BID - BH3 interacting domain death agonist Gene

Homo sapiens

Also known as FP497

Gene ID: 637 | Gene type: protein coding

About BID

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:17,734,138-17,774,665 (from NCBI)

This gene has 11 transcripts (splice variants) and 90 orthologues. Ubiquitous expression in bone marrow (RPKM 13.8), brain (RPKM 9.4) and 24 other tissues.

Summary

This gene encodes a death agonist that heterodimerizes with either agonist Bax or antagonist BCL2, and thus regulate Apoptosis. The encoded protein is a member of the Bcl-2 Family of cell death regulators. It is a mediator of mitochondrial damage induced by Caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Aug 2020]

BID Products(7)

mRNA	Protein	Name
NM_001196.4	NP_001187.1	BH3-interacting domain death agonist isoform 2
NM_001244567.1	NP_001231496.1	BH3-interacting domain death agonist isoform 2
NM_001244569.1	NP_001231498.1	BH3-interacting domain death agonist isoform 3
NM_001244570.1	NP_001231499.1	BH3-interacting domain death agonist isoform 3
NM_001244572.1	NP_001231501.1	BH3-interacting domain death agonist isoform 3
NM_197966.3	NP_932070.1	BH3-interacting domain death agonist isoform 1
NM_197967.2	NP_932071.1	BH3-interacting domain death agonist isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9463381	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in establishment of protein localization to membrane	IDA IDA: Inferred from direct assay	21041309	GOA
involved in hepatocyte apoptotic process	IDA IDA: Inferred from direct assay	32029622	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17289999	GOA
involved in positive regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21459798	GOA
involved in positive regulation of intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21262771	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	19074440	GOA
involved in positive regulation of release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	32029622	GOA
involved in positive regulation of release of cytochrome c from mitochondria	IGI IGI: Inferred from genetic interaction	21041309	GOA
involved in positive regulation of release of cytochrome c from mitochondria	IMP IMP: Inferred from mutant phenotype	17289999	GOA
involved in release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	17052454	GOA
involved in supramolecular fiber organization	IDA IDA: Inferred from direct assay	33106313	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	29531808	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BID Protein Structure

BID

0
100
195 a.a.

Protein Preferred Names

Protein Names

BH3-interacting domain death agonist

Human BID coding sequence

BID Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BID	P55957	BCL2L1	Homo sapiens	Q07817-1	SPR	17289999
Intra	BID	P55957	BCL2L1	Homo sapiens	Q07817-1	FPS	19074440
Intra	BID	P55957	BCL2L1	Homo sapiens	Q07817-1	SPR	15694340
Intra	BID	P55957	BCL2L1	Homo sapiens	Q07817-1	Anti Tag CoIP	17289999
Intra	BID	P55957	BAX	Homo sapiens	Q07812	Anti Tag CoIP	17289999
Intra	BID	P55957	BAX	Homo sapiens	Q07812	X-Ray Diffraction	23374347
Intra	BID	P55957	BAX	Homo sapiens	Q07812	SPR	17289999
Intra	BID	P55957	BAK1	Homo sapiens	Q16611	NMR	23604079
Intra	BID	P55957	BAK1	Homo sapiens	Q16611	Anti Bait CoIP	23782464
Intra	BID	P55957	BAK1	Homo sapiens	Q16611	Solution Sedimentation	23604079
Intra	BID	P55957	CAV1	Homo sapiens	Q03135	Anti Bait CoIP	21382479
Intra	BID	P55957	CAV1	Homo sapiens	Q03135	Confocal	21382479
Intra	BID	P55957	BCL2L2	Homo sapiens	Q92843	SPR	17289999
Intra	BID	P55957	BCL2L2	Homo sapiens	Q92843	Anti Tag CoIP	17289999
Intra	BID	P55957	BCL2L2	Homo sapiens	Q92843	SPR	15694340
Cross	BID	P55957	Bcl2a1	Mus musculus	Q07440	SPR	17289999
Cross	BID	P55957	OPG035	vaccinia virus	P17361	Anti Bait CoIP	17485524
Cross	BID	P55957	OPG035	vaccinia virus	P17361	FPS	17123957
Intra	BID	P55957	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	BID	P55957	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	BID	P55957	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	BID	P55957	BCL2	Homo sapiens	P10415	CoIP	12624108
Intra	BID	P55957	BCL2	Homo sapiens	P10415	Anti Bait CoIP	9463381
Intra	BID	P55957	BCL2	Homo sapiens	P10415	Anti Tag CoIP	17289999
Intra	BID	P55957	BCL2	Homo sapiens	P10415	FPS	16697956
Intra	BID	P55957	BCL2	Homo sapiens	P10415	SPR	17289999
Intra	BID	P55957	BCL2L1	Homo sapiens	Q07817	PLA	25241761

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BID Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7662	BID Protein, Human	P55957 (M1-D195)	≥95%

Related Diseases

Diseases

Alias

Colon Adenocarcinoma

Adenocarcinoma Of Colon	Adenocarcinoma Of The Colon
Colonic Adenocarcinoma

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Cervical Cancer

Cervical Cancer, Somatic	Neoplasm Of Uterine Cervix
Cervix Cancer	Uterine Cervical Neoplasm
Cervical Neoplasm	Cervix Uteri Cancer
Tumor Of The Cervix Uteri	CERCA
Uterine Cervical Cancer	Neoplasms Cervical
Uterine Cervical Neoplasms	Cervical Cancers
Cancer, Cervical, Somatic	Malignant Tumor Of Cervix
Cervix Carcinoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Clubfoot

Congenital Talipes Equinovarus	Congenital Clubfoot
Congenital Equinovarus	Equinovarus Deformity Of Foot
Club Foot

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0493	Niflumic acid	Inhibitor	99.88%	Unkown

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10510	BI-D1870		99.72%	Unkown
HY-103661	BI-6C9	Inhibitor	98.47%	Unkown
HY-18601	(±)-BI-D	Inhibitor	98.06%	Unkown
HY-123244	YC137		/	Unkown
HY-162642	Bfl-1-IN-3	Inhibitor	/	Unkown
HY-P10614	Bid BH3 peptide		/	Unkown
HY-P5325	Bid BH3 (80-99)		/	Unkown
HY-P5325F	Bid BH3 (80-99), FAM labeled		/	Unkown
HY-P5327	r8 Bid BH3		/	Unkown
HY-RS01502	BID Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-121200	Azadirone		/	Unkown
HY-167881	MLS-0053105	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BID	VGNC	VGNC:26496
Rattus norvegicus	BID	RGD	RGD:620160
Felis catus	BID	VGNC	VGNC:60115
Macaca mulatta	BID	VGNC	VGNC:70250
Canis familiaris	BID	VGNC	VGNC:38456
Mus musculus	BID	MGD	MGI:108093
Others	BID	NCBI

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