SUMO3 - small ubiquitin like modifier 3 Gene

Homo sapiens

Also known as SMT3A; Smt3B; SMT3H1; SUMO-3

Gene ID: 6612 | Gene type: protein coding

About SUMO3

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:44,805,617-44,818,062 (from NCBI)

This gene has 6 transcripts (splice variants), 221 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 42.6), bone marrow (RPKM 40.3) and 25 other tissues.

Summary

This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014]

SUMO3 Products(2)

mRNA	Protein	Name
NM_001286416.2	NP_001273345.1	small ubiquitin-related modifier 3 isoform 2
NM_006936.3	NP_008867.2	small ubiquitin-related modifier 3 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17000644	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA binding	IDA IDA: Inferred from direct assay	16626738	GOA
involved in protein sumoylation	IDA IDA: Inferred from direct assay	11889051	GOA
involved in regulation of protein localization to nucleus	IDA IDA: Inferred from direct assay	19050011	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in PML body	IDA IDA: Inferred from direct assay	19050011	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21965678	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUMO3 Protein Structure

Rad60-SLD

0
103 a.a.

Protein Preferred Names

Protein Names

small ubiquitin-related modifier 3

SMT3 suppressor of mif two 3 homolog 1

Recombinant SUMO3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71346	SUMO3 Protein, Human (HEK293, His)	P55854 (S2-G92)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14027	SUMO3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SUMO3	MGD	MGI:1336201
Rattus norvegicus	SUMO3	RGD	RGD:1561022
Bos taurus	SUMO3	VGNC	VGNC:56237

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