2. Gene
  3. HAT1 - histone acetyltransferase 1 Gene

HAT1 - histone acetyltransferase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as KAT1

Gene ID: 8520 | Gene type: protein coding

About HAT1

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:171,922,461-171,983,686 (from NCBI)

This gene has 6 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in lymph node (RPKM 13.0), bone marrow (RPKM 11.6) and 25 other tissues.

Summary

The protein encoded by this gene is a type B Histone Acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009]

HAT1 Products(1)

mRNA Protein Name
NM_003642.4 NP_003633.2 histone acetyltransferase type B catalytic subunit

HAT1 Protein Structure

Hat1_N

Hat1_N: Histone acetyl transferase HAT1 N-terminus (27 - 187)

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  • 419 a.a.
Protein Preferred Names Protein Names

histone acetyltransferase type B catalytic subunit

Related Diseases

Diseases Alias
Cheilitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-154944 JG-2016 Inhibitor 99.00% Unkown
HY-155655 JC-229 Inhibitor 97.07% Unkown
HY-114953 BMS-248360 Antagonist / Unkown
HY-151195 20S Proteasome-IN-4 Inhibitor / Unkown
HY-RS06012 HAT1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus HAT1 VGNC VGNC:67538
Mus musculus HAT1 MGD MGI:96013
Macaca mulatta HAT1 VGNC VGNC:73349
Rattus norvegicus HAT1 RGD RGD:1305716
Canis familiaris HAT1 VGNC VGNC:50624
Bos taurus HAT1 VGNC VGNC:49063