 10
Autosomal Dominant Non-Syndromic Intellectual Disability 10	Autosomal Dominant Intellectual Developmental Disorder 10
Autosomal Dominant Mental Retardation 10	Mental Retardation, Autosomal Dominant, Type 10

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Monoclonal Gammopathy Of Uncertain Significance

Monoclonal Gammopathy Of Undetermined Significance	Mgus
Mgus - [Monoclonal Gammopathy Of Undetermined Significance]	Monoclonal Gammopathy Nos
Iga Gammopathy	Monoclonal Gammoglobulinopathy

Igg4-Related Disease

Multifocal Fibrosclerosis	Igg4-Related Sclerosing Disease
Igg4-Related Systemic Disease	Immunoglobulin G4-Related Sclerosing Disease
Hyper-Igg4 Disease	Igg4-Associated Disease
Igg4-Positive Multiorgan Lymphoproliferative Syndrome	Igg4-Related Autoimmune Disease
Igg4-Related Systemic Sclerosing Disease	Igg4-Syndrome
Multifocal Idiopathic Fibrosclerosis	Systemic Igg4-Related Plasmacytic Syndrome
Systemic Igg4-Related Sclerosing Syndrome	Mediastinal Fibrosis, Familial
Retroperitoneal Fibrosis, Familial	Igg4-Rd

Non-Secretory Myeloma

Blood Protein Disease

Blood Protein Disorders

Blood Protein Disorder

Plasma Cell Leukemia

Plasma Cell Leukaemia	Leukemia, Plasma Cell
Plasmacytic Leukaemia	Plasmacytic Leukemia
Pcl	Plasma Cell Leukaemia, Nos
Leukemic Plasma Cell	Plasma Cell Leukaemia Without Mention Of Remission

Bone Marrow Cancer

Malignant Neoplasm Of Bone Marrow	Bone Marrow Neoplasm
Bone Marrow Tumor	Malignant Bone Marrow Tumor
Myeloproliferative Disorders	Bone Marrow Neoplasms
Myeloproliferative Disease	Chronic Myeloproliferative Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99454	Azintuxizumab vedotin		98.55%	Phase 1

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12981	SLAMF7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99453	Azintuxizumab		≥99.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLAMF7	VGNC	VGNC:34655
Canis familiaris	SLAMF7	VGNC	VGNC:46208
Mus musculus	SLAMF7	MGD	MGI:1922595
Macaca mulatta	SLAMF7	VGNC	VGNC:77547
Rattus norvegicus	SLAMF7	RGD	RGD:1560190
Felis catus	SLAMF7	VGNC	VGNC:107940
Macaca fascicularis	SLAMF7	NCBI	NCBI:102133710
Others	SLAMF7	NCBI

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