RPS3 - ribosomal protein S3 Gene

Homo sapiens

Also known as S3

Gene ID: 6188 | Gene type: protein coding

About RPS3

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:75,399,518-75,422,302 (from NCBI)

This gene has 20 transcripts (splice variants), 105 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 566.1), bone marrow (RPKM 278.4) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an Endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

RPS3 Products(4)

mRNA	Protein	Name
NM_001005.5	NP_000996.2	40S ribosomal protein S3 isoform 1
NM_001256802.2	NP_001243731.1	40S ribosomal protein S3 isoform 1
NM_001260506.2	NP_001247435.1	40S ribosomal protein S3 isoform 2
NM_001260507.2	NP_001247436.1	40S ribosomal protein S3 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables DNA N-glycosylase activity	IDA IDA: Inferred from direct assay	18610840	GOA
enables DNA binding	IDA IDA: Inferred from direct assay	18610840	GOA
enables DNA endonuclease activity	IDA IDA: Inferred from direct assay	15707971	GOA
enables DNA-(apurinic or apyrimidinic site) endonuclease activity	IDA IDA: Inferred from direct assay	7775413	GOA
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	20605787	GOA
enables Hsp70 protein binding	IDA IDA: Inferred from direct assay	23911537	GOA
enables Hsp90 protein binding	IDA IDA: Inferred from direct assay	23911537	GOA
enables RNA binding	IDA IDA: Inferred from direct assay	20217897	GOA
contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	18045535	GOA
enables damaged DNA binding	IDA IDA: Inferred from direct assay	14706345	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	15518571	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	20605787	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	18464793	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	23131551	GOA
enables oxidized purine DNA binding	IDA IDA: Inferred from direct assay	14706345	GOA
enables oxidized pyrimidine DNA binding	IDA IDA: Inferred from direct assay	19656744	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15161933	GOA
enables protein kinase A binding	IPI IPI: Inferred from physical interaction	16814409	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	15950189	GOA
enables protein-containing complex binding	IMP IMP: Inferred from mutant phenotype	18045535	GOA
enables small ribosomal subunit rRNA binding	IDA IDA: Inferred from direct assay	18610840	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
enables supercoiled DNA binding	IDA IDA: Inferred from direct assay	15707971	GOA
enables tubulin binding	IDA IDA: Inferred from direct assay	23131551	GOA
enables ubiquitin-like protein conjugating enzyme binding	IPI IPI: Inferred from physical interaction	21968017	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IEP IEP: Inferred from expression pattern	17560175	GOA
involved in DNA repair	IMP IMP: Inferred from mutant phenotype	19059439	GOA
involved in base-excision repair	IDA IDA: Inferred from direct assay	15518571	GOA
involved in cellular response to hydrogen peroxide	IDA IDA: Inferred from direct assay	23911537	GOA
involved in cellular response to reactive oxygen species	IDA IDA: Inferred from direct assay	23911537	GOA
involved in cellular response to tumor necrosis factor	IMP IMP: Inferred from mutant phenotype	18045535	GOA
involved in chromosome segregation	IMP IMP: Inferred from mutant phenotype	23131551	GOA
involved in negative regulation of DNA repair	IMP IMP: Inferred from mutant phenotype	17049931	GOA
involved in negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	19656744	GOA
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	20217897	GOA
involved in positive regulation of DNA repair	IDA IDA: Inferred from direct assay	23911537	GOA
involved in positive regulation of JUN kinase activity	IMP IMP: Inferred from mutant phenotype	22510408	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IGI IGI: Inferred from genetic interaction	18045535	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	18045535	GOA
involved in positive regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18045535	GOA
involved in positive regulation of activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	18045535	GOA
involved in positive regulation of apoptotic signaling pathway	IDA IDA: Inferred from direct assay	14988002	GOA
involved in positive regulation of base-excision repair	IDA IDA: Inferred from direct assay	18973764	GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	IMP IMP: Inferred from mutant phenotype	22510408	GOA
involved in positive regulation of endodeoxyribonuclease activity	IDA IDA: Inferred from direct assay	18973764	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20605787	GOA
involved in positive regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	18045535	GOA
involved in positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	22510408	GOA
involved in positive regulation of microtubule polymerization	IMP IMP: Inferred from mutant phenotype	23131551	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	20041225	GOA
involved in positive regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	18045535	GOA
involved in regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20605787	GOA
involved in response to TNF agonist	IDA IDA: Inferred from direct assay	20041225	GOA
involved in spindle assembly	IMP IMP: Inferred from mutant phenotype	23131551	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of NF-kappaB complex	IDA IDA: Inferred from direct assay	18045535	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	14988002	GOA
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	21871177	GOA
located in cytosol	IDA IDA: Inferred from direct assay	16814409	GOA
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
part of cytosolic small ribosomal subunit	IDA IDA: Inferred from direct assay	8706699	GOA
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	23911537	GOA
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	23911537	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	23131551	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	19460357	GOA
located in nucleus	IDA IDA: Inferred from direct assay	14988002	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	21399639	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	22510408	GOA
is active in postsynaptic density	EXP EXP: Inferred from Experiment	21170055	GOA
is active in postsynaptic density	IDA IDA: Inferred from direct assay	21170055	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	17289661	GOA
located in ribosome	IDA IDA: Inferred from direct assay	19059439	GOA
located in ruffle membrane	IDA IDA: Inferred from direct assay	16814409	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS3 Protein Structure

KH_2

Ribosomal_S3_C

0
100
200
243 a.a.

