2. Gene
  3. RBBP4 - RB binding protein 4, chromatin remodeling factor Gene

RBBP4 - RB binding protein 4, chromatin remodeling factor Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NURF55; RBAP48; lin-53

Gene ID: 5928 | Gene type: protein coding

About RBBP4

Cytogenetic location: 1p35.1 Genomic coordinates (GRCh38): 1:32,651,208-32,686,211 (from NCBI)

This gene has 19 transcripts (splice variants), 262 orthologues and 9 paralogues. Ubiquitous expression in testis (RPKM 27.2), lymph node (RPKM 20.0) and 25 other tissues.

Summary

This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

RBBP4 Products(3)

mRNA Protein Name
NM_001135255.2 NP_001128727.1 histone-binding protein RBBP4 isoform b
NM_001135256.2 NP_001128728.1 histone-binding protein RBBP4 isoform c
NM_005610.3 NP_005601.1 histone-binding protein RBBP4 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
contributes to ATP-dependent activity, acting on DNA IDA
IDA: Inferred from direct assay
14609955 GOA
enables histone binding IDA
IDA: Inferred from direct assay
9651585 GOA
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
17827154 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7503932 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA replication-dependent chromatin assembly IDA
IDA: Inferred from direct assay
8858152 GOA
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
9790534 GOA
involved in nucleosome assembly IDA
IDA: Inferred from direct assay
14718166 GOA
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
14609955 GOA
Cellular Component GO Annotation Evidence Reference Source
part of ATPase complex IDA
IDA: Inferred from direct assay
14609955 GOA
part of CAF-1 complex IDA
IDA: Inferred from direct assay
8858152 GOA
part of CAF-1 complex IPI
IPI: Inferred from physical interaction
9614144 GOA
part of ESC/E(Z) complex IDA
IDA: Inferred from direct assay
20075857 GOA
part of NURF complex IDA
IDA: Inferred from direct assay
20850016 GOA
part of NURF complex IPI
IPI: Inferred from physical interaction
14609955 GOA
part of NuRD complex IDA
IDA: Inferred from direct assay
19644445 GOA
located in chromatin IDA
IDA: Inferred from direct assay
9614144 GOA
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
30045876 GOA
part of histone deacetylase complex IDA
IDA: Inferred from direct assay
9651585 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
22720776 GOA
located in nucleus IDA
IDA: Inferred from direct assay
14609955 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
14718166 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBBP4 Protein Structure

CAF1C_H4-bd

CAF1C_H4-bd: Histone-binding protein RBBP4 or subunit C of CAF1 complex (18 - 88)

WD40

WD40: WD domain, G-beta repeat (171 - 206)

WD40

WD40: WD domain, G-beta repeat (220 - 256)

WD40

WD40: WD domain, G-beta repeat (264 - 302)

WD40

WD40: WD domain, G-beta repeat (310 - 346)

WD40

WD40: WD domain, G-beta repeat (366 - 402)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 425 a.a.
Protein Preferred Names Protein Names

