SENP2 - SUMO specific peptidase 2 Gene

Homo sapiens

Also known as AXAM2; SMT3IP2

Gene ID: 59343 | Gene type: protein coding

About SENP2

Cytogenetic location: 3q27.2 Genomic coordinates (GRCh38): 3:185,586,295-185,633,551 (from NCBI)

This gene has 13 transcripts (splice variants), 142 orthologues and 3 paralogues. Broad expression in testis (RPKM 37.1), brain (RPKM 13.4) and 24 other tissues.

Summary

SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to Other proteins. SENP2 is one of a group of Enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]

SENP2 Products(1)

mRNA	Protein	Name
NM_021627.3	NP_067640.2	sentrin-specific protease 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SUMO-specific endopeptidase activity	EXP EXP: Inferred from Experiment	16608850	GOA
enables SUMO-specific endopeptidase activity	IDA IDA: Inferred from direct assay	11896061	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11896061	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	22028379	GOA
involved in positive regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	22028379	GOA
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	22028379	GOA
involved in protein desumoylation	IDA IDA: Inferred from direct assay	20194620	GOA
involved in protein desumoylation	IMP IMP: Inferred from mutant phenotype	21965678	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of nuclear pore	IDA IDA: Inferred from direct assay	12192048	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SENP2 Protein Structure

Peptidase_C48

0
100
200
300
400
500
589 a.a.

Protein Preferred Names

Protein Names

sentrin-specific protease 2

SMT3-specific isopeptidase 2

SENP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SENP2	Q9HC62	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	SENP2	Q9HC62	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	SENP2	Q9HC62	TNFRSF10D	Homo sapiens	Q9UBN6	Validated Y2H	32296183
Intra	SENP2	Q9HC62	TNFRSF10D	Homo sapiens	Q9UBN6	Y2H Array	32296183
Intra	SENP2	Q9HC62	TNFRSF10D	Homo sapiens	Q9UBN6	Y2H Prey Pooling	32296183
Intra	SENP2	Q9HC62	RPRM	Homo sapiens	Q9NS64	Y2H Prey Pooling	32296183
Intra	SENP2	Q9HC62	RPRM	Homo sapiens	Q9NS64	Y2H Array	32296183
Intra	SENP2	Q9HC62	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	SENP2	Q9HC62	HCCS	Homo sapiens	P53701	Y2H Array	32296183
Intra	SENP2	Q9HC62	HCCS	Homo sapiens	P53701	Y2H Prey Pooling	32296183
Intra	SENP2	Q9HC62	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Array	32296183
Intra	SENP2	Q9HC62	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Prey Pooling	32296183
Intra	SENP2	Q9HC62	TMEM239	Homo sapiens	Q8WW34-2	Y2H Array	32296183
Intra	SENP2	Q9HC62	TMEM239	Homo sapiens	Q8WW34-2	Y2H Prey Pooling	32296183
Intra	SENP2	Q9HC62	APOC4	Homo sapiens	P55056	Y2H Array	32296183
Intra	SENP2	Q9HC62	APOC4	Homo sapiens	P55056	Y2H Prey Pooling	32296183
Intra	SENP2	Q9HC62	ACSF2	Homo sapiens	Q96CM8	Y2H Array	32296183
Intra	SENP2	Q9HC62	ACSF2	Homo sapiens	Q96CM8	Y2H Prey Pooling	32296183
Intra	SENP2	Q9HC62	FUNDC1	Homo sapiens	Q8IVP5	Y2H Prey Pooling	25416956
Intra	SENP2	Q9HC62	ARMC12	Homo sapiens	Q5T9G4-2	Y2H Array	32296183
Intra	SENP2	Q9HC62	ARMC12	Homo sapiens	Q5T9G4-2	Y2H Prey Pooling	32296183
Intra	SENP2	Q9HC62	SDR16C5	Homo sapiens	Q8N3Y7	Y2H Prey Pooling	32296183
Intra	SENP2	Q9HC62	SDR16C5	Homo sapiens	Q8N3Y7	Y2H Array	32296183
Intra	SENP2	Q9HC62	SUMO2	Homo sapiens	P61956	Enzymatic Study	17099700
Intra	SENP2	Q9HC62	SUMO2	Homo sapiens	P61956	X-Ray Diffraction	17099700
Intra	SENP2	Q9HC62	SUMO3	Homo sapiens	P55854	Validated Y2H	25416956
Intra	SENP2	Q9HC62	SUMO3	Homo sapiens	P55854	Anti Tag CoIP	25416956
Intra	SENP2	Q9HC62	SUMO3	Homo sapiens	P55854	Enzymatic Study	17099700
Intra	SENP2	Q9HC62	SUMO3	Homo sapiens	P55854	X-Ray Diffraction	17099700
Intra	SENP2	Q9HC62	SYNE4	Homo sapiens	Q8N205	Y2H Array	25416956
Intra	SENP2	Q9HC62	ARL6IP1	Homo sapiens	Q15041	Y2H Prey Pooling	25416956
Intra	SENP2	Q9HC62	AGTRAP	Homo sapiens	Q6RW13	Y2H Array	25416956
Intra	SENP2	Q9HC62	AGTRAP	Homo sapiens	Q6RW13	Y2H Prey Pooling	25416956
Intra	SENP2	Q9HC62	AGTRAP	Homo sapiens	Q6RW13	Validated Y2H	25416956
Intra	SENP2	Q9HC62	KASH5	Homo sapiens	Q8N6L0	Y2H Array	25416956
Intra	SENP2	Q9HC62	KASH5	Homo sapiens	Q8N6L0	Y2H Array	32296183
Intra	SENP2	Q9HC62	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	25416956
Intra	SENP2	Q9HC62	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	32296183
Intra	SENP2	Q9HC62	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	25416956
Intra	SENP2	Q9HC62	SUMO1	Homo sapiens	P63165	Enzymatic Study	17099700
Intra	SENP2	Q9HC62	SUMO1	Homo sapiens	P63165	X-Ray Diffraction	15296745
Intra	SENP2	Q9HC62	IKBKG	Homo sapiens	Q9Y6K9	Anti Tag CoIP	20098747
Intra	SENP2	Q9HC62	IKBKG	Homo sapiens	Q9Y6K9	Pull Down	20098747
Intra	SENP2	Q9HC62	TMEM239	Homo sapiens	Q8WW34	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SENP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71288	SENP2 Protein, Human	Q9HC62-1 (D363-L589)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100708	NSC632839	Inhibitor	98.87%	Unkown
HY-151358	SENP2-IN-1	Inhibitor	/	Unkown
HY-RS12672	SENP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SENP2	VGNC	VGNC:34446
Macaca mulatta	SENP2	VGNC	VGNC:77292
Rattus norvegicus	SENP2	RGD	RGD:708378
Canis familiaris	SENP2	VGNC	VGNC:46006
Mus musculus	SENP2	MGD	MGI:1923076
Felis catus	SENP2	VGNC	VGNC:102839
Others	SENP2	NCBI

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