Protein Preferred Names

Protein Names

40S ribosomal protein S3

IMR-90 ribosomal protein S3

RPS3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RPS3	P23396	LTV1	Homo sapiens	Q96GA3	Y2H Prey Pooling	32296183
Intra	RPS3	P23396	LTV1	Homo sapiens	Q96GA3	Validated Y2H	32296183
Intra	RPS3	P23396	LTV1	Homo sapiens	Q96GA3	Y2H Array	32296183
Intra	RPS3	P23396	LTV1	Homo sapiens	Q96GA3	Anti Tag CoIP	33961781
Intra	RPS3	P23396	NFKB1	Homo sapiens	P19838	Anti Bait CoIP	18045535
Intra	RPS3	P23396	NFKBIA	Homo sapiens	P25963	Anti Tag CoIP	24457201
Intra	RPS3	P23396	NFKBIA	Homo sapiens	P25963	Anti Bait CoIP	18045535
Intra	RPS3	P23396	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	RPS3	P23396	RPS10	Homo sapiens	P46783	Crosslink	30021884
Intra	RPS3	P23396	RPS10	Homo sapiens	P46783	Anti Tag CoIP	33961781
Intra	RPS3	P23396	TP53	Homo sapiens	P04637	Pull Down	19656744
Intra	RPS3	P23396	MDM2	Homo sapiens	Q00987	FRET	19656744
Intra	RPS3	P23396	MDM2	Homo sapiens	Q00987	Pull Down	19656744
Intra	RPS3	P23396	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	19656744
Intra	RPS3	P23396	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	RPS3	P23396	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	RPS3	P23396	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	RPS3	P23396	NEDD8	Homo sapiens	Q15843	Pull Down	18274552
Intra	RPS3	P23396	PPID	Homo sapiens	Q08752	Anti Tag CoIP	21146485
Intra	RPS3	P23396	RELA	Homo sapiens	Q04206	Anti Bait CoIP	18045535
Intra	RPS3	P23396	RELA	Homo sapiens	Q04206	Anti Tag CoIP	24457201
Intra	RPS3	P23396	IKBKB	Homo sapiens	O14920	Anti Tag CoIP	21399639

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RPS3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72294	40S Ribosomal Protein S3/RPS3 Protein, Human (His)	P23396-1 (A2-A243)	≥95%

Related Diseases

Diseases

Alias

Diamond-Blackfan Anemia 8

DBA8	Rps7-Related Diamond-Blackfan Anemia
Anemia, Diamond-Blackfan, Type 8

Craniotubular Dysplasia, Ikegawa Type

CTDI	Craniotubular Dysplasia Ikegawa Type
Doid:0112340

Schopf-Schulz-Passarge Syndrome

SSPS	Eccrine Tumors With Ectodermal Dysplasia
Eccrine Tumors-Ectodermal Dysplasia	Keratosis Palmoplantaris-Cystic Eyelids-Hypodontia-Hypotrichosis Syndrome
Palmoplantar Hyperkeratosis-Cystic Eyelids-Hypodontia-Hypotrichosis Syndrome	Palmoplantar Keratoderma-Cystic Eyelids-Hypodontia-Hypotrichosis Syndrome
Keratosis Palmoplantaris With Cystic Eyelids, Hypodontia, And Hypotrichosis	Keratosis Palmoplantaris With Cystic Eyelids, Hypodontia And Hypotrichosis

Eumycotic Mycetoma

Eumycetoma	Maduromycosis
Mycetoma	Madura Foot
Maduromycosis, Mycotic	Mycotic Mycetoma
Mycetoma Of Foot	Eumycotic Maduromycosis
Mycetoma Due To Fungal Infection

Pontocerebellar Hypoplasia, Type 2e

Pontocerebellar Hypoplasia Type 2	Pontocerebellar Hypoplasia Type 2e
Pch2	PCH2E
Progressive Microcephaly From Birth Extrapyramidal Dyskinesia Chorea Epilepsy	Pontocerebellar Hypoplasia 2e
Pcca2	Progressive Cerebello-Cerebral Atrophy Type 2
Doid:0112328	Hypoplasia, Pontocerebellar, Type 2e
Pontocerebellar Hypoplasia, Type 2d	Pontocerebellar Hypoplasia Type 2a

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12242	RPS3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12243	RPS3A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RPS3	VGNC	VGNC:104326
Bos taurus	RPS3	VGNC	VGNC:34138
Rattus norvegicus	RPS3	RGD	RGD:619888
Mus musculus	RPS3	MGD	MGI:1350917
Canis familiaris	RPS3	VGNC	VGNC:45736
Macaca mulatta	RPS3	VGNC	VGNC:101393
Others	RPS3	NCBI

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