histone-binding protein RBBP4

CAF-1 subunit C

RBBP4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RBBP4 Q09028 q9brl8_human Homo sapiens Q9BRL8
Y2H Prey Pooling
25416956
Intra
RBBP4 Q09028 STIP1 Homo sapiens P31948
Validated Y2H
32814053
Intra
RBBP4 Q09028 STIP1 Homo sapiens P31948
Y2H Array
32814053
Intra
RBBP4 Q09028 STIP1 Homo sapiens P31948
Y2H Pooling
32814053
Intra
RBBP4 Q09028 STAT5B Homo sapiens P51692
Y2H Array
32296183
Intra
RBBP4 Q09028 STAT5B Homo sapiens P51692
Y2H Prey Pooling
32296183
Intra
RBBP4 Q09028 PLP1 Homo sapiens P60201-2
Y2H Pooling
32814053
Intra
RBBP4 Q09028 PLP1 Homo sapiens P60201-2
Validated Y2H
32814053
Intra
RBBP4 Q09028 PLP1 Homo sapiens P60201-2
Y2H Array
32814053
Intra
RBBP4 Q09028 MECOM Homo sapiens Q03112
ITC
30462309
Intra
RBBP4 Q09028 MECOM Homo sapiens Q03112
Pull Down
30462309
Intra
RBBP4 Q09028 CLSTN1 Homo sapiens O94985-2
Validated Y2H
32814053
Intra
RBBP4 Q09028 CLSTN1 Homo sapiens O94985-2
Y2H Array
32814053
Intra
RBBP4 Q09028 CLSTN1 Homo sapiens O94985-2
Y2H Pooling
32814053
Intra
RBBP4 Q09028 LAMP2 Homo sapiens P13473-2
Validated Y2H
32814053
Intra
RBBP4 Q09028 LAMP2 Homo sapiens P13473-2
Y2H Array
32814053
Intra
RBBP4 Q09028 LAMP2 Homo sapiens P13473-2
Y2H Pooling
32814053
Intra
RBBP4 Q09028 HAT1 Homo sapiens O14929
Anti Tag CoIP
33961781
Intra
RBBP4 Q09028 HAT1 Homo sapiens O14929
TAP
24981860
Intra
RBBP4 Q09028 HAT1 Homo sapiens O14929
Validated Y2H
25416956
Intra
RBBP4 Q09028 SH3GLB1 Homo sapiens Q9Y371
Y2H Pooling
32814053
Intra
RBBP4 Q09028 SH3GLB1 Homo sapiens Q9Y371
Validated Y2H
32814053
Intra
RBBP4 Q09028 SH3GLB1 Homo sapiens Q9Y371
Y2H Array
32814053
Intra
RBBP4 Q09028 PRDM16 Homo sapiens Q9HAZ2
Pull Down
30462309
Intra
RBBP4 Q09028 PRDM16 Homo sapiens Q9HAZ2
ITC
30462309
Intra
RBBP4 Q09028 HDAC1 Homo sapiens Q13547
Anti Tag CoIP
35271311
Intra
RBBP4 Q09028 HDAC1 Homo sapiens Q13547
Anti Tag CoIP
9150135
Intra
RBBP4 Q09028 HDAC1 Homo sapiens Q13547
Anti Tag CoIP
33961781
Intra
RBBP4 Q09028 HDAC1 Homo sapiens Q13547
TAP
27705803
Intra
RBBP4 Q09028 TARDBP Homo sapiens Q13148
Validated Y2H
32814053
Intra
RBBP4 Q09028 TARDBP Homo sapiens Q13148
Y2H Array
32814053
Intra
RBBP4 Q09028 TARDBP Homo sapiens Q13148
Y2H Pooling
32814053
Intra
RBBP4 Q09028 ALDH4A1 Homo sapiens P30038
Validated Y2H
32814053
Intra
RBBP4 Q09028 ALDH4A1 Homo sapiens P30038
Y2H Array
32814053
Intra
RBBP4 Q09028 ALDH4A1 Homo sapiens P30038
Y2H Pooling
32814053
Intra
RBBP4 Q09028 ZFPM1 Homo sapiens Q8IX07
SPR
21047798
Intra
RBBP4 Q09028 ZFPM1 Homo sapiens Q8IX07
ITC
21047798
Intra
RBBP4 Q09028 ZFPM1 Homo sapiens Q8IX07
X-Ray Diffraction
21047798
Intra
RBBP4 Q09028 ZFPM1 Homo sapiens Q8IX07
Anti Tag CoIP
33961781
Intra
RBBP4 Q09028 HIP1 Homo sapiens O00291
Validated Y2H
32814053
Intra
RBBP4 Q09028 HIP1 Homo sapiens O00291
Y2H Pooling
32814053
Intra
RBBP4 Q09028 HIP1 Homo sapiens O00291
Y2H Array
32814053
Intra
RBBP4 Q09028 MTA1 Homo sapiens Q13330
Y2H Array
25416956
Intra
RBBP4 Q09028 MTA1 Homo sapiens Q13330
Y2H Prey Pooling
32296183
Intra
RBBP4 Q09028 MTA1 Homo sapiens Q13330
Y2H Array
32296183
Intra
RBBP4 Q09028 MTA1 Homo sapiens Q13330
Y2H Prey Pooling
25416956
Intra
RBBP4 Q09028 MTA1 Homo sapiens Q13330
Anti Tag CoIP
35271311
Intra
RBBP4 Q09028 MTA1 Homo sapiens Q13330
TAP
27705803
Intra
RBBP4 Q09028 MTA1 Homo sapiens Q13330
TAP
24981860
Intra
RBBP4 Q09028 MTA1 Homo sapiens Q13330
Validated Y2H
32296183
Intra
RBBP4 Q09028 MTA1 Homo sapiens Q13330
Anti Tag CoIP
33961781
Intra
RBBP4 Q09028 MTA1 Homo sapiens Q13330
Validated Y2H
25416956
Intra
RBBP4 Q09028 BAG3 Homo sapiens O95817
Validated Y2H
32814053
Intra
RBBP4 Q09028 BAG3 Homo sapiens O95817
Y2H Array
32814053
Intra
RBBP4 Q09028 BAG3 Homo sapiens O95817
Y2H Pooling
32814053
Intra
RBBP4 Q09028 CHRNA7 Homo sapiens P36544
Y2H Pooling
32814053
Intra
RBBP4 Q09028 CHRNA7 Homo sapiens P36544
Validated Y2H
32814053
Intra
RBBP4 Q09028 CHRNA7 Homo sapiens P36544
Y2H Array
32814053
Intra
RBBP4 Q09028 FLNA Homo sapiens P21333-2
Y2H Pooling
32814053
Intra
RBBP4 Q09028 FLNA Homo sapiens P21333-2
Validated Y2H
32814053
Intra
RBBP4 Q09028 FLNA Homo sapiens P21333-2
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RBBP4 Proteins

