RBM3 - RNA binding motif protein 3 Gene

Homo sapiens

Also known as RNPL; IS1-RNPL

Gene ID: 5935 | Gene type: protein coding

About RBM3

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:48,574,484-48,581,162 (from NCBI)

This gene has 11 transcripts (splice variants), 168 orthologues and 36 paralogues. Ubiquitous expression in bone marrow (RPKM 49.3), fat (RPKM 41.3) and 25 other tissues.

Summary

This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Multiple alternatively spliced transcript variants that are predicted to encode different isoforms have been characterized although some of these variants fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2008]

RBM3 Products(1)

mRNA	Protein	Name
NM_006743.5	NP_006734.1	RNA-binding protein 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15518812	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM3 Protein Structure

RRM_1

0
100
157 a.a.

Protein Preferred Names

Protein Names

RNA-binding protein 3

RNA binding motif (RNP1, RRM) protein 3

RBM3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RBM3	P98179	CHTOP	Homo sapiens	Q9Y3Y2-3	Y2H Prey Pooling	32296183
Intra	RBM3	P98179	CHTOP	Homo sapiens	Q9Y3Y2-3	Validated Y2H	32296183
Intra	RBM3	P98179	CHTOP	Homo sapiens	Q9Y3Y2-3	Y2H Array	32296183
Intra	RBM3	P98179	RBPMS2	Homo sapiens	Q6ZRY4	Y2H Prey Pooling	32296183
Intra	RBM3	P98179	RBPMS2	Homo sapiens	Q6ZRY4	Validated Y2H	32296183
Intra	RBM3	P98179	RBPMS2	Homo sapiens	Q6ZRY4	Y2H Array	32296183
Intra	RBM3	P98179	RBMY1A1	Homo sapiens	P0DJD3-2	Y2H Prey Pooling	32296183
Intra	RBM3	P98179	RBMY1A1	Homo sapiens	P0DJD3-2	Y2H Array	32296183
Intra	RBM3	P98179	PRR3	Homo sapiens	P79522	Y2H Array	32296183
Intra	RBM3	P98179	PRR3	Homo sapiens	P79522	Y2H Prey Pooling	32296183
Intra	RBM3	P98179	MYPOP	Homo sapiens	Q86VE0	Validated Y2H	32296183
Intra	RBM3	P98179	HNRNPK	Homo sapiens	P61978	Validated Y2H	25416956
Intra	RBM3	P98179	HNRNPK	Homo sapiens	P61978	Y2H Prey Pooling	25416956
Intra	RBM3	P98179	HNRNPK	Homo sapiens	P61978	Anti Tag CoIP	35271311
Intra	RBM3	P98179	SRSF3	Homo sapiens	P84103	Y2H Prey Pooling	32296183
Intra	RBM3	P98179	SRSF3	Homo sapiens	P84103	Y2H Array	32296183
Intra	RBM3	P98179	SNRPA	Homo sapiens	P09012	Y2H Prey Pooling	32296183
Intra	RBM3	P98179	SNRPA	Homo sapiens	P09012	Y2H Array	31515488
Intra	RBM3	P98179	SNRPA	Homo sapiens	P09012	Y2H Array	32296183
Intra	RBM3	P98179	HNRNPK	Homo sapiens	P61978-2	Y2H Array	32296183
Intra	RBM3	P98179	HNRNPK	Homo sapiens	P61978-2	Y2H Prey Pooling	32296183
Intra	RBM3	P98179	KHDRBS3	Homo sapiens	O75525	Y2H Prey Pooling	32296183
Intra	RBM3	P98179	KHDRBS3	Homo sapiens	O75525	Y2H Array	32296183
Intra	RBM3	P98179	KHDRBS2	Homo sapiens	Q5VWX1	Validated Y2H	25416956
Intra	RBM3	P98179	KHDRBS2	Homo sapiens	Q5VWX1	Validated Y2H	32296183
Intra	RBM3	P98179	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Array	25416956
Intra	RBM3	P98179	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Prey Pooling	32296183
Intra	RBM3	P98179	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Array	32296183
Intra	RBM3	P98179	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Array	31515488
Intra	RBM3	P98179	RBMX	Homo sapiens	P38159	Y2H Prey Pooling	32296183
Intra	RBM3	P98179	RBMX	Homo sapiens	P38159	Y2H Array	25416956
Intra	RBM3	P98179	RBMX	Homo sapiens	P38159	Y2H Array	32296183
Intra	RBM3	P98179	RBMX	Homo sapiens	P38159	Validated Y2H	25416956
Intra	RBM3	P98179	RBMY1A1	Homo sapiens	P0DJD3	Validated Y2H	25416956
Intra	RBM3	P98179	RBMY1A1	Homo sapiens	P0DJD3	Y2H Prey Pooling	25416956
Intra	RBM3	P98179	RBMY1A1	Homo sapiens	P0DJD3	Y2H Array	25416956
Intra	RBM3	P98179	RBMY1F	Homo sapiens	Q15415	Y2H Prey Pooling	32296183
Intra	RBM3	P98179	RBMY1F	Homo sapiens	Q15415	Validated Y2H	32296183
Intra	RBM3	P98179	RBMY1F	Homo sapiens	Q15415	Y2H Array	25416956
Intra	RBM3	P98179	RBMY1F	Homo sapiens	Q15415	Y2H Array	32296183
Intra	RBM3	P98179	RBMY1F	Homo sapiens	Q15415	Y2H Prey Pooling	25416956
Intra	RBM3	P98179	PCBP1	Homo sapiens	Q15365	Validated Y2H	32296183
Cross	RBM3	P98179	OPG127	Vaccinia virus	P68318	Pull Down	15518812

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Testicular Malignant Germ Cell Cancer

Malignant Germ Cell Tumor Of Testis

Periampullary Adenocarcinoma

Testicular Germ Cell Cancer

Germ Cell Tumor Of Testis	Testicular Germ Cell Tumor
Testicular Germ Cell Neoplasm	Testicular Malignant Germ Cell Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11747	RBM3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11762	RBMS3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RBM3	VGNC	VGNC:54837
Mus musculus	RBM3	MGD	MGI:1099460
Bos taurus	RBM3	VGNC	VGNC:52813
Rattus norvegicus	RBM3	RGD	RGD:620145
Others	RBM3	NCBI

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