HAPLN2 - hyaluronan and proteoglycan link protein 2 Gene

Homo sapiens

Also known as BRAL1

Gene ID: 60484 | Gene type: protein coding

About HAPLN2

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:156,601,504-156,625,725 (from NCBI)

This gene has 5 transcripts (splice variants), 183 orthologues and 7 paralogues. Biased expression in brain (RPKM 7.0), prostate (RPKM 0.6) and 2 other tissues.

Summary

Predicted to enable hyaluronic acid binding activity. Predicted to be involved in central nervous system development and skeletal system development. Predicted to act upstream of or within establishment of blood-nerve barrier and extracellular matrix assembly. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]

HAPLN2 Products(1)

mRNA	Protein	Name
NM_021817.3	NP_068589.1	hyaluronan and proteoglycan link protein 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HAPLN2 Protein Structure

V-set

Xlink

0
100
200
300
340 a.a.

Protein Preferred Names

Protein Names

hyaluronan and proteoglycan link protein 2

brain link protein-1

HAPLN2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HAPLN2	Q9GZV7	KRT40	Homo sapiens	Q6A162	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
Intra	HAPLN2	Q9GZV7	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	FNDC3B	Homo sapiens	Q53EP0-3	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	FNDC3B	Homo sapiens	Q53EP0-3	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	PPP1R16B	Homo sapiens	Q96T49	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	PPP1R16B	Homo sapiens	Q96T49	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	KRT37	Homo sapiens	O76014	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	KRT37	Homo sapiens	O76014	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	KRT85	Homo sapiens	P78386	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	KRT85	Homo sapiens	P78386	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	KRT33B	Homo sapiens	Q14525	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	KRT33B	Homo sapiens	Q14525	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	PSTPIP1	Homo sapiens	O43586	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	PSTPIP1	Homo sapiens	O43586	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	KRT35	Homo sapiens	Q92764	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	KRT35	Homo sapiens	Q92764	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	PM20D2	Homo sapiens	Q8IYS1	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	PM20D2	Homo sapiens	Q8IYS1	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	BANP	Homo sapiens	Q8N9N5-2	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	BANP	Homo sapiens	Q8N9N5-2	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	VWC2	Homo sapiens	Q2TAL6	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	VWC2	Homo sapiens	Q2TAL6	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	ZNF438	Homo sapiens	Q7Z4V0	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	ZNF438	Homo sapiens	Q7Z4V0	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	CCDC125	Homo sapiens	Q86Z20	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	CCDC125	Homo sapiens	Q86Z20	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	ASB13	Homo sapiens	Q8WXK3-2	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	ASB13	Homo sapiens	Q8WXK3-2	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	ZMYND12	Homo sapiens	Q9H0C1	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	ZMYND12	Homo sapiens	Q9H0C1	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	ZMYND12	Homo sapiens	Q9H0C1	Validated Y2H	32296183
Intra	HAPLN2	Q9GZV7	KRTAP2-4	Homo sapiens	Q9BYR9	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	KRTAP2-4	Homo sapiens	Q9BYR9	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	PNMA1	Homo sapiens	Q8ND90	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	PNMA2	Homo sapiens	Q9UL42	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	PNMA2	Homo sapiens	Q9UL42	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	PNMA2	Homo sapiens	Q9UL42	Validated Y2H	32296183
Intra	HAPLN2	Q9GZV7	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	PFDN5	Homo sapiens	Q99471	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	PFDN5	Homo sapiens	Q99471	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	EXOSC8	Homo sapiens	Q96B26	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	EXOSC8	Homo sapiens	Q96B26	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	OIP5	Homo sapiens	O43482	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	OIP5	Homo sapiens	O43482	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	CIDEB	Homo sapiens	Q9UHD4	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	CIDEB	Homo sapiens	Q9UHD4	Validated Y2H	32296183
Intra	HAPLN2	Q9GZV7	CIDEB	Homo sapiens	Q9UHD4	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	TFCP2	Homo sapiens	Q12800	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	TFCP2	Homo sapiens	Q12800	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	KRT15	Homo sapiens	P19012	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	TRIM23	Homo sapiens	P36406	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	FHL3	Homo sapiens	Q13643	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	FHL3	Homo sapiens	Q13643	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	FHL5	Homo sapiens	Q5TD97	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	FHL5	Homo sapiens	Q5TD97	Y2H Prey Pooling	32296183
Intra	HAPLN2	Q9GZV7	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	HAPLN2	Q9GZV7	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Polycystic Echinococcosis

Human Polycystic Hydatid Disease

Neotropical Echinococcosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06002	HAPLN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HAPLN2	VGNC	VGNC:106378
Mus musculus	HAPLN2	MGD	MGI:2137300
Rattus norvegicus	HAPLN2	RGD	RGD:621854
Canis familiaris	HAPLN2	VGNC	VGNC:53491
Bos taurus	HAPLN2	VGNC	VGNC:29750
Felis catus	HAPLN2	VGNC	VGNC:62751

Name
Email *

	Sorry, but the email address you supplied was invalid.