Cat. No. Product Name Accession Purity
HY-P74601 RBBP4 Protein, Human (sf9, His) Q09028 (M1-S425) ≥95%

Related Diseases

Diseases Alias
Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms
Hutchinson-Gilford Progeria Syndrome

Progeria

HGPS

Hutchinson-Gilford Syndrome

Hutchinson-Gilford Progeria

Hutchinson Gilford Syndrome

Hutchinson Gilford Progeria Syndrome

Hutchinson-Gilford Disease

Progeria Of Childhood

Hutchinson-Gilford-Progeria Syndrome
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma
Weaver Syndrome

Wss

Weaver-Smith Syndrome

WVS

Weaver-Like Syndrome

Weaver-Williams Syndrome

Camptodactyly-Overgrowth-Unusual Facies Syndrome

Camptodactyly - Overgrowth - Unusual Facies

Ezh2 Related Overgrowth

Overgrowth Syndrome With Accelerated Skeletal Maturation, Unusual Facies, And Camptodactyly

Weaver Smith Syndrome

Weaver Like Syndrome

Weaver Williams Syndrome

Camptodactyly-Overgrowth-Unusual Facies

Weaver Syndrome 1

Weaver Syndrome 2

Wvs1

Wvs2
Cockayne Syndrome

Cockayne'S Syndrome

Dwarfism-Retinal Atrophy-Deafness Syndrome

Neill-Dingwall Syndrome

Progeria-Like Syndrome

Progeroid Nanism

Cs
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11716 RBBP4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RBBP4 RGD RGD:1593768
Canis familiaris RBBP4 VGNC VGNC:45391
Felis catus RBBP4 VGNC VGNC:80338
Mus musculus RBBP4 MGD MGI:1194912
Bos taurus RBBP4 VGNC VGNC:33770
Others RBBP4 NCBI