HAT1 - histone acetyltransferase 1 Gene

Homo sapiens

Also known as KAT1

Gene ID: 8520 | Gene type: protein coding

About HAT1

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:171,922,461-171,983,686 (from NCBI)

This gene has 6 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in lymph node (RPKM 13.0), bone marrow (RPKM 11.6) and 25 other tissues.

Summary

The protein encoded by this gene is a type B Histone Acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009]

HAT1 Products(1)

mRNA	Protein	Name
NM_003642.4	NP_003633.2	histone acetyltransferase type B catalytic subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone H4K12 acetyltransferase activity	IDA IDA: Inferred from direct assay	22615379	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19862764	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in nucleosome assembly	IDA IDA: Inferred from direct assay	14718166	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	14718166	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	14718166	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HAT1 Protein Structure

Hat1_N

0
100
200
300
419 a.a.

Protein Preferred Names

Protein Names

histone acetyltransferase type B catalytic subunit

HAT1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HAT1	O14929	STEEP1	Homo sapiens	Q9H5V9	Y2H Prey Pooling	32296183
Intra	HAT1	O14929	STEEP1	Homo sapiens	Q9H5V9	Y2H Array	32296183
Intra	HAT1	O14929	STEEP1	Homo sapiens	Q9H5V9	Validated Y2H	32296183
Intra	HAT1	O14929	REL	Homo sapiens	Q04864-2	Validated Y2H	32296183
Intra	HAT1	O14929	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	HAT1	O14929	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	HAT1	O14929	TEPSIN	Homo sapiens	Q96N21	Validated Y2H	32296183
Intra	HAT1	O14929	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	HAT1	O14929	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	HAT1	O14929	SNAPC1	Homo sapiens	Q16533	Y2H Prey Pooling	32296183
Intra	HAT1	O14929	SNAPC1	Homo sapiens	Q16533	Y2H Array	32296183
Intra	HAT1	O14929	SNAPC1	Homo sapiens	Q16533	Validated Y2H	32296183
Intra	HAT1	O14929	MORN5	Homo sapiens	Q5VZ52	Validated Y2H	32296183
Intra	HAT1	O14929	MORN5	Homo sapiens	Q5VZ52	Y2H Array	32296183
Intra	HAT1	O14929	MORN5	Homo sapiens	Q5VZ52	Y2H Prey Pooling	32296183
Intra	HAT1	O14929	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	HAT1	O14929	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	HAT1	O14929	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	HAT1	O14929	TNFAIP1	Homo sapiens	Q13829	Y2H Prey Pooling	25416956
Intra	HAT1	O14929	TNFAIP1	Homo sapiens	Q13829	Validated Y2H	25416956
Intra	HAT1	O14929	TNFAIP1	Homo sapiens	Q13829	Y2H Array	25416956
Intra	HAT1	O14929	H4C16	Homo sapiens	P62805	Acetylase Assay	22615379
Intra	HAT1	O14929	H4C16	Homo sapiens	P62805	X-Ray Diffraction	22615379
Intra	HAT1	O14929	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	HAT1	O14929	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	HAT1	O14929	TRIB3	Homo sapiens	Q96RU7	Y2H Array	32296183
Intra	HAT1	O14929	TRIB3	Homo sapiens	Q96RU7	Y2H Prey Pooling	32296183
Intra	HAT1	O14929	TRIB3	Homo sapiens	Q96RU7	Validated Y2H	32296183
Intra	HAT1	O14929	TCF4	Homo sapiens	P15884	Y2H Array	25416956
Intra	HAT1	O14929	RBBP4	Homo sapiens	Q09028	Y2H Prey Pooling	25416956
Intra	HAT1	O14929	RBBP4	Homo sapiens	Q09028	Anti Tag CoIP	33961781
Intra	HAT1	O14929	RBBP4	Homo sapiens	Q09028	Y2H Array	25416956
Intra	HAT1	O14929	ZSCAN4	Homo sapiens	Q8NAM6	Validated Y2H	32296183
Intra	HAT1	O14929	ZSCAN4	Homo sapiens	Q8NAM6	Y2H Array	32296183
Intra	HAT1	O14929	ZSCAN4	Homo sapiens	Q8NAM6	Y2H Prey Pooling	32296183
Intra	HAT1	O14929	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
Intra	HAT1	O14929	KANK4	Homo sapiens	Q5T7N3	Y2H Prey Pooling	32296183
Intra	HAT1	O14929	KANK4	Homo sapiens	Q5T7N3	Validated Y2H	32296183
Intra	HAT1	O14929	KANK4	Homo sapiens	Q5T7N3	Y2H Array	32296183
Cross	HAT1	O14929	vpr	Human immunodeficiency virus	P12520	Pull Down	22190034

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cheilitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-154944	JG-2016	Inhibitor	99.00%	Unkown
HY-155655	JC-229	Inhibitor	97.07%	Unkown
HY-114953	BMS-248360	Antagonist	/	Unkown
HY-151195	20S Proteasome-IN-4	Inhibitor	/	Unkown
HY-RS06012	HAT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HAT1	VGNC	VGNC:67538
Mus musculus	HAT1	MGD	MGI:96013
Macaca mulatta	HAT1	VGNC	VGNC:73349
Rattus norvegicus	HAT1	RGD	RGD:1305716
Canis familiaris	HAT1	VGNC	VGNC:50624
Bos taurus	HAT1	VGNC	VGNC:49063

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