2. Gene
  3. HAPLN2 - hyaluronan and proteoglycan link protein 2 Gene

HAPLN2 - hyaluronan and proteoglycan link protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BRAL1

Gene ID: 60484 | Gene type: protein coding

About HAPLN2

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:156,601,504-156,625,725 (from NCBI)

This gene has 5 transcripts (splice variants), 183 orthologues and 7 paralogues. Biased expression in brain (RPKM 7.0), prostate (RPKM 0.6) and 2 other tissues.

Summary

Predicted to enable hyaluronic acid binding activity. Predicted to be involved in central nervous system development and skeletal system development. Predicted to act upstream of or within establishment of blood-nerve barrier and extracellular matrix assembly. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]

HAPLN2 Products(1)

mRNA Protein Name
NM_021817.3 NP_068589.1 hyaluronan and proteoglycan link protein 2 precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HAPLN2 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (44 - 136)

Xlink

Xlink: Extracellular link domain (147 - 241)

Xlink

Xlink: Extracellular link domain (255 - 337)

  • 0
  • 100
  • 200
  • 300
  • 340 a.a.
Protein Preferred Names Protein Names

hyaluronan and proteoglycan link protein 2

brain link protein-1

HAPLN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra HAPLN2 Q9GZV7 KRT40 Homo sapiens Q6A162
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra HAPLN2 Q9GZV7 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 FNDC3B Homo sapiens Q53EP0-3
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 FNDC3B Homo sapiens Q53EP0-3
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 PPP1R16B Homo sapiens Q96T49
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 PPP1R16B Homo sapiens Q96T49
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 KRT37 Homo sapiens O76014
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 KRT37 Homo sapiens O76014
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 KRTAP19-5 Homo sapiens Q3LI72
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 KRTAP19-5 Homo sapiens Q3LI72
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 KRT85 Homo sapiens P78386
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 KRT85 Homo sapiens P78386
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 KRT33B Homo sapiens Q14525
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 KRT33B Homo sapiens Q14525
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 PSTPIP1 Homo sapiens O43586
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 PSTPIP1 Homo sapiens O43586
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 KRT35 Homo sapiens Q92764
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 KRT35 Homo sapiens Q92764
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 PM20D2 Homo sapiens Q8IYS1
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 PM20D2 Homo sapiens Q8IYS1
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 BANP Homo sapiens Q8N9N5-2
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 BANP Homo sapiens Q8N9N5-2
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 VWC2 Homo sapiens Q2TAL6
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 VWC2 Homo sapiens Q2TAL6
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 ZNF438 Homo sapiens Q7Z4V0
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 ZNF438 Homo sapiens Q7Z4V0
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 CCDC125 Homo sapiens Q86Z20
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 CCDC125 Homo sapiens Q86Z20
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 ASB13 Homo sapiens Q8WXK3-2
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 ASB13 Homo sapiens Q8WXK3-2
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 ZMYND12 Homo sapiens Q9H0C1
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 ZMYND12 Homo sapiens Q9H0C1
Validated Y2H
32296183
Intra HAPLN2 Q9GZV7 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 PNMA1 Homo sapiens Q8ND90
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 PNMA2 Homo sapiens Q9UL42
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 PNMA2 Homo sapiens Q9UL42
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 PNMA2 Homo sapiens Q9UL42
Validated Y2H
32296183
Intra HAPLN2 Q9GZV7 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 PFDN5 Homo sapiens Q99471
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 PFDN5 Homo sapiens Q99471
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 EXOSC8 Homo sapiens Q96B26
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 EXOSC8 Homo sapiens Q96B26
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 OIP5 Homo sapiens O43482
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 CIDEB Homo sapiens Q9UHD4
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 CIDEB Homo sapiens Q9UHD4
Validated Y2H
32296183
Intra HAPLN2 Q9GZV7 CIDEB Homo sapiens Q9UHD4
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 TFCP2 Homo sapiens Q12800
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 TFCP2 Homo sapiens Q12800
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 KRT15 Homo sapiens P19012
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 KRT15 Homo sapiens P19012
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 TRIM23 Homo sapiens P36406
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 FHL3 Homo sapiens Q13643
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 FHL3 Homo sapiens Q13643
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 FHL5 Homo sapiens Q5TD97
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 FHL5 Homo sapiens Q5TD97
Y2H Prey Pooling
32296183
Intra HAPLN2 Q9GZV7 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra HAPLN2 Q9GZV7 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Polycystic Echinococcosis

Human Polycystic Hydatid Disease

Neotropical Echinococcosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06002 HAPLN2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HAPLN2 VGNC VGNC:106378
Mus musculus HAPLN2 MGD MGI:2137300
Rattus norvegicus HAPLN2 RGD RGD:621854
Canis familiaris HAPLN2 VGNC VGNC:53491
Bos taurus HAPLN2 VGNC VGNC:29750
Felis catus HAPLN2 VGNC VGNC